Browsing by Author "Rivera D."

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    Antimicrobial Resistance in Water in Latin America and the Caribbean: Available Research and Gaps
    (Frontiers Media S.A., 2020) Moreno-Switt A.I.; Rivera D.; Moreno-Switt A.I.; Adell A.D.; Rivera D.; Caipo M.L.; Nowell D.C.; Adell A.D.
    Copyright © 2020 Moreno-Switt, Rivera, Caipo, Nowell and Adell.Introduction: Antimicrobial resistance (AMR) is a public health concern that has gained increasing global awareness, and it is estimated that there will be 10 million deaths annually by 2050. The importance of the role of the environment in disseminating clinically relevant AMR is a concern. Although research on AMR in Latin America and the Caribbean (LAC) has been conducted, these data have not been analyzed together to better understand which areas in AMR have been more studied, and which require more attention. Objective: Determine the state of knowledge and identify the information gaps for AMR in water in LAC through an exploratory review that identifies the scientific articles that have addressed the topic. Method: The process of selecting scientific articles from databases consisted of the four phases of an exploratory review focusing on eight themes of interest. Results: The selection process identified 289 studies that were published between 1973 and October 2017, and these studies were included in the analysis. Most of the research was performed from 2008 to 2017. Brazil was the main contributor to the study of AMR in the region while no research was identified in AMR in water in eight of 18 of LAC countries. The most researched topics in water are phenotypic detection of AMR (theme VIII), detection of antimicrobial resistance genes (ARG) (theme V), and degradation of AMR (theme III). Limited research was identified on insects, agricultural products, aquatic organisms, livestock, and wastewater other than hospital wastewater. Research on emerging pests and diseases with a potential impact on the production of AMR (theme VII), impact of the use of antimicrobials on agricultural production (theme IV), and negative effects of AMR on wildlife (theme II) was scarce. Conclusions: We suggest to focus research efforts and resources to study themes I, II, IV, VI, and VII, for which there is little research in LAC, without hindering the valuable research conducted on themes III, V, and VIII. The AMR environmental situation is mainly driven by a few countries that are not representative of the LAC region, and therefore, research is needed in other LAC countries besides Brazil.
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    Bacteriophage-Host Interactions and Coevolution
    (2024) Alvarez-Espejo D.M.; Rivera D.; Moreno-Switt A.I.
    © 2024. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.Bacteriophages are the most abundant entity on the planet and play very relevant roles in the diversity and abundance of their bacterial hosts. These interactions are subject to several factors, such as the first encounter of the phage with its host bacterium, in which molecular interactions are fundamental. Along with this, these interactions depend on the environment and other communities present. This chapter focuses on these phage-bacteria interactions, reviewing the knowledge of the early stage (receptor-binding proteins), host responses (resistance and counter-resistance), and ecological and evolutionary models described to date. In general, knowledge has focused on a few phage-bacteria models and has been deepened by sequencing and metagenomics. The study of phage-bacteria interactions is an essential step for the development of therapies and other applications of phages in the clinical and productive environment.
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    ECOPHAGE: Combating Antimicrobial Resistance Using Bacteriophages for Eco-Sustainable Agriculture and Food Systems
    (Multidisciplinary Digital Publishing Institute (MDPI), 2023) Garcia P.; Tabla R.; Anany H.; Bastias R.; Brondsted L.; Casado S.; Cifuentes P.; Deaton J.; Denes T.G.; Islam M.A.; Lavigne R.; Moreno-Switt A.I.; Nakayama N.; Munoz Madero C.; Sulakvelidze A.; Svircev A.M.; Wagemans J.; Biosca E.G.; Rivera D.
    © 2023 by the authors.The focus of this meeting was to discuss the suitability of using bacteriophages as alternative antimicrobials in the agrifood sector. Following a One Health approach, the workshop explored the possibilities of implementing phage application strategies in the agriculture, animal husbandry, aquaculture, and food production sectors. Therefore, the meeting had gathered phage researchers, representatives of the agrifood industry, and policymakers to debate the advantages and potential shortcomings of using bacteriophages as alternatives to traditional antimicrobials and chemical pesticides. Industry delegates showed the latest objectives and demands from consumers. Representatives of regulatory agencies (European Medicines Agency (EMA) and Spanish Agency of Medicines and Health Products (AEMPS)) presented an update of new regulatory aspects that will impact and support the approval and implementation of phage application strategies across the different sectors.