Browsing by Author "Ramírez Villanueva, Pablo Antonio"
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- ItemCompassionate use of ruxolitinib in acute and chronic graft versus host disease refractory both to corticosteroids and extracorporeal photopheresis(2017) Sarmiento Maldonado, Mauricio; Bertín Cortes Monroy, Pablo; Jara Arias, Verónica.; Soto Donoso, Katherine.; Uribe González, Pablo Francisco; Ocqueteau Tachini, Mauricio; Ramírez Villanueva, Pablo Antonio; Perez Simón, José Antonio.Abstract Background Ruxolitinib is a potent inhibitor of JAK1/2 with proven efficacy in myelofibrosis. In recent years, research in graft versus host disease (GVHD) has revealed the role of activation of JAK pathways in alloreactive lymphocytes. Some reports have shown significant responses in refractory GVHD patients. Cases presentation In this report we present our experience in 8 patients with acute or chronic GVHD with refractoriness to steroids and extracorporeal photopheresis treated with ruxolitinib. Three patients had acute GVHD (1 pulmonary, 2 cutaneous, 1 multi-systemic) and 5 had chronic GVHD (3 cutaneous); 85% obtained an overall response and 50% a complete response with a tolerable toxicity profile. Conclusions In our series, Ruxolitinib was very active as a rescue therapy for patients with acute or chronic GVHD refractory to standard treatment.
- ItemEarly-Onset EBV-Positive Post-transplant Plasmablastic Lymphoma Arising in a Liver Allograft : A Case Report and Literature Review(2013) Benítez, Carlos; Rey Gnecco, Paula; Zoroquiain Vélez, José Pablo; Martínez Castillo, Jorge; Ramírez Villanueva, Pablo Antonio; Arrese Jiménez, Marco; Pérez Ayuso, Rosa María; Valbuena Mora, José Rafael
- ItemEstudio retrospectivo que compara dosis bajas versus dosis estándar de bortezomib en pacientes con mieloma múltiple(2015) Espinoza Zelada, Marcela; Befferman Cordóva, Nicole; Ocqueteau Tachini, Mauricio; Ramírez Villanueva, Pablo Antonio; Galleguillos, Mauricio; Sarmiento Maldonado, Mauricio
- ItemNutritional assessment as predictor of complications after hematopoietic stem cell transplantation(2016) Espinoza, Marcela; Perelli, Javiera; Olmos, Roberto; Bertín Cortes Monroy, Pablo; Jara, Verónica; Ramírez Villanueva, Pablo Antonio
- ItemOutcomes in relapsed Hodgkin's lymphoma treated with autologous and allogeneic hematopoietic cell transplantation at the Pontificia Universidad Católica de Chile(2015) Ramírez Villanueva, Pablo Antonio; Ocqueteau Tachini, Mauricio; Rodríguez Inglés, María Alejandra; Garcia Zattera, María José; Sarmiento Maldonado, Mauricio; Ernst Diaz, Daniel Matias; Jara, Verónica; Bertín Cortes Monroy, Pablo
- ItemPortal hypertension and acute liver failure as uncommon manifestations of primary amyloidosis(2014) Norero, B.; Perez Ayuso, Rosa Maria; Duarte, Ignacio; Ramírez Villanueva, Pablo Antonio; Soza, Alejandro; Arrese Jiménez, Marco; Benítez, Carlos
- ItemResistance of leukemia cells to cytarabine chemotherapy is mediated by bone marrow stroma, involves cell-surface equilibrative nucleoside transporter-1 removal and correlates with patient outcome(2017) Macanas Pirard, Patricia; Broekhuizen, Richard; González, Alfonso; Oyanadel, Claudia; Ernst Diaz, Daniel Matias; García Cañete, Patricia; Montecinos Acuña, Viviana; Court G., Felipe; Ocqueteau Tachini, Mauricio; Ramírez Villanueva, Pablo Antonio; Nervi, Bruno
- ItemRespuesta y sobrevida en pacientes con leucemia mieloide aguda no candidatos a trasplante tratados con azacitidina versus medidas de soporte: estudio retrospectivo(2015) Sarmiento Maldonado, Mauricio; Ocqueteau Tachini, Mauricio; Pilcante, Javier; Ramírez Villanueva, Pablo Antonio
- ItemThrombotic microangiopathy as first manifestation of acute human immunodeficiency virus infection: a case report and review of the literature(2016) Sarmiento Maldonado, Mauricio; Balcells Marty, María Elvira; Ramírez Villanueva, Pablo AntonioAbstract Background We present the case of a patient with acute human immunodeficiency virus infection and a thrombotic microangiopathy as the first clinical manifestation, a presentation that has not, to the best of our knowledge, been previously reported. Case presentation A 35-year-old Bolivian man presented with epistaxis and thrombocytopenia. We found microangiopathic anemia, lymphopenia, elevated lactate dehydrogenase, progressive acute renal failure, negative direct antiglobulin test, and normal activity of ADAMTS13. An human immunodeficiency virus ELISA test was negative, with an human immunodeficiency virus viral load of 10,000,000 RNA copies/mL. Antiretroviral therapy and three sessions of therapeutic plasma exchange were able to control thrombotic microangiopathy. Conclusions Hematologic manifestations of human immunodeficiency virus infection are frequent. However, the debut of acute human immunodeficiency virus infection with thrombotic microangiopathy is a rare event. A high index of suspicion and early treatment is required.
- ItemUmbilical Cord Blood Transplantation in Hematologic Diseases in Patients Over 15 Years Old : Long-term Experience at the Pontificia Universidad Catolica de Chile(2013) Ramírez Villanueva, Pablo Antonio; Nervi Nattero, Bruno; Bertín Cortes Monroy, Pablo; Poggi, Helena; Lagos, M.; Selman, C.; Pizarro Martínez, Ismael; Jara, V.; Wiestruck, A.; Barriga, Francisco