Browsing by Author "Riquelme, E"

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    Microsatellite instability and loss of heterozygosity have distinct prognostic value for testicular germ cell tumor recurrence
    (TAYLOR & FRANCIS INC, 2004) Velasco, A; Riquelme, E; Schultz, M; Wistuba, II; Villarroel, L; Koh, MS; Leach, FS
    Germ cell tumor (GCT) is the most common genitourinary malignancy of men between the ages of 18 and 35 years. Therapy is ultimately successful in over 90% of patients, however significant morbidity and mortality can be associated with adjuvant treatment and relapse. Molecular markers that predict treatment response and/or poor outcome would have immediate clinical benefit since adjuvant treatment could be selectively reserved for patients at higher risk for relapse and those patients most likely to respond to treatment. In order to identify potential prognostic molecular markers, we evaluated 118 GCT for microsatellite instability (MSI), loss of heterozygosity (LOH) and MSH2 immunostaining to identify tumors associated with relapse and/or poor outcome following initial surgical, medical and/or radiation therapy.