Browsing by Author "Valenzuela, F. J."

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    Increased placental angiogenesis in late and early onset pre-eclampsia is associated with differential activation of vascular endothelial growth factor receptor 2
    (W B SAUNDERS CO LTD, 2014) Escudero, C.; Celis, C.; Saez, T.; San Martin, S.; Valenzuela, F. J.; Aguayo, C.; Bertoglia, P.; Roberts, J. M.; Acurio, J.
    Introduction: Placentas from both early-onset (EOPE) and late-onset pre-eclampsia (LOPE) exhibit signs of underperfusion, which in turn, may be associated with altered angiogenesis. Tyrosine 951 (Y951) and Y1175 phosphorylation of the vascular endothelial growth factor receptor 2 (VEGFR2) induced by VEGF triggers the angiogenesis process. Endothelial markers such as CD31 and CD34 have been used for estimating angiogenic processes in several tissues, including placenta. We asked whether vascular density in placental villi was related to Y951/Y1175 phosphorylation of VEGFR2 in LOPE or EOPE.