Browsing by Author "Samith Catalán, Bárbara Patricia"

Now showing 1 - 8 of 8
  • Thumbnail Image
    Item
    Docohexaenoic acid improves the reduced umbilical vein relaxation observed in the offspring of pregnancies with maternal obesity
    (2017) Farías Jofré, Marcelo Enrique; Villalobos Labra, Roberto Esteban; Solari Gajardo, Sandra; Aguirre Polanco, Carolina; Samith Catalán, Bárbara Patricia; Rojas Vidal, María José
    Background and objectives: Maternal obesity (MO) is associated with increased risk of long term metabolic risk in the offspring (REF), probably involving mechanisms such as early programming of insulin resistance in fetal and neonatal tissues. On the other hand, exposure to the polyunsaturated acid Docohexaenoic acid (DHA) has been related with increased insulin response in multiple cell types. The aims of our study were to evaluate the in vitro effect of DHA on vascular response of umbilical vein to insulin, and the role of the intracellular inhibitory phosphorylation of the insulin receptor substrate-1. Methods: Umbilical cords from normal and MO pregnant woman attending to obstetrics service at the Clinical Hospital of Pontificia Universidad Catolica de Chile were obtained after informed consent. Isolated rings of umbilical vein were used to evaluate vasodilatation capacity by wire-myography, in absence or presence of insulin (10-10 to 10-6 uM, 0-20 min) and DHA (100 uM, 12 h). Primary cultures of human umbilical vein endothelial cells (HUVEC) were used to evaluated phosphorylated and total protein levels of IRS-1 in cells exposed or not to insulin (1 nM, 30 min), in absence or presence of DHA (100 uM, 12 h). 308 Ann Nutr Metab 2017;71(suppl 2):1–1433 Oral Abstracts Results: Insulin produces a significant vasodilation (20%) in umbilical vein rings from normal pregnancies, an effect that was absent in MO-derived umbilical rings. This vasodilator effect of insulin was recovered in umbilical vein rings from MO pregnancies pre-incubated with DHA. In addition, HUVEC from MO pregnancies showed increased levels of IRS-1 phosphorylated in serine307, compared with normal cells, a difference that was reduced by DHA, even in presence of insulin. Conclusions: In vitro addition of DHA recovers the reduced vascular response to insulin in umbilical vein from MO pregnancies, involving a reduction of the inhibitory phosphorylation of IRS in serine307.
  • Thumbnail Image
    Item
    Healthy Eating as Potential Mediator of Inverse Association between Purpose in Life and Waist Circumference: Emerging Evidence from US and Chilean Cohorts
    (2023) Berkowitz Fiebich, Loni; Mateo Hernández, Camila; Salazar Vilches, Cristian Javier; Samith Catalán, Bárbara Patricia; Sara Zaror, Daniela Alejandra; Pinto Manzo, Victoria Sabina; Martínez, Ximena; Calzada, Mariana Andrea; Von Schultzendorff Hoyl, Beatriz Andrea; Pedrals, Nuria; Bitrán Carreño, Marcela; Echeverría Errázuriz, Guadalupe; Ruini, Chiara; Ryff, Carol; Rigotti Rivera, Attilio
    High sense of purpose in life, a fundamental domain of eudaimonic well-being, has been consistently associated with lower risk for various obesity-related chronic diseases. Although this psychological feature correlates with some health behaviors as potential mediators, its association with healthy eating remains less explored. In addition, studies of these psycho-behavioral and health relationships in the South American population are lacking. This research sought to assess: (1) the cross-sectional association between self-reported purpose in life and overall healthy eating patterns, and (2) healthy food intake as a potential mediator of the inverse relationship between purpose in life and waist circumference. Data collected of 2060 US adults from the MIDUS study (5 ± 12 years, 55% women, mostly white people, and 42.5% obese) and 223 Chilean adults from the CHILEMED study (46.6 ± 9 years, 58.3% women, and 71.3% obese) were used. Anthropometric and sociodemographic variables were collected. Sense of purpose was assessed using the purpose in life subscale of the Ryff’s psychological well-being questionnaire. Diet quality was evaluated using healthy eating or low-fat diet indexes, according to extant food intake data in each cohort. The relationship between these variables was estimated by bivariate and multivariate linear regressions with appropriate adjustments. To establish whether a better diet quality could mediate a link of purpose in life and improved nutritional status (assessed by waist circumference), the association between these three variables was tested by bootstrapping-based mediation analysis. Our results show significant associations of sense of purpose with healthy eating and low-fat dietary patterns in both US and Chilean cohorts, respectively, even after adjusting for sociodemographic variables. According to the mediation analysis, the relationship between sense of purpose and waist circumference, as an indicator of abdominal obesity, appears to be partially mediated by healthier food intake in both samples. In conclusion, our findings suggest a plausible mechanism underlying the favorable impact of this well-being dimension on physical health. Given its protective effects, interventions aimed at increasing purpose in life may facilitate adherence to better dietary patterns, which, in turn, will reduce the risk for obesity-related chronic diseases.
  • Thumbnail Image
    Item
    La hipótesis de Pedersen no es suficiente : otros nutrientes además de la glucosa explicarían la macrosomía fetal en pacientes diabéticas gestacionales con sobrepeso y buen control glicémico
    (2013) Olmos Coelho, Pablo Roberto; Martelo, G.; Reimer, V.; Rigotti Rivera, Attilio; Busso, Dolores; Belmar Jones, Cristián Gastón; González Pérez, Rogelio Iván; Goldenberg, D.; Samith Catalán, Bárbara Patricia; Santos Martín, José Luis; Escalona, M.; Quezada, T.; Faundez, J.; Nicklitschek, I.
  • Thumbnail Image
    Item
    Limitaciones y oportunidades para la adopción de la dieta mediterránea en adultos chilenos con elementos diagnósticos del síndrome metabólico
    (2024) Calderón, Maribel; Plaza Paz, Gianella; Gómez, Marisol; Samith Catalán, Bárbara Patricia; Pinto Manzo, Victoria Sabina; Martínez Cifuentes, Ximena; Sara Zaror, Daniela Alejandra; Echeverría Errázuriz, Guadalupe; Calzada, Mariana; Berkowitz Fiebich, Loni; Von Schultzendorff Hoyl, Beatriz Andrea; Pedrals, Nuria; Bitrán Carreño, Marcela; Rigotti Rivera, Attilio
    Background: a healthy food intake pattern, specifically the Mediterranean diet (MedDiet), is a factor associated with reduced risk, lower prevalence, and better management of chronic diseases. However, there is limited information regarding how patients integrate proposals for adherence to this food pattern in their daily lives. Objective: to identify factors and conditions that influence adherence to the MedDiet in Chile. Methods: an exploratory qualitative study was applied in 35 to 65-year-old patients of both sexes who presented at least one diagnostic criterion of metabolic syndrome (MetS). Through in-depth interviews and focal groups, knowledge, assessment, attitudes, and practices associated with changes and maintenance of healthy eating habits, with emphasis on the MedDiet, were investigated. Information analysis was carried out under the grounded theory approach using the ATLAS.ti software. Results: participants recognized the value of healthy eating, including the MedDiet, but declared low knowledge (identification of single foods items) together with facilitators (variety of ingredients) and limiting factors (taste, availability/cost of some items, family dynamics) for its routine adoption. In addition, change in eating habits generates a high initial cognitive and emotional load that requires not only individual but also relational effort as it implies modifications of family and collective practices. Conclusions: information obtained on barriers and opportunities to adhere to healthy eating such as the MedDiet is key to design and implement nutritional interventions based on this food pattern and that can be sustainable in time for chronic disease management in Chile.
  • Thumbnail Image
    Item
    Maternal Hypertriglyceridemia : A Link Between Maternal Overweight-Obesity and Macrosomia in Gestational Diabetes
    (2014) Olmos Coelho, Pablo Roberto; Rigotti Rivera, Attilio; Busso, Dolores; Berkowitz Fiebich, Loni; Santos Martín, José Luis; Borzone, Gisella; Poblete L., José A.; Vera Pérez-Gacitúa, Claudio Mauricio; Belmar Jones, Cristián Gastón; Samith Catalán, Bárbara Patricia; Goldenberg, Denisse; Acosta, Ana M.; Escalona, Manuel; Niklitschek, Ian; Mandiola, Jorge R.; Mertens, Nicolás
  • No Thumbnail Available
    Item
    Mediterranean diet and psychological well-being intervention to reverse metabolic syndrome in Chile (CHILEMED trial)
    (2023) Echeverría Errázuriz, Guadalupe; Samith Catalán, Bárbara Patricia; Von Schultzendorff Hoyl, Beatriz Andrea; Pinto Manzo, Victoria Sabina; Martínez Cifuentes, Ximena; Sara Zaror, Daniela Alejandra; Calzada, Mariana; Pacheco Gutiérrez, Josefina; Plaza Paz, Gianella; Scott Escorza, Francesca Angelina; Romero Romero, Javiera Constanza; Mateo Hernández, Camila; Julio Gonzalez, Maria Verónica; Utreras Mendoza, Yildy; Binder Correa, María Victoria; Gutiérrez Medina, Florencia Antonia; Riquelme Stagnaro, María Emilia; Cuevas Guzmán, Margarita María; Willatt, Rosario; Sánchez González, Omayra Margarita De Jesús; Keilendt Astete, Aracelli Tiare; Butron, Patricia; Jarufe Calabrese, Alessandra Antonia; Huete Rubio, Isidora Sofia; Tobar Bavestrello, Josefina Isidora; Martin. Sofía; Alfaro, Valentina; Olivos Celedón, Matilde; Pedrals, Nuria; Bitrán Carreño, Marcela; Ávalos, Ivette; Ruini, Chiara; Ryff, Carol; Pérez Pons, Druso Diego; Berkowitz Fiebich, Loni; Rigotti Rivera, Attilio
    Psychosocial status and lifestyle are key risk factors of non-communicable diseases (NCDs), which, in turn, are main drivers of healthcare costs and morbimortality worldwide, including Chile. Mediterranean diet (MedDiet) is one of the healthiest dietary patterns under study. However, its impact on high-risk conditions, such as metabolic syndrome (MetS), and NCDs outside the Mediterranean Basin remains mostly unexplored. Even though Central Chile has an environment, food production, and culinary traditions comparable to those present in Mediterranean countries, few studies -some with significant methodological limitations- have evaluated the effect of MedDiet on health and/or disease in Chilean subjects. Importantly, a Mediterranean lifestyle is a modus vivendi that integrates physical health with mental and social well-being. Psychological well-being (PWB) is associated with healthy behaviors, positive health outcomes, and longevity, thereby emerging as a novel healthcare goal. We report here an ongoing randomized controlled clinical trial in Chilean patients with MetS seeking to test whether (1) a PWB theory-based intervention facilitates induction to and increases long-term adherence to a locally adapted MedDiet, and (2) a MedDiet intervention -implemented alone or combined with well-being promotion- is more effective at reversing MetS compared to individuals following a low-fat diet without psychological support. The CHILEan MEDiterranean (CHILEMED) diet intervention study is a 1-year trial including patients with MetS living in Chile. Participants will be assigned randomly by a computer-generated random number sequence to one of the three intervention arms: a) low-fat diet as control group, b) MedDiet alone, and c) MedDiet plus well-being support. Patients will be followed-up by individual and/or group online nutritional sessions or phone cal as well as 6- and 12-month in-person re-assessment of medical history, medication use, food intake, PWB, anthropometrics/physical exam, and blood collection for laboratory analysis. The primary outcome of the trial will be the effect of the MedDiet -with or without PWB intervention- on overall reversal of MetS compared to low-fat diet alone. Based on a statistical superiority trial, expected impact, and patient loss, the estimated study sample is 339 subjects (113 individuals per arm in 3 equal-sized groups). Currently, we have enrolled 179 patients, predominantly women, evenly distributed by age (group means ranging from 45.7 to 48,9 years-old), 3/4 are obese with almost all of them showing abdominal obesity, 70% are hypertensive, whereas <10% exhibit diabetes. If findings turn out as expected (e.g., MedDiet -with or without PWB intervention- is better than the low-fat diet for reversion of MetS at 1-year follow-up), CHILEMED will provide further beneficial evidence of the MedDiet on NCD risk conditions beyond the Mediterranean region.
  • Thumbnail Image
    Item
    Mediterranean Lifestyle to Promote Physical, Mental, and Environmental Health: The Case of Chile
    (2020) Echeverría Errázuriz, Guadalupe; Tiboni Oschilewski, Ornella; Berkowitz Fiebich, Loni; Pinto Manzo, Victoria Sabina; Samith Catalán, Bárbara Patricia; Von Schultzendorff Hoyl, Beatriz Andrea; Pedrals, Nuria; Bitrán Carreño, Marcela; Ruini, Chiara; Ryff, Carol D.; Del Rio, Daniele; Rigotti Rivera, Attilio
    Chile is currently experiencing a progressive epidemiological transition towards chronic diseases. In this country, >50% of annual deaths are attributed to cardiovascular disease and cancer. Moreover, health surveys have shown high prevalence of obesity, diabetes, hypertension, and elevated cardiovascular disease risk. In addition, mental health issues are also frequent among Chilean adults. On the other hand, the agri-food system contributes to 21-37% of greenhouse gases emissions worldwide. Overall, current health and food chain situation calls out for design and implementation of evidence-based feasible and effective nutritional interventions needed to promote physical and mental health along with addressing food sustainability in Chile. Nowadays, the Mediterranean diet is recognized as one of the healthiest dietary patterns based on observational and interventional studies linked to a wide variety of health outcomes. However, a Mediterranean lifestyle goes well beyond food intake: it includes promotion of psychosocial resources, community life as well as cultural traditions. Indeed, Mediterranean lifestyle is a true modus vivendi that integrally promotes physical, mental, and social well-being. In addition, the Mediterranean diet stands out for its environmental sustainability because it is characterized mainly as a plant-based dietary pattern with low carbon and water footprints. Remarkably, Central Chile has a Mediterranean-like setting with plant and animal food production and availability patterns comparable to those present in countries located around the Mediterranean Sea. Therefore, this article reviews how promotion of Mediterranean lifestyle adherence in Chile offers great potential for management of the ongoing epidemiological transition to chronic diseases as well to promote psychological well-being within a unique food system and dietary sustainability vision for this Latin American country.
  • No Thumbnail Available
    Item
    Reduced docosahexaenoic acid content in neonatal erythrocytes from obese mothers
    (2017) Samith Catalán, Bárbara Patricia; Farías Jofré, Marcelo Enrique; Villalobos Labra, Roberto Esteban; Solari Gajardo, Sandra; Aguirre Polanco, Carolina; Rojas Reyes, María José