Browsing by Author "Velasco, A"

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    Microsatellite instability and loss of heterozygosity have distinct prognostic value for testicular germ cell tumor recurrence
    (TAYLOR & FRANCIS INC, 2004) Velasco, A; Riquelme, E; Schultz, M; Wistuba, II; Villarroel, L; Koh, MS; Leach, FS
    Germ cell tumor (GCT) is the most common genitourinary malignancy of men between the ages of 18 and 35 years. Therapy is ultimately successful in over 90% of patients, however significant morbidity and mortality can be associated with adjuvant treatment and relapse. Molecular markers that predict treatment response and/or poor outcome would have immediate clinical benefit since adjuvant treatment could be selectively reserved for patients at higher risk for relapse and those patients most likely to respond to treatment. In order to identify potential prognostic molecular markers, we evaluated 118 GCT for microsatellite instability (MSI), loss of heterozygosity (LOH) and MSH2 immunostaining to identify tumors associated with relapse and/or poor outcome following initial surgical, medical and/or radiation therapy.
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    Molecular alterations in primary prostate cancer after androgen ablation therapy
    (AMER ASSOC CANCER RESEARCH, 2005) Best, CJM; Gillespie, JW; Yi, YJ; Chandramouli, GVR; Perlmutter, MA; Gathright, Y; Erickson, HS; Georgevich, L; Tangrea, MA; Duray, PH; Gonzalez, S; Velasco, A; Linehan, WM; Matusik, RJ; Price, DK; Figg, WD; Emmert Buck, MR; Chuaqui, RF
    Purpose: After an initial response to androgen ablation, most prostate tumors recur, ultimately progressing to highly aggressive androgen-independent cancer. The molecular mechanisms underlying progression are not well known in part due to the rarity of androgen-independent Samples from primary and-metastatic sites.