Browsing by Author "Tapia, Diego"

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    A Novel Learning-Based Binarization Scheme Selector for Swarm Algorithms Solving Combinatorial Problems
    (2021) Lemus-Romani, Jose; Becerra-Rozas, Marcelo; Crawford, Broderick; Soto, Ricardo; Cisternas-Caneo, Felipe; Vega, Emanuel; Castillo, Mauricio; Tapia, Diego; Astorga, Gino; Palma, Wenceslao; Castro, Carlos; Garcia, Jose
    Currently, industry is undergoing an exponential increase in binary-based combinatorial problems. In this regard, metaheuristics have been a common trend in the field in order to design approaches to successfully solve them. Thus, a well-known strategy includes the employment of continuous swarm-based algorithms transformed to perform in binary environments. In this work, we propose a hybrid approach that contains discrete smartly adapted population-based strategies to efficiently tackle binary-based problems. The proposed approach employs a reinforcement learning technique, known as SARSA (State-Action-Reward-State-Action), in order to utilize knowledge based on the run time. In order to test the viability and competitiveness of our proposal, we compare discrete state-of-the-art algorithms smartly assisted by SARSA. Finally, we illustrate interesting results where the proposed hybrid outperforms other approaches, thus, providing a novel option to tackle these types of problems in industry.
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    Fecal cortisol levels predict breeding but not survival of females in the short-lived rodent, Octodon degus
    (2013) Ebensperger, Luis A.; Tapia, Diego; Ramirez-Estrada, Juan; Leon, Cecilia; Soto-Gamboa, Mauricio; Hayes, Loren D.
    The cort-adaptation hypothesis indicates that an association between glucocorticoid (cort) levels and fitness may vary with the extent to which reproduction or breeding effort is a major determinant of cort levels. Support for a context dependent association between cort and fitness comes mostly from relatively long-lived, bird species. We tested the hypothesis that there are gender and context (life-history) specific cort-fitness relationships in degus, a short-lived and generally semelparous social rodent. In particular, we used demographical records on a natural population to estimate adult survival through seasons and years and linked that to records of baseline cort (based on fecal cortisol metabolites). We found no evidence for a direct relationship between baseline cort and adult survival across seasons, and this lack of association was recorded irrespective of sex and life history stage. Yet, cort levels during early lactation predicted the probability that females produce a second litter during the same breeding season, supporting a connection between baseline cort levels and breeding effort. Overall, the differential effects of cort on survival and breeding supported that the extent of cort-fitness relationships depends on the fitness component examined. (C) 2013 Published by Elsevier Inc.
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    KDEL receptor regulates secretion by lysosome relocation- and autophagy-dependent modulation of lipid-droplet turnover
    (2019) Tapia, Diego; Zamora, Constanza; Espinoza, Javier; Rizzo, Riccardo; González Cárdenas, Alexis; Fuentes Peña, Danitza Natalia; Hernández, Sergio; Cavieres, Viviana A.; Guzmán, Fanny; Arriagada, Gloria; Yuseff Sepúlveda, María Isabel; Mardones, Gonzalo A.; Burgos , Patricia V.; Luini, Alberto; González, Alfonso; Cancino, Jorge; Jiménez, Tomás; Soza Gajardo, Andrea