Browsing by Author "Valverde, Israel"

Now showing 1 - 19 of 19
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    3D printed cardiovascular models for surgical planning in complex congenital heart diseases
    (2015) Valverde, Israel; Gomez, Gorka; Suarez-Mejias, Cristina; Hosseinpour, Amir-Reza; Hazekamp, Mark; Roest, Arno; Vazquez-Jimenez, Jaime F; El-Rassi, Issam; Uribe Arancibia, Sergio A.; Gomez-Cia, Tomas
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    3D Printed Models for Planning Endovascular Stenting in Transverse Aortic Arch Hypoplasia
    (2015) Valverde, Israel; Gómez, Gorka; Coserria, Jose Felix; Suarez Mejias, Cristina; Uribe Arancibia, Sergio A.; Sotelo Parraguez, Julio Andrés; Velasco, Maria Nieves; De Soto, Jose Santos; Hosseinpour, Amir Reza; Gómez Cia, Tomas
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    3D Quantification of Wall Shear Stress and Oscillatory Shear Index Using a Finite-Element Method in 3D CINE PC-MRI Data of the Thoracic Aorta
    (2016) Sotelo Parraguez, Julio Andrés; Urbina, Jesus; Valverde, Israel; Tejos Nunez, Cristian Andres; Irarrázaval Mena, Pablo; Andia Kohnenkampf, Marcelo Edgardo; Uribe Arancibia, Sergio A.; Hurtado Sepúlveda, Daniel
    Several 2D methods have been proposed to estimate WSS and OSI from PC-MRI, neglecting the longitudinal velocity gradients that typically arise in cardiovascular flow, particularly on vessel geometries whose cross section and centerline orientation strongly vary in the axial direction. Thus, the contribution of longitudinal velocity gradients remains understudied. In this work, we propose a 3D finite-element method for the quantification of WSS and OSI from 3D-CINE PC-MRI that accounts for both in-plane and longitudinal velocity gradients. We demonstrate the convergence and robustness of the method on cylindrical geometries using a synthetic phantom based on the Poiseuille flow equation. We also show that, in the presence of noise, the method is both stable and accurate. Using computational fluid dynamics simulations, we show that the proposed 3D method results in more accurate WSS estimates than those obtained from a 2D analysis not considering out-of-plane velocity gradients. Further, we conclude that for irregular geometries the accurate prediction of WSS requires the consideration of longitudinal gradients in the velocity field. Additionally, we compute 3D maps of WSS and OSI for 3D-CINE PC-MRI data sets from an aortic phantom and sixteen healthy volunteers and two patients. The OSI values show a greater dispersion than WSS, which is strongly dependent on the PC-MRI resolution. We envision that the proposed 3D method will improve the estimation of WSS and OSI from 3D-CINE PC-MRI images, allowing for more accurate estimates in vessels with pathologies that induce high longitudinal velocity gradients, such as coarctations and aneurisms.
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    A realistic MR compatible aortic phantom to validate hemodynamic parameters from MRI data: aortic coarctation patients comparison using catheterization
    (2015) Urbina, Jesus; Sotelo Parraguez, Julio Andrés; Tejos Núñez, Cristián Andrés; Irarrázaval Mena, Pablo; Andía Kohnenkampf, Marcelo Edgardo; Razavi, Reza; Valverde, Israel; Uribe Arancibia, Sergio A.
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    Caval Blood Flow Distribution in Patients with Fontan Circulation : Quantification by Using Particle Traces from 4D Flow MR Imaging
    (2013) Bächler, Pablo; Valverde, Israel; Pinochet, Natalia; Nordmeyer, Sarah; Kuehne, Titus; Crelier, Gérard; Tejos Núñez, Cristián Andrés; Irarrázaval Mena, Pablo; Beerbaum, P.; Uribe Arancibia, Sergio A.
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    Congenital Heart Disease in Children: Coronary MR Angiography during Systole and Diastole with Dual Cardiac Phase Whole-Heart Imaging
    (RADIOLOGICAL SOC NORTH AMERICA, 2011) Uribe, Sergio; Hussain, Tarique; Valverde, Israel; Tejos, Cristian; Irarrazaval, Pablo; Fava, Mario; Beerbaum, Philipp; Botnar, Rene M.; Razavi, Reza; Schaeffter, Tobias; Greil, Gerald F.
    Purpose: To assess the optimal timing for coronary magnetic resonance (MR) angiography in children with congenital heart disease by using dual cardiac phase whole-heart MR imaging.
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    Flow-sensitive four-dimensional magnetic resonance imaging facilitates the quantitative analysis of systemic-to-pulmonary collateral flow in patients with univentricular hearts
    (2012) Uribe Arancibia, Sergio A.; Nordmeyer, Sarah; Valverde, Israel; Greil, Gerald F.; Berger, Felix; Kuehne, Titus; Beerbaum, Philipp B.
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    Hemodynamic Assessment in Patients with One-and-a-Half Ventricle Repair Revealed by Four-Dimensional Flow Magnetic Resonance Imaging
    (2013) Uribe Arancibia, Sergio A.; Bächler, Pablo; Valverde, Israel; Crelier, Gérard R.; Beerbaum, Philipp; Tejos Núñez, Cristián Andrés; Irarrázaval Mena, Pablo
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    Impact of aortic arch curvature in flow haemodynamics in patients with transposition of the great arteries after arterial switch operation
    (2022) Sotelo, Julio; Valverde, Israel; Martins, Duarte; Bonnet, Damien; Boddaert, Nathalie; Pushparajan, Kuberan; Uribe, Sergio; Raimondi, Francesca
    Aims In this study, we will describe a comprehensive haemodynamic analysis and its relationship to the dilation of the aorta in transposition of the great artery (TGA) patients post-arterial switch operation (ASO) and controls using 4D-flow magnetic resonance imaging (MRI) data. Methods and results Using 4D-flow MRI data of 14 TGA young patients and 8 age-matched normal controls obtained with 1.5 T GE-MR scanner, we evaluate 3D maps of 15 different haemodynamics parameters in six regions; three of them in the aortic root and three of them in the ascending aorta (anterior-left, -right, and posterior for both cases) to find its relationship with the aortic arch curvature and root dilation. Differences between controls and patients were evaluated using Mann-Whitney U test, and the relationship with the curvature was accessed by unpaired t-test. For statistical significance, we consider a P-value of 0.05. The aortic arch curvature was significantly different between patients 46.238 +/- 5.581 m(-1) and controls 41.066 +/- 5.323 m(-1). Haemodynamic parameters as wall shear stress circumferential (WSS-C), and eccentricity (ECC), were significantly different between TGA patients and controls in both the root and ascending aorta regions. The distribution of forces along the ascending aorta is highly inhomogeneous in TGA patients. We found that the backward velocity (B-VEL), WSS-C, velocity angle (VEL-A), regurgitation fraction (RF), and ECC are highly correlated with the aortic arch curvature and root dilatation. Conclusion We have identified six potential biomarkers (B-VEL, WSS-C, VEL-A, RF, and ECC), which may be helpful for follow-up evaluation and early prediction of aortic root dilatation in this patient population.
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    Improving congenital heart disease imaging using 3d whole-heart dual-phase MRI
    (2011) Hussain, Tarique; Uribe Arancibia, Sergio A.; Lossnitzer, Dirk; Bellsham-Revell, Hannah; Valverde, Israel; Razavi, Reza; Beerbaum, Phillip; Bell, Aaron; Botnar, René Michael; Schaeffter, Tobias
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    Quantification of pulmonary regurgitation in patients with repaired Tetralogy of Fallot by 2D phase-contrast MRI: Differences between the standard method of velocity averaging and a pixel-wise analysis
    (2017) Sotelo Parraguez, Julio Andrés; Bächler, Pablo; Urbina, Jesús; Crelier, Gerard; Toro Rosas, Lida Elba Graciela; Ferreiro, Myriam; Valverde, Israel; Andía Kohnenkampf, Marcelo Edgardo; Tejos Núñez, Cristián Andrés; Irarrázaval Mena, Pablo; Uribe Arancibia, Sergio A.
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    Quantification of wall shear stress using a finite-element method in multidimensional phase-contrast MR data of the thoracic aorta
    (2015) Sotelo Parraguez, Julio Andrés; Urbina, Jesús; Valverde, Israel; Tejos Núñez, Cristián Andrés; Irarrázaval Mena, Pablo; Hurtado Sepúlveda, Daniel; Uribe Arancibia, Sergio A.
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    Realistic aortic phantom to study hemodynamics using MRI and cardiac catheterization in normal and aortic coarctation conditions
    (2016) Urbina, Jesús; Sotelo Parraguez, Julio Andrés; Springmüller P., Daniel; Montalba, Cristian; Letelier, Karis; Tejos Núñez, Cristián Andrés; Irarrázaval Mena, Pablo; Andía Kohnenkampf, Marcelo Edgardo; Razavi, Reza; Valverde, Israel; Uribe Arancibia, Sergio A.
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    Three-dimensional patient-specific cardiac model for surgical planning in Nikaidoh procedure
    (2015) Valverde, Israel; Gómez, Gorka; González, Antonio; Suárez Mejías, Cristina; Adsuar, Alejandro; Coserria, José Félix; Uribe Arancibia, Sergio A.; Gómez-Cia, Tomás; Hosseinpour, Amir Reza
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    Three-dimensional printed models for surgical planning of complex congenital heart defects: an international multicentre study
    (2017) Valverde, Israel; Gómez Ciriza, Gorka; Hussain, Tarique; Suárez Mejías, Cristina; Velasco Forte, María N.; Byrne, Nicholas; Ordoñez, Antonio; González Calle, Antonio; Anderson, David; Uribe Arancibia, Sergio A.
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    Three-dimensional quantification of vorticity and helicity from 3D cine PC-MRI using finite-element interpolations
    (2018) Sotelo Parraguez, Julio Andrés; Urbina, Jesús; Valverde, Israel; Mura Mardones, Joaquín Alejandro; Tejos Núñez, Cristián Andrés; Irarrázaval Mena, Pablo; Andía Kohnenkampf, Marcelo Edgardo; Hurtado Sepúlveda, Daniel; Uribe Arancibia, Sergio A.
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    Tissue engineered in-vitro vascular patch fabrication using hybrid 3D printing and electrospinning
    (2022) Mayoral, Isabel; Bevilacqua, Elisa; Gomez, Gorka; Hmadcha, Abdelkrim; Gonzalez-Loscertales, Ignacio; Reina, Esther; Sotelo, Julio; Dominguez, Antonia; Perez-Alcantara, Pedro; Smani, Younes; Gonzalez-Puertas, Patricia; Mendez, Ana; Uribe, Sergio; Smani, Tarik; Ordonez, Antonio; Valverde, Israel
    Three-dimensional (3D) engineered cardiovascular tissues have shown great promise to replace damaged structures. Specifically, tissue engineering vascular grafts (TEVG) have the potential to replace biological and synthetic grafts. We aimed to design an in-vitro patient-specific patch based on a hybrid 3D print combined with vascular smooth muscle cells (VSMC) differentiation. Based on the medical images of a 2 months-old girl with aortic arch hypoplasia and using computational modelling, we evaluated the most hemodynamically efficient aortic patch surgical repair. Using the designed 3D patch geometry, the scaffold was printed using a hybrid fused deposition modelling (FDM) and electrospinning techniques. The scaffold was seeded with multipotent mesenchymal stem cells (MSC) for later maturation to derived VSMC (dVSMC). The graft showed adequate resistance to physiological aortic pressure (burst pressure 101 +/- 15 mmHg) and a porosity gradient ranging from 80 to 10 mu m allowing cells to infiltrate through the entire thickness of the patch. The bio-scaffolds showed good cell viability at days 4 and 12 and adequate functional vasoactive response to endothelin-1. In summary, we have shown that our method of generating patient-specific patch shows adequate hemodynamic profile, mechanical properties, dVSMC infiltration, viability and functionality. This innovative 3D biotechnology has the potential for broad application in regenerative medicine and potentially in heart disease prevention.
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    Validation of 4D Flow based relative pressure maps in aortic flows
    (2021) Nolte, David; Urbina, Jesus; Sotelo, Julio; Sok, Leo; Montalba, Cristian; Valverde, Israel; Osses, Axel; Uribe, Sergio; Bertoglio, Cristobal
    While the clinical gold standard for pressure difference measurements is invasive catheterization, 4D Flow MRI is a promising tool for enabling a non-invasive quantification, by linking highly spatially resolved velocity measurements with pressure differences via the incompressible Navier-Stokes equations. In this work we provide a validation and comparison with phantom and clinical patient data of pressure difference maps estimators. We compare the classical Pressure Poisson Estimator (PPE) and the new Stokes Estimator (STE) against catheter pressure measurements under a variety of stenosis severities and flow intensities. Specifically, we use several 4D Flow data sets of realistic aortic phantoms with different anatomic and hemodynamic severities and two patients with aortic coarctation. The phantom data sets are enriched by subsampling to lower resolutions, modification of the segmentation and addition of synthetic noise, in order to study the sensitivity of the pressure difference estimators to these factors. Overall, the STE method yields more accurate results than the PPE method compared to catheterization data. The superiority of the STE becomes more evident at increasing Reynolds numbers with a better capacity of capturing pressure gradients in strongly convective flow regimes. The results indicate an improved robustness of the STE method with respect to variation in lumen segmentation. However, with heuristic removal of the wall-voxels, the PPE can reach a comparable accuracy for lower Reynolds' numbers. (c) 2021 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ )
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    Variability of 4D flow parameters when subjected to changes in MRI acquisition parameters using a realistic thoracic aortic phantom
    (2018) Montalba, Cristian; Urbina, Jesus; Sotelo Parraguez, Julio Andrés; Andía Kohnenkampf, Marcelo Edgardo; Tejos Núñez, Cristián Andrés; Irarrázaval Mena, Pablo; Hurtado Sepúlveda, Daniel; Valverde, Israel; Uribe Arancibia, Sergio A.