Browsing by Author "Rey-Jurado, Emma"
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- ItemA single, low dose of a cGMP recombinant BCG vaccine elicits protective T cell immunity against the human respiratory syncytial virus infection and prevents lung pathology in mice(2017) Céspedes, Pablo F.; Rey-Jurado, Emma; Espinoza Véliz, Janyra Alejandra; Rivera, Claudia A.; Canedo Marroquín, Gisela Eliana; Bueno Ramírez, Susan; Kalergis Parra, Alexis Mikes
- ItemAssessing the Importance of Domestic Vaccine Manufacturing Centers: An Overview of Immunization Programs, Vaccine Manufacture, and Distribution(2018) Rey-Jurado, Emma; Tapia, Felipe; Munoz-Durango, Natalia; Lay, Margarita K.; Carreno, Leandro J.; Riedel, Claudia A.; Bueno Ramírez, Susan; Genzel, Yvonne; Kalergis Parra, Alexis Mikes
- ItemContribution of autophagy to antiviral immunity(2015) Rey-Jurado, Emma; Riedel, Claudia A.; Gonzalez, Pablo A.; Bueno Ramírez, Susan; Kalergis Parra, Alexis Mikes
- ItemImmunological Features of Respiratory Syncytial Virus-Caused Pneumonia-Implications for Vaccine Design.(2017) Rey-Jurado, Emma; Pizarro-Ortega, Magdalena S.; Kalergis, Alexis M.The human respiratory syncytial virus (hRSV) is the causative agent for high rates of hospitalizations due to viral bronchiolitis and pneumonia worldwide. Such a disease is characterized by an infection of epithelial cells of the distal airways that leads to inflammation and subsequently to respiratory failure. Upon infection, different pattern recognition receptors recognize the virus and trigger the innate immune response against the hRSV. Further, T cell immunity plays an important role for virus clearance. Based on animal studies, it is thought that the host immune response to hRSV is based on a biased T helper (Th)-2 and Th17 T cell responses with the recruitment of T cells, neutrophils and eosinophils to the lung, causing inflammation and tissue damage. In contrast, human immunity against RSV has been shown to be more complex with no definitive T cell polarization profile. Nowadays, only a humanized monoclonal antibody, known as palivizumab, is available to protect against hRSV infection in high-risk infants. However, such treatment involves several injections at a significantly high cost. For these reasons, intense research has been focused on finding novel vaccines or therapies to prevent hRSV infection in the population. Here, we comprehensively review the recent literature relative to the immunological features during hRSV infection, as well as the new insights into preventing the disease caused by this virus.
- ItemInsights on the crosstalk between dendritic cells and helper T cells in novel genetic etiology for mendelian susceptible mycobacterial disease.(2018) Rey-Jurado, Emma; Pizarro-Ortega, Magdalena S.; Kalergis, Alexis M.; Mendelian susceptibility to mycobacterial disease (MSMD) is an inherited predisposition to infections by Bacille-Calmette Guérin (BCG) vaccine or by environmental mycobacteria. The etiology of MSMD has been associated with up to nineteen different genetic mutations in interferon (IFN)-γ-related genes.1 Although mycobacteria susceptibility-associated genetic mutations are rare in the population, their diagnosis is crucial for an efficient and timely treatment. Kong et al.2 have recently described an autosomal recessive deficiency in the signal.
- ItemRefractory systemic juvenile idiopathic arthritis successfully treated with rapamycin(Oxford University Press, 2021) Concha, Sara; Rey-Jurado, Emma; Poli, M. Cecilia; Hoyos-Bachiloglu, Rodrigo