Browsing by Author "Quezada Sanhueza, Nicolás"

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    Bariatric surgery in 1119 patients with preoperative body mass index < 35 (kg/m(2)) : results at 1 year
    (2015) Maiz, Cristobal; Alvarado, Juan; Quezada Sanhueza, Nicolás; Salinas, Jose; Funke, Ricardo
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    Dexmedetomidine metabolic clearance is not affected by fat mass in obese patients
    (2018) Rolle, A.; Paredes, S.; Cortínez Fernández, Luis Ignacio; Anderson, B. J.; Quezada Sanhueza, Nicolás; Solari, S.; Allende, Fidel; Torres, J.; Cabrera, D.; Contreras, V.; Carmona, J.; Ramirez, C.; Oliveros, A. M.; Ibacache Figueroa, Mauricio Enrique
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    Distinct patterns in the gut microbiota after surgical or medical therapy in obese patients
    (2017) Medina, D. A.; Pedreros, J. P.; Turiel, D.; Quezada Sanhueza, Nicolás; Pimentel Muller, Fernando; Escalona, Alex; Garrido Cortés, Daniel
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    Effect of cholecystectomy on hepatic fat accumulation and insulin resistance in non-obese Hispanic patients : a pilot study
    (2017) Cortés Mora, Víctor Antonio; Quezada Sanhueza, Nicolás; Uribe Arancibia, Sergio A.; Arrese Jiménez, Marco; Nervi, Flavio
    Abstract Background Nonalcoholic fatty liver disease (NAFLD) is highly prevalent worldwide. Experimental studies have shown that cholecystectomy (XGB) increases hepatic fat content in mice and appears associated to NAFLD in large retrospective population-based studies. The aim of this study was to prospectively assess the effects of XGB on hepatic fat content (HFC) and insulin resistance (IR) in non-obese, middle aged Hispanic subjects. Methods Twenty-six gallstone patients undergoing elective XGB and 16 control subjects with normal livers and gallbladders at ultrasonography were prospectively followed 24 months for changes in HFC and IR. Clinical, biochemical determinations and hepatic imaging were performed at baseline and 24 months after surgery. MRI technique quantified HFC in four hepatic segments. IR was assessed by the Homeostasis Model Assessment (HOMA-IR) index. Results Initial body mass index (BMI) was 25.6 ± 0.4 and 24.3 ± 1.0 in the control and XGB groups of subjects, respectively. Serum insulin level increased from 8.1 ± 0.7 to 10.0 ± 1.9 (μU/ml) 24 months after surgery in XGB patients (p < 0.05); no significant changes were detected in control individuals. Median HOMA-IR index increased from 1.31 (interquartile range, 1.01-1.68) to 2.20 (interquartile range, 1.57 - 2.60) 24 months after XGB, (p < 0.003). Median HOMA-IR index of control subjects remained unchanged at the end of the study. Serum apoB concentration increased from 61.5 ± 3.4 to 79.0 ± 7.8 (μg/ml) in XGB patients (p < 0.03). Serum apoB levels remained within normal ranges in both periods of the study in control subjects. HFC significantly increased in 2 of the 4 segments 24 months after XGB: right posterior hepatic lobe (from 5.3 ± 0.2% to 6.0 ± 0.2%, p > 0.04) and right anterior hepatic lobe (from 5.8 ± 0.2% to 6.6 ± 0.3%, p < 0.02). The average HFC of the four hepatic segments studied slightly increased from 5.4 ± 0.2 to 5.8 ± 0.3 2 years after XGB (p < 0.03). No significant changes were found in HFC in the control subjects at the end of the study. Conclusions Elective XGB increases HFC, HOMA-IR index and serum apoB concentration. These results support the notion that XGB is a risk factor non-alcoholic fatty liver disease and other IR – associated disease conditions.
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    Effect of Early Use of Covered Self-Expandable Endoscopic Stent on the Treatment of Postoperative Stapler Line Leaks
    (2015) Quezada Sanhueza, Nicolás; Maiz, Cristóbal; Daroch, David; Funke, Ricardo; Sharp Pittet, Allan Carlos; Boza, Camilo; Pimentel Muller, Fernando
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    Emergency right hepatectomy after laparoscopic tru-cut liver biopsy
    (2015) Quezada Sanhueza, Nicolás; León, Felipe; Martínez Castillo, Jorge; Jarufe Cassis, Nicolás; Guerra Castro, Juan Francisco
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    High Frequency of Internal Hernias After Roux-en-Y Gastric Bypass
    (2015) Quezada Sanhueza, Nicolás; León, Felipe; Jones, Alex; Varas, Julián; Funke, Ricardo; Crovari Eulufi, Fernando; Raddatz Echavarría, Alejandro; Pérez Blanco, Gustavo Adolfo; Escalona, Alex; Boza, Camilo; Quezada Sanhueza, Nicolás; León, Felipe; Jones, Alex; Varas, Julián; Funke, Ricardo; Crovari Eulufi, Fernando; Raddatz, Alejandro; Pérez Blanco, Gustavo Adolfo; Escalona, Alex; Boza, Camilo
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    Insulin resistance and liver histopathology in metabolically unhealthy subjects do not correlate with the hepatic abundance of NLRP3 inflammasome nor circulating IL-1β levels
    (2021) Quezada Sanhueza, Nicolás; Valencia, Ilse; Torres, Javiera; Maturana, Gregorio; Cerda, Jaime; Arab Verdugo, Juan Pablo; Fuentes, Juan José; Pinto, Claudio; Turiel, Dannae; Cortes Mora, Víctor Antonio
    Introduction Systemic chronic low-grade inflammation has been linked to insulin resistance (IR) and non-alcoholic steatohepatitis (NASH). NOD-like receptor protein 3 (NLRP3) inflammasome and its final product, interleukin (IL)-1 beta, exert detrimental effects on insulin sensitivity and promote liver inflammation in murine models. Evidence linking hepatic NLRP3 inflammasome, systemic IR and NASH has been scarcely explored in humans. Herein, we correlated the hepatic abundance of NLRP3 inflammasome components and IR and NASH in humans.||Research design and methods Metabolically healthy (MH) (n=11) and metabolically unhealthy (MUH) (metabolic syndrome, n=21, and type 2 diabetes, n=14) subjects were recruited. Insulin sensitivity (homeostatic model assessment of IR (HOMA-IR) and Oral Glucose Sensitivity (OGIS(120))), glycemic (glycated hemoglobin), and lipid parameters were determined by standard methods. Plasma cytokines were quantified by Magpix. Hepatic NLRP3 inflammasome components were determined at the mRNA and protein levels by reverse transcription-quantitative PCR and western blot, respectively. Liver damage was assessed by histological analysis (Non-alcoholic Fatty Liver Disease Activity Score (NAS) and Steatosis, Inflammatory Activity, and Fibrosis (SAF) scores). IR and liver histopathology were correlated with NLRP3 inflammasome components as well as with liver and plasma IL-1 beta levels.||Results Body Mass Index, waist circumference, and arterial hypertension frequency were significantly higher in MUH subjects. These patients also had increased high-sensitivity C reactive protein levels compared with MH subjects. No differences in the plasma levels of IL-1 beta nor the hepatic content of Nlrp3, apoptosis-associated speck-like (Asc), Caspase-1, and IL-1 beta were detected between MUH and MH individuals. MUH subjects had significantly higher NAS and SAF scores, indicating more severe liver damage. However, histological severity did not correlate with the hepatic content of NLRP3 inflammasome components nor IL-1 beta levels.||Conclusion Our results suggest that NLRP3 inflammasome activation is linked neither to IR nor to the inflammatory status of the liver in MUH patients.
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    Laparoscopic hand-sewn revisional gastrojejunal plication for weight loss failure after Roux-en-Y gastric bypass
    (2015) León Salgado, Felipe Ernesto; Maiz, Cristóbal; Daroch, D.; Quezada Sanhueza, Nicolás; Gabrielli Nervi, Mauricio; Muñoz, C.; Boza, Camilo
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    Laparoscopic sleeve gastrectomy conversion to Roux-en-Y gastric bypass : experience in 50 patients after 1 to 3 years of follow-up
    (2016) Quezada Sanhueza, Nicolás; Hernandez, J.; Pérez Blanco, Gustavo Adolfo; Gabrielli Nervi, Mauricio; Raddatz Echavarría, Alejandro; Crovari Eulufi, Fernando; Quezada Sanhueza, Nicolás; Hernandez, J.; Pérez Blanco, Gustavo Adolfo; Gabrielli Nervi, Mauricio; Raddatz, A.; Crovari Eulufi, Fernando
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    Laparoscopic versus open approach in the management of appendicitis complicated exclusively with peritonitis : a single center experience
    (2015) Quezada Díaz, Felipe Fernando; Quezada Sanhueza, Nicolás; Mejía Martínez, Ricardo Javier; Brañes, Alejandro; Padilla Pérez, Oslando; Jarufe Cassis, Nicolás; Pimentel Muller, Fernando
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    Nuevos receptores nucleares heterodiméricos: reguladores metabólicos con impacto en fisiopatología y su proyección terapéutica en dislipidemias y diabetes mellitus
    (2005) Cortés Mora, Víctor Antonio; Quezada Sanhueza, Nicolás; Rigotti Rivera, Attilio; Maiz Gurruchaga, Manuel Alberto
    The regulation of gene expression is crucial for the normal development and the homeostatic maintenance of body tissues. Thus, its malfunction may determine a variety of human disease conditions. A growing body of evidence has shown the overwhelming relevance of a new class of gene expression regulators: the heterodimeric nuclear receptors, a family of structurally related proteins involved in multiple biological functions. In response to activating ligands, these molecules bind to specific genomic regulatory regions where they can coordinately modify the transcriptional activity of several genes involved in the main metabolic pathways of lipids and carbohydrates in cells. These functional properties have stimulated the study of the relationships between heterodimeric nuclear receptors and various disease conditions, such as dyslipidemias and diabetes mellitus. Here we review the experimental, clinical and epidemiological evidences that support the relevance of these transcriptional regulators in the pathophysiology of the most prevalent and lethal diseases in Western countries. We also explore the potential therapeutic impact of new strategies based in the pharmacological modulation of the heterodimeric nuclear receptors
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    Primary leiomyosarcoma of the greater omentum: a case report
    (2016) Brañes, A.; Bustamante, C.; Valbuena Mora, José Rafael; Pimentel Muller, Fernando; Quezada Sanhueza, Nicolás
    Introduction Greater omentum leiomyosarcomas are rare tumors with only a few cases reported in literature. Presentation of case We report the case of a 68-year-old man who consulted complaining of diffuse abdominal pain without a palpable mass at physical examination. Imaging studies revealed a solid-cystic lesion in the right lower quadrant. Surgical resection was performed and the tumor was diagnosed as a leiomyoscarcoma by histological and immunohistochemical examinations. Discussion Surgical resection of all lesions seems to be a reasonable therapeutic approach if resection is feasible. Chemotherapy may be used in selected cases. Conclusion More cases are needed to define the best treatment approach of this disease.
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    Relative lipid oxidation associates directly with mitochondrial fusion phenotype and mitochondria-sarcoplasmic reticulum interactions in human skeletal muscle
    (2020) Castro Sepúlveda, Mauricio; Jannas Vela, S.; Fernández Verdejo, Rodrigo; Ávalos Allele, D.; Tapia, G.; Villagrán, C.; Quezada Sanhueza, Nicolás; Zbinden Foncea, H.
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    Rol de la tomografía computada de abdomen y pelvis con contraste intravenoso en las decisiones clínicas de pacientes con obstrucción de intestino delgado por bridas
    (2014) Quezada Sanhueza, Nicolás; León, F.; Bachler, J.; Riquelme Pizarro, Carlos Rodrigo; Crovari Eulufi, Fernando; Jarufe Cassis, Nicolás; Quezada Sanhueza, Nicolás; León, F.; Bachler, J.; Riquelme, Carlos.; Crovari Eulufi, Fernando; Jarufe Cassis, Nicolás
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    Safety and efficacy of the endoscopic duodenal–jejunal bypass liner prototype in severe or morbidly obese subjects implanted for up to 3 years
    (2018) Quezada Sanhueza, Nicolás; Muñoz Claro, Rodrigo Edgardo; Morelli, Carla; Turiel, Dannae; Hernández, Julián; Pimentel Muller, Fernando; Escalona, Alex
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    Simultaneous TAPP inguinal repair and laparoscopic cholecystectomy: results of a case series
    (2019) Quezada Sanhueza, Nicolás; Maturana, G.; Pimentel, E.; Crovari Eulufi, Fernando; Muñoz, R.; Jarufe Cassis, Nicolás; Pimentel Muller, Fernando
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    Telemedicine for postoperative follow-up, virtual surgical clinics during COVID-19 pandemic
    (2020) Inzunza A., Martín; Muñoz Claro, Rodrigo Edgardo; Quezada Sanhueza, Nicolás; Gabrielli Nervi, Mauricio; Dib Marambio, Martín Javier; Urrejola Schmied, Gonzalo Ignacio; Varas, Julián; Valderrama Chang, Sebastián Matías; Crovari Eulufi, Fernando; Achurra Tirado, Pablo; Irarrázaval Llona, Manuel José; Brañes A.; Soto P.; Inzunza Agüero, Martín Alejandro; Muñoz Claro, Rodrigo; Quezada Sanhueza, Nicolás; Gabrielli Nervi, Mauricio; Dib Marambio, Martín Javier; Urrejola Schmied, Gonzalo Ignacio; Varas, Julián; Valderrama Chang, Sebastián Matías; Crovari Eulufi, Fernando; Achurra Tirado, Pablo; Irarrázaval Llona, Manuel José; Brañes A.; Soto P.
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    Tratamiento laparoscópico de la obstrucción intestinal por bridas
    (2014) Quezada Sanhueza, Nicolás; León, F.; Llera Martin, Juan Carlos de la; Funke, Ricardo; Gabrielli Nervi, Mauricio; Crovari Eulufi, Fernando; Martínez Castillo, Jorge; Boza, Camilo; Jarufe Cassis, Nicolás; Quezada Sanhueza, Nicolás; León, F.; Llera Martin, Juan Carlos de la; Funke, Ricardo; Gabrielli Nervi, Mauricio; Crovari Eulufi, Fernando; Martínez Castillo, Jorge; Boza, Camilo; Jarufe Cassis, Nicolás