Browsing by Author "Torres, M"
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- ItemCharacterization and trypanocidal activity of nifurtimox-containing and empty nanoparticles of polyethylcyanoacrylates(ROYAL PHARMACEUTICAL SOC GREAT BRITAIN, 1998) Gonzalez Martin, G; Merino, I; Rodriguez Cabezas, MN; Torres, M; Nunez, R; Osuna, AThe aim of this study was to evaluate the utility of nanoparticles of polyalkylcyanoacrylate as a targeted delivery system for nifurtimox against Trypanosoma cruzi, responsible for Chagas' disease. Ethylcyanoacrylate nanoparticles were prepared by an emulsion polymerization process and formulations containing different concentrations of nifurtimox, polyethylcyanoacrylates and surfactants were investigated and analysed for size and drug content.
- ItemReactions of dichloromethane with thioanions .2. Formation of 5-alkyl-1,3,5-dithiazinanes, 3,5-dialkyl-1,3,5-thiadiazinanes, and 1,3,5-trialkyl-1,3,5-triazinanes by reaction of dichloromethane with sodium sulfide and monoalkylamines(GORDON BREACH SCI PUBL LTD, 1995) Torres, M; Vega, JCThe reaction of dichloromethane with sodium sulfide and monoalkylamines, catalyzed by polyethyleneglycol 1,500, is studied. A mixture of 5-alkyl-1,3,5-dithiazinane, 3,5-dialkyl-1,3,5-thiadiazinane, and 1,3,5-trialkyl-1,3,5-triazinane is obtained. The proportion of these heterocycles depends on the amine structure and the presence of sodium hydroxide.