Browsing by Author "Varela Nallar, Lorena Patricia"
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- ItemAdult Hippocampal Neurogenesis in Aging and Alzheimer's Disease(2010) Varela Nallar, Lorena Patricia; Aranguiz Correa, Florencia.; Slater Guzmán, Paula Gabriela; Inestrosa Cantín, Nibaldo
- ItemCalcium/Calmodulin-Dependent Protein Kinase Type IV Is a Target Gene of the Wnt/beta-Catenin Signaling Pathway(2009) Arrazola Tello, Macarena Soledad.; Varela Nallar, Lorena Patricia; Colombres Raby, Marcela.; Inestrosa Cantín, Nibaldo
- ItemChronic hypoxia induces the activation of the Wnt/beta-catenin signaling pathway and stimulates hippocampal neurogenesis in wild-type and APPswe-PS1 Delta E9 transgenic mice in vivo(2014) Varela Nallar, Lorena Patricia; Rojas Abalos, Macarena; Abbott, Ana C.; Moya, Esteban A.; Iturriaga Agüera, Rodrigo; Inestrosa Cantín, Nibaldo
- ItemFrizzled Receptors in Neurons: From Growth Cones to the Synapse(2012) Varela Nallar, Lorena Patricia; Ramírez Fernández, Valerie Trinidad.; Inestrosa Cantín, Nibaldo
- ItemFrizzled-5 Receptor Is Involved in Neuronal Polarity and Morphogenesis of Hippocampal Neurons(2013) Slater Guzmán, Paula Gabriela; Ramírez Fernández, Valerie Trinidad.; Varela Nallar, Lorena Patricia; Inestrosa Cantín, Nibaldo
- ItemFrizzled‐1 is involved in the neuroprotective effect of Wnt3a against Aβ oligomers(2008) Chacón Rojas, Marcelo.; Varela Nallar, Lorena Patricia; Inestrosa Cantín, Nibaldo
- ItemFructose consumption reduces hippocampal synaptic plasticity underlying cognitive performance(2015) Cisternas, Pedro; Salazar, Paulina; Serrano, Felipe G.; Montecinos Oliva, Carla; Arredondo, Sebastián B.; Varela Nallar, Lorena Patricia; Barja Y., Salesa; Vio Lagos, Carlos P.; Gomez Pinilla, Fernando; Inestrosa Cantín, Nibaldo
- ItemLocal Klotho enhances neuronal progenitor proliferation in the adult hippocampus(2017) Salech, F.; Varela Nallar, Lorena Patricia; Arredondo, S. B.; Bustamante, D.; Andaur, G. A.; Cisneros, R.; Ponce, D.; Ayala, P.; Inestrosa Cantín, Nibaldo; Valdes, J.; Behrens, M.; Couve, A.
- ItemNeurobiological Effects of Hyperforin and its Potential in Alzheimer's Disease Therapy(2010) Griffith, T. N.; Varela Nallar, Lorena Patricia; Dinamarca Ceballos, Margarita Constanza.; Inestrosa Cantín, Nibaldo
- ItemPSD95 suppresses dendritic arbor development in mature hippocampal neurons by occluding the clustering of NR2B-NMDA receptors(2014) Varela Nallar, Lorena Patricia; Inestrosa Cantín, Nibaldo
- ItemRole of the Wnt receptor Frizzled-1 in presynaptic differentiation and function(2009) Varela Nallar, Lorena Patricia; Grabowski, Catalina P.; Alfaro, Iván E.; Álvarez Rojas, Alejandra; Inestrosa Cantín, NibaldoAbstract Background The Wnt signaling pathway regulates several fundamental developmental processes and recently has been shown to be involved in different aspects of synaptic differentiation and plasticity. Some Wnt signaling components are localized at central synapses, and it is thus possible that this pathway could be activated at the synapse. Results We examined the distribution of the Wnt receptor Frizzled-1 in cultured hippocampal neurons and determined that this receptor is located at synaptic contacts co-localizing with presynaptic proteins. Frizzled-1 was found in functional synapses detected with FM1-43 staining and in synaptic terminals from adult rat brain. Interestingly, overexpression of Frizzled-1 increased the number of clusters of Bassoon, a component of the active zone, while treatment with the extracellular cysteine-rich domain (CRD) of Frizzled-1 decreased Bassoon clustering, suggesting a role for this receptor in presynaptic differentiation. Consistent with this, treatment with the Frizzled-1 ligand Wnt-3a induced presynaptic protein clustering and increased functional presynaptic recycling sites, and these effects were prevented by co-treatment with the CRD of Frizzled-1. Moreover, in synaptically mature neurons Wnt-3a was able to modulate the kinetics of neurotransmitter release. Conclusion Our results indicate that the activation of the Wnt pathway through Frizzled-1 occurs at the presynaptic level, and suggest that the synaptic effects of the Wnt signaling pathway could be modulated by local activation through synaptic Frizzled receptors.
- ItemThe Cellular Prion Protein Prevents Copper-Induced Inhibition of P2X(4) Receptors.(2011) Lorca, R. A.; Varela Nallar, Lorena Patricia; Inestrosa Cantín, Nibaldo; García-Huidobro Toro, Juan Pablo
- ItemThe role of WNT signaling in neuroprotection(2009) Cerpa Nebott, Waldo Francisco; Varela Nallar, Lorena Patricia; Inestrosa Cantín, Nibaldo
- ItemThe ROR2 tyrosine kinase receptor regulates dendritic spine morphogenesis in hippocampal neurons(2015) Alfaro, Iván E.; Varela Nallar, Lorena Patricia; Varas Godoy, Manuel; Inestrosa Cantín, Nibaldo
- ItemWnt-5a Is a Synaptogenic Factor with Neuroprotective Properties against A beta Toxicity(2012) Varela Nallar, Lorena Patricia; Parodi Rivera, Jorge Luis.; Farías Galdames, Ginny Cheryl.; Inestrosa Cantín, Nibaldo
- ItemWnt5a promotes differentiation and development of adult-born neurons in the hippocampus by noncanonical Wnt signaling(2020) Arredondo, S. B.; Guerrero, F. G.; Herrera Soto, A.; Jensen Flores, J.; Bustamante, D. B.; Oñate Ponce, A.; Henny V., Pablo; Varas Godoy, M.; Inestrosa Cantín, Nibaldo; Varela Nallar, Lorena Patricia