Browsing by Author "Poblete, Fernando"

Now showing 1 - 5 of 5
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    Adaptation and validation of a questionnaire to measure stigma toward mental illness among health professionals working in primary care in Chile
    (2019) Sapag Muñoz de la Peña, Jaime; Velasco Grandón, Paola Renée; Parra, Claudia; Anríquez, Samanta; Villarroel, Luis; Alvarado, Rubén; Poblete, Fernando; Jofré, Ana; Aracena Álvarez, Marcela; Bravo, Paulina; Mascayano, Franco; Álvarez, Cinthia; Chacón, Sergio; De Arcas, Michelle; Ulloa, Viviana; Barrios, Daniela; Díaz, Andrés; Sena, Brena
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    Cross-cultural adaptation of four instruments to measure stigma towards people with mental illness and substance use problems among primary care professionals in Chile
    (2022) Parra Videla, Claudia; Sapag Muñoz de la Peña, Jaime; Klabunde, Rachel; Velasco, Paola R.; Anríquez, Samanta; Aracena Álvarez, Marcela; Mascayano, Franco; Bravo, Paulina; Sena, Brena F.; Jofré Escalona, Ana; Bobbili, Sireesha J.; Corrigan, Patrick W.; Bustamante, Inés; Poblete, Fernando; Alvarado, Rubén
    Stigma toward people with mental illness and substance use problems is a significant global concern, and prevents people with these conditions from accessing treatment, particularly in primary health care (PHC) settings. Stigma is a cultural phenomenon that is influenced by particular contexts and can differ by country and region. The majority of stigma research focuses on Europe or North America leading to a lack of culturally relevant stigma research instruments for the Latin American context. The present study describes and discusses the methodology for cross-culturally adapting four stigma measurement scales to the Chilean context. The cross-cultural adaptation process included nine phases: (1) preparation; (2) independent translations; (3) synthesis 1 with expert committee; (4) focus groups and interviews with researchers, PHC professionals, and PHC users; (5) synthesis 2 with expert committee; (6) independent back translations; (7) synthesis 3 with expert committee; (8) pilot with PHC professionals; and (9) final revisions. The adaptation process included an array of diverse voices from the PHC context, and met three adaptation objectives defined prior to beginning the process (Understandability, Relevance, and Acceptability and Answer Options). The resulting, culturally adapted questionnaire is being validated and implemented within PHC settings across Chile to provide in-depth insight into stigma among PHC professionals in the country. The authors hope it will be useful for future research on mental illness and substance use stigma in similar settings across Latin America.
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    Increased morbidity and use of Primary Care medical services in patients with major depressive disorder and their families: A retrospective cohort study
    (EDICIONES DOYMA S A, 2012) Garcia Huidobro, Diego; Leon, Tomas; Vidal, Guillermo; Poblete, Fernando; Rojas, Patricio
    Objective: To study the impact of non-psychiatric medical visits by patients with Major Depressive Disorder (MDD) and their family members, compared to healthy people and their relatives in Primary Care.
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    Unravelling geological controls on groundwater flow and surface water-groundwater interaction in mountain systems: A multi-disciplinary approach
    (ELSEVIER, 2023) Marti, Etienne Bernard Christian; Leray, Sarah Tiphaine Lucile; Villela, Daniela; Maringue Canales, José Ignacio; Yañez Morroni, Gonzalo José; Salazar, Esteban; Poblete, Fernando; Jiménez, Jose; Reyes, Gabriela; Poblete Farias, Guillermo Hernán; Huaman Sevilla, Zeidy Lisseth; Figueroa González, Ronny Javier; Araya Vargas, Jaime Andrés; Sanhueza, Jorge; Muñoz, Marjorie; Charrier, Reynaldo; Fernández, Gabriel
    Mountain water resources are considered to be the world's water towers. Still, despite their importance for downstream societies and ecosystems and their vulnerability to climate change, they remain poorly understood - It is the case in particular of mountain groundwater systems. Their complexity makes them difficult to conceptualize, while their remoteness makes them difficult to study, both observationally and instrumentally. Understanding mountain hydrogeological systems is mostly limited by the lack of characterization of the subsurface geologic framework and by the limited understanding of the role of geological structures on groundwater flow and on surface water-groundwater interaction. Removing methodological barriers is therefore a necessary step for improving the understanding of mountain hydrogeological systems. To tackle this problem, we develop a comprehensive multi-disciplinary approach to gain insights into the hydrogeological role of geological structures in ungauged mountain catchments. The methodology consists of several complementary methods: (1) geological mapping at multiple scales; (2) a geophysical study including on ground Electrical Resistivity Tomography (ERT) and, gravimetry transects, and a UAV-based magnetic survey; (3) hydraulic data, including a 9 km long transect of streamflow measurements in the recession period, the longterm Normalized Difference Vegetation Index (NDVI), and varied hydric markers (e.g., a thermal spring and a puddle). The methodology is tested in the Parque Nacional del Rio Clarillo, an ungauged catchment in the Andes Mountains (& AP;130 km2) that is illustrative of the complexity of mountain hydrosystems featuring fault zones, weathered zones, intrusive rocks, and volcano-sedimentary successions.An increase of approximately 50% in the streamflow is observed over a short distance of 1 km. Such a localized and significant increase in the baseflow is not related to any superficial supply and can only be explained by groundwater exfiltration. Based on the multiscale geological mapping and geophysical survey, a regional N-S fault and a secondary set of E-W local faults are identified in the vicinity of the resurgence area, which conjointly are likely to export groundwater from a neighbouring subcatchment up to the resurgence area. Downstream of the resurgence area, no significant change in the baseflow is observed, corresponding to the presence of an impermeable granitic pluton identified by the geological and geophysical mapping. Finally, a fractured zone in the Andean foothills is identified in the volcanic unit, which coincides with a perennial thermal spring, indicating upwelling flow and hydrogeological connectivity between the mountain block and the alluvial basin.The results strongly support the ability of the proposed methodology to identify geological structures that substantially impact the evolution of the baseflow through the catchment. The complementary multi-disciplinary methods are used innovatively to infer the link between geological and hydrogeological structures. The methodology does not aim to fully characterize the geological framework of the catchment but pragmatically focuses on hydrogeologically pertinent structures that may impact baseflow and consequently catchment management.
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    Val/Leu(247) and Trp/Ser(316) polymorphisms in beta(2) glycoprotein I and their association with thrombosis in unselected Chilean patients
    (SPRINGER, 2007) Palomo, Ivan; Pereira, Jaime; Alarcon, Marcelo; Vasquez, Marcela; Pinochet, Carmen; Poblete, Fernando; Mendez, Evelyn; Sandoval, Jeannette; Vidal, Rolando; Pierangeli, Silvia
    It is known that polymorphisms of beta (2)-glycoprotein I (beta (2)GPI) in exon 7 affect interaction between the phospholipid binding site and the antibodies, and that other polymorphisms in exon 8 increase the generation of antibodies. In this study, we analyzed genetic polymorphisms of beta (2)GPI in unselected Chilean patients to determine the prevalence of beta (2)GPI polymorphisms in the phospholipid domain in patients with venous and arterial thrombosis and the clinical correlation with thromboembolic complications. This study comprised 149 patients with venous and arterial thrombosis (62 with venous thrombosis and 87 with arterial thrombosis) and 160 healthy controls with no previous history of thrombosis. Polymorphisms of exons 7 and 8 of beta (2)GPI, which encode for its fifth domain, were determined by PCR-RFLP. The presence of aPL or anti-beta (2)GPI in the patients was detected by ELISA. Anti-beta (2)GPI were present in 8/149 patients (5.4%); of these, five had aCL antibodies of low titer. The allele containing Val/Leu(247) and Trp/Ser(316) was significantly more frequent in patients with thrombosis than in the control group (OR=3.1, CI 1.6-6.0, p=0.0003; OR=2.9, CI 1.1-8.6, p=0.027, respectively). These polymorphisms did not correlate with aPL or anti-beta (2)GPI but significant differences were observed with venous thrombosis (p=< 0.0001) and arterial thrombosis (p=0.026). In conclusion, the beta (2)GPI polymorphisms Val/Leu(247) and Trp/Ser(316) are not related to the presence of anti-beta (2)GPI antibodies in unselected Chilean patients with venous and arterial thrombosis, but they are significantly associated with venous and arterial thrombosis.