Browsing by Author "Pons-Estel, Guillermo J."

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    A longitudinal multiethnic study of biomarkers in systemic lupus erythematosus: Launching the GLADEL 2.0 Study Group
    (2021) Gomez-Puerta, Jose A.; Pons-Estel, Guillermo J.; Quintana, Rosana; Nieto, Romina; Serrano Morales, Rosa M.; Harvey, Guillermina B.; Wojdyla, Daniel; Scolnik, Marina; Funes Soaje, Carmen; Alba Moreyra, Paula; Novatti, Elisa; Arizpe, Fernando; Berbotto, Guillermo A.; Gonzalez Lucero, Luciana; Porta, Sabrina; Perez, Nicolas; Rodriguez, Anabella M.; Appenzeller, Simone; de Oliveira e Silva Montadon, Ana Carolina; Monticielo, Odirlei Andre; Cavalcanti, Fernando S.; Ribeiro, Francinne Machado; Borba, Eduardo F.; dos Reis-Neto, Edgard Torres; Neira, Oscar; Miguel Chahuan, Jose; Mimica, Milena; Aroca Martinez, Gustavo; Tobon, Gabriel J.; Vasquez, Gloria; Quintana-Lopez, Gerardo; Moreno Alvarez, Mario J.; Angel Saavedra, Miguel; Perez Cristobal, Mario; Fragoso-Loyo, Hilda; Amezcua-Guerra, Luis M.; Gonzalez-Bello, Yelitza C.; Abud-Mendoza, Carlos; Esquivel-Valerio, Jorge A.; Duarte, Margarita; Acosta Colman, Isabel; Mora-Trujillo, Claudia; Reategui-Sokolova, Cristina; Calvo Quiroz, Armando A.; Munoz-Louis, Roberto; Cairoli, Ernesto; Rosas, Iliana; Rebella, Martin; Cardiel, Mario H.; Garcia de la Torre, Ignacio; Catoggio, Luis J.; Alarcon, Graciela S.; Pons-Estel, Bernardo A.
    Introduction: After more than 20 years of sustained work, the Latin American Group for the Study of Lupus (GLADEL) has made a significant number of contributions to the field of lupus, not only in the differential role that race/ethnicity plays in its course and outcome but also in several other studies including the beneficial effects of using antimalarials in lupus patients and the development of consensus guidelines for the treatment of lupus in our region. Methods: A new generation of "Lupus Investigators" in more than 40 centers throughout Latin America has been constituted in order to continue the legacy of the investigators of the original cohort and to launch a novel study of serum and urinary biomarkers in patients with systemic lupus erythematosus. Results: So far, we have recruited 807 patients and 631 controls from 42 Latin-American centers including 339 patients with SLE without renal involvement, 202 patients with SLE with prevalent but inactive renal disease, 176 patients with prevalent and active renal disease and 90 patients with incident lupus nephritis. Conclusions: The different methodological aspects of the GLADEL 2.0 cohort are discussed in this manuscript, including the challenges and difficulties of conducting such an ambitious project.
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    Impact of COVID-19 pandemic on patients with rheumatic diseases in Latin America
    (2022) Fernandez-Avila, Daniel G.; Barahona-Correa, Julian; Romero-Alvernia, Diana; Kowalski, Sergio; Sapag, Ana; Cachafeiro-Vilar, Antonio; Melendez, Belia; Pastelin, Carlos; Palleiro, Daniel; Arrieta, Dina; Reyes, Gil; Pons-Estel, Guillermo J.; Then-Baez, Jossiell; Ugarte-Gil, Manuel F.; Cardiel, Mario H.; Colman, Nelly; Chavez, Nilmo; Burgos, Paula, I; Montufar, Ruben; Sandino, Sayonara; Fuentes-Silva, Yurilis J.; Soriano, Enrique R.
    The objective of our study was to describe knowledge, attitudes and practices of Latin-American rheumatology patients regarding management and follow-up of their disease during COVID-19 pandemic. A cross-sectional observational study was conducted using a digital anonymous survey. Rheumatic patients >= 18 years from non-English-speaking PANLAR countries were included. Our survey included 3502 rheumatic patients living in more than 19 Latin-American countries. Median age of patients was 45.8(36-55) years and the majority (88.9%) was female. Most frequently self-reported disease was rheumatoid arthritis (48.4%). At least one anti-rheumatic treatment was suspended by 23.4% of patients. Fear of contracting SARS-Cov2 (27.7%) and economic issues (25%) were the most common reasons for drug discontinuation. Self-rated disease activity increased from 30 (7-50) to 45 (10-70) points during the pandemic. Communication with their rheumatologist during the pandemic was required by 55.6% of patients, mainly by telephone calls (50.2%) and social network messages (47.8%). An adequate knowledge about COVID-19 was observed in 43% of patients. Patients with rheumatic diseases in Latin America were negatively affected by the COVID-19 pandemic. An increase in self-rated disease activity, a reduction in medication adherence, and hurdles for medical follow-up were reported. Teleconsultation was perceived as a valid alternative to in-person visits during the pandemic.
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    Impact of COVID-19 Pandemic on Rheumatology Practice in Latin America
    (2021) Fernandez-Avila, Daniel G.; Barahona-Correa, Julian; Romero-Alvernia, Diana; Kowalski, Sergio; Sapag, Ana; Cachafeiro-Vilar, Antonio; Melendez, Belia; Santiago-Pastelin, Carlos; Palleiro, Daniel; Arrieta, Dina; Reyes, Gil; Pons-Estel, Guillermo J.; Then-Baez, Jossiell; Ugarte-Gil, Manuel F.; Cardiel, Mario H.; Colman, Nelly; Chavez, Nilmo; Burgos, Paula, I; Montufar, Ruben; Sandino, Sayonara; Fuentes-Silva, Yurilis J.; Soriano, Enrique R.
    Objective. To describe the effect of the coronavirus disease 2019 (COVID-19) pandemic on Latin American rheumatologists from a professional, economic, and occupational point of view. Methods. We conducted an observational cross-sectional study using an online survey sent to rheuma-tologists of each non-English-speaking country member of the Pan American League of Rheumatology Associations (PANLAR). A specific questionnaire was developed. Results. Our survey included 1097 rheumatologists from 19 Latin American countries. Median (IQR) age of respondents was 48 (40-59) years and 618 (56.3%) were female. Duration of practice since graduation as a rheumatologist was 17 years, and 585 (53.3%) were aged < 50 years. Most rheumatologists worked in private practice (81.8%) and almost half worked in institutional outpatient centers (55%) and inpatient care (49.9%). The median number of weekly hours (IQR) of face-to-face practice before the pandemic was 27 (15-40) hours, but was reduced to 10 (5-20) hours during the pandemic. Telehealth was used by 866 (78.9%) respondents during the pandemic. Most common methods of communication were video calls (555; 50.6%), telephone calls (499; 45.5%), and WhatsApp voice calls (423; 38.6%). A reduction in monthly wages was reported by 946 (86.2%) respondents. Consultation fees also were reduced and 88 (8%) rheumatologists stated they had lost their jobs. A reduction in patient adherence to medication was reported by nearly 50% of respondents. Eighty-one (7.4%) rheumatologists received a COVID-19 diagnosis and 7 (8.6%) of them were hospitalized. Conclusion. The COVID-19 pandemic has reshaped rheumatology practice in Latin America and has had a profound effect on rheumatologists' behaviors and clinical practice.
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    Remission and Low Disease Activity Status (LDAS) protect lupus patients from damage occurrence: data from a multiethnic, multinational Latin American Lupus Cohort (GLADEL)
    (2017) Ugarte Gil, Manuel Francisco; Wojdyla, Daniel; Pons-Estel, Guillermo J.; Catoggio, Luis J.; Drenkard, Cristina; Sarano, Judith; Berbotto, Guillermo A.; Borba, Eduardo F.; Sato Inoue, Emilia; Massardo Vega, Loreto