Browsing by Author "Soto, E."

Now showing 1 - 7 of 7
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    A rapid MMP-8 bedside test for the detection of intra-amniotic inflammation identifies patients at risk for imminent preterm delivery
    (2006) Nien, J. K.; Yoon, B. H.; Espinoza, J.; Kusanovic, Juan Pedro; Erez, O.; Soto, E.; Richani, K.; Gómez Mora, Ricardo Alberto; Hassan, S.; Mazor, M.; Edwin, S.; Bahado-Singh, R.; Romero, R.
    Objective: Matrix metalloproteinase-8 (MMP-8) is an enzyme that is released during neutrophil activation. MMP-8 amniotic fluid concentrations are elevated not only in patients with intra-amniotic infection, but also in patients with negative amniotic fluid cultures who deliver preterm neonates. The objective of this study was to determine whether the results of a rapid MMP-8 bedside test predict imminent preterm delivery. This test can be performed in 15 minutes and without laboratory equipment. Study design: Amniotic fluid was retrieved from 331 patients admitted with increased preterm uterine contractions and intact membranes who met the inclusion criteria. Amniotic fluid was processed for microbial cultures, Gram stain, glucose concentration, and white blood cell count. Amniotic fluid samples were stored, and the MMP-8 rapid test was performed after delivery. End points included spontaneous preterm delivery within 48 hours, 7 days, and 14 days. Diagnostic indices, predictive values, and likelihood ratios were calculated. Results: The prevalence of spontaneous preterm delivery within 48 hours, 7 days, and 14 days was 11.6% (38/327), 20.2% (66/327), and 24.5% (80/327), respectively (4 patients with augmentation of labor were excluded). A positive MMP-8 rapid test had a positive predictive value of 70% (23/33) for the identification of patients who delivered spontaneously within 48 hours, and 94% (31/33) for patients who were delivered within 7 days and 14 days (likelihood ratios: 17.5 [95% CI, 9-33.9], 61.3 [95% CI, 15.1-250], and 50 [95% CI, 12-196], respectively). Conclusion: The MMP-8 rapid test can identify patients at risk for preterm delivery within 7 days and 14 days. Moreover, a positive MMP-8 rapid test result can identify patients with intraamniotic infection/inflammation with a high sensitivity and specificity. This rapid test will give clinicians a fast and accurate assessment of the inflammatory status of the amniotic cavity and allow for better identification of patients at risk for impending preterm delivery.
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    Effect of the side-chain structure on the glass-transition temperature .3. Molecular-weight dependence of tg in some poly(thiocarbonates)
    (1988) Gargallo Gómez, Ligia Teresita; Soto, E.; Tagle Domínguez, Luis Hernán; Radić Foschino, Deodato D.; Gargallo Gómez, Ligia Teresita; Soto, E.; Tagle Domínguez, Luis Hernán; Radić Foschino, Deodato D.
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    Effect of the side-chain structure on the glass-transition temperatures of some poly(thiocarbonate)s
    (1986) Yazdani-Pedram, M.; Soto, E.; Tagle Domínguez, Luis Hernán; Díaz Alzamora, Fernando Raúl; Gargallo Gómez, Ligia Teresita; Radić Foschino, Deodato D.; Yazdani-Pedram, M.; Soto, E.; Tagle Domínguez, Luis Hernán; Díaz Alzamora, Fernando Raúl; Gargallo Gómez, Ligia Teresita; Radić Foschino, Deodato D.
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    Maternal plasma concentrations of angiogenic/antiangiogenic factors in the third trimester of pregnancy to identify the patient at risk for stillbirth at or near term and severe late preeclampsia
    (2013) Chaiworapongsa, T.; Romero, R.; Korzeniewski, S.; Kusanovic, Juan Pedro; Soto, E.; Lam, J.; Dong, Z.; Than, N.; Yeo, L.; Hernández Andrade, E.; Conde Agudelo, A.; Hassan, S.
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    Resistin: A hormone which induces insulin resistance is increased in normal pregnancy
    (2007) Nien, J.K.; Mazaki-Tovi, S.; Romero, R.; Kusanovic, J.P.; Erez, O.; Gotsch, F.; Pineles, B.L.; Friel, L.A.; Espinoza, J.; Goncalves, L.; Santolaya, J.; Gomez, R.; Hong, J.-S.; Edwin, S.; Soto, E.; Richani, K.; Mazor, M.; Hassan, S.S.
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    The identification of two subgroups of obese women with differing endometrial proliferation levels: potential consequences in the development of endometrial cancer
    (2012) Villavicencio, A.; Aguilar, G.; Acuna, J.; Gabler, F.; Soto, E.; Gaete, F.; Penaloza, P.; Celis, M.; Owen, G. I.
    Enhanced endometrial proliferation correlates obesity to type-I (estrogen-dependent) endometrial cancer (EC). Our aim was to distinguish obese women (without EC) with differing endometrial proliferation. Endometrial and blood samples were obtained from normal-weight and obese women without EC. Type-I EC samples were obtained from obese patients. On measuring endometrial proliferation (Ki67 and phosphorylated histone H3 (p-H3)), two groups of obese women without EC were identified: obese(High Proliferating) (O-HP) and obese(Low Proliferating) (O-LP). Increased Ki67 (88.5%, P<0.001), p-H3 (62.6%, P<0.01), 17 beta-estradiol/progesterone ratio (46.3%, P<0.01) and endometrial estrogen receptor alpha (ER alpha) (82.2%, P<0.001) were observed in O-HP compared with O-LP patients. ECs possessed similar ER alpha and enhanced proliferation as O-HP, suggesting that O-HP women are at higher risk of type-I EC. O-LP women were indistinguishable from normal-weight women regarding these determinants of endometrial proliferation, ER alpha and 17 beta-estradiol/progesterone ratio. Our data may further define the obesity phenotype in regards to type-I EC risk and may help identify obese women more susceptible to develop type-I EC, allowing early intervention and a potential reduction in mortality.
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    Twin-to-twin transfusion syndrome: an antiangiogenic state?
    (2008) Kusanovic, J.P.; Romero, R.; Espinoza, J.; Nien, J.K.; Kim, C.J.; Mittal, P.; Edwin, S.; Erez, O.; Gotsch, F.; Mazaki-Tovi, S.; Than, N.G.; Soto, E.; Camacho, N.; Gomez, R.; Quintero, R.; Hassan, S.S.