Browsing by Author "Rocha, Jacqueline"

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    Variation of the gene encoding the nuclear bile salt receptor FXR and gallstone susceptibility in mice and humans
    (ELSEVIER SCIENCE BV, 2008) Kovacs, Peter; Kress, Rahel; Rocha, Jacqueline; Kurtz, Ulrike; Miquel, Juan Francisco; Nervi, Flavio; Mendez Sanchez, Nahum; Uribe, Misael; Bock, Hans H.; Schirin Sokhan, Ramin; Stumvoll, Michael; Moessner, Joachim; Lammert, Frank; Wittenburg, Henning
    Background/Aims: From quantitative trait locus mapping in inbred mice, we identified the Nr1h4 gene encoding the nuclear bile salt receptor FXR as a candidate gene for the cholesterol gallstone susceptibility locus Lith7. Here, we investigated further an association of the gene encoding FXR and gallstone susceptibility in mice and humans.