Browsing by Author "Pimentel-Quiroz, Victor R."

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    Performance of the 2019 American College of Rheumatology/European League Against Rheumatism Classification Criteria for IgG4-Related Disease in a Latin American Cohort
    (2024) Martin-Nares, Eduardo; Hernandez-Molina, Gabriela; Baenas, Diego Federico; Delgado de la Mora, Jesus; Caeiro, Francisco; Wurmann Kiblisky, Pamela; Pimentel-Quiroz, Victor R.; Ascuna Valdivia, Valery; Faz-Munoz, David; Saad, Emanuel Jose; Cairoli, Ernesto; Elgueta Pinochet, Sergio; Madariaga Charaja, Hugo; Montante-Montes de Oca, Daniel; Gallo, Jesica Romina; Ugarte-Gil, Manuel F.; Neira, Oscar; Burgos, Paula I.; Paira, Sergio
    Background/ObjectiveThe 2019 American College of Rheumatology/European League Against Rheumatism Classification Criteria (2019 AECC) for IgG4-related disease (IgG4-RD) is considered a significant advancement in the study of this condition. Most studies evaluating their performance have focused on White and Asian patients, leaving a knowledge gap regarding Latin American populations. Therefore, this study aimed to assess the performance of the 2019 AECC for IgG4-RD in a cohort of Latin American patients.MethodsA multicenter medical records review study was conducted, involving centers from Argentina, Chile, Mexico, Peru, and Uruguay. Data on IgG4-RD patients and mimicker conditions were collected through a standardized online form. The criterion standard for diagnosing IgG4-RD was based on the fulfillment of the Comprehensive Diagnostic Criteria for IgG4-RD and/or the Consensus Statement on Pathology. The 2019 AECC was retrospectively applied.ResultsWe included 300 patients, with 180 (60%) having IgG4-RD and 120 (40%) having mimicker conditions. The 2019 AECC had a sensitivity of 66.7% and a specificity of 100%. Sensitivity increased to 73.3% when disease-specific autoantibody items were removed, without affecting specificity. The true-positive cases had more involved organs, a higher availability of biopsy results, and were more likely to belong to the Mikulicz/systemic and proliferative phenotypes.ConclusionsThe use of the 2019 AECC for IgG4-RD in a Latin American population confirms its high specificity in excluding those without the disease. The presence of concomitant autoimmune diseases and clinically nonsignificant disease-specific autoantibodies excludes a significant number of patients from fulfilling the criteria.