Browsing by Author "Slevin, G"

Now showing 1 - 1 of 1
  • Thumbnail Image
    Item
    Muc1 and glycan expression in the oviduct and endometrium of a new world monkey, Cebus apella
    (OXFORD UNIV PRESS INC, 2001) Jones, CJP; Ortiz, ME; Croxatto, HB; Manzur, A; Slevin, G; Aplin, JD
    Cebus apella is a New World monkey that has a menstrual cycle of 18-23 days with implantation at approximately luteal Day 5, The aim of this study was to characterize by lectin- and antibody-labeling the distribution of Mud and associated glycans on the endometrial and oviductal epithelium during the luteal phase of the cycle, Endometrial histology showed a thin endometrium, with glands extending deeply into the myometrium, No obvious evidence of secretory differentiation in cells of either the superficial or the basal segments of glands could be obtained using a panel of antibodies and lectins that marked epithelial glycoprotein, and glycosylation changes observed in some other primate endometrial cycles were not observed in this study, Antibodies to human MUC1 were shown to cross-react with C, apella, and Mud was localized to the apical epithelial surfaces of both the endometrial and the tubal epithelium, with stronger expression in the latter. Again, no cyclic changes were noted, Antibodies specific to the isoform Muc1/Sec showed strong staining at the apical tubal epithelium, but no reactivity was detectable in the luminal epithelium of the uterus. This observation suggests differences between the two glycocalyces and could help to explain why C, apella embryos do not implant in this location.