Browsing by Author "Vera-Salazar, Roberto F."

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    Age- and Sex-Associated Glucose Metabolism Decline in a Mouse Model of Alzheimer's Disease
    (2022) Gherardelli, Camila; Cisternas, Pedro; Vera-Salazar, Roberto F.; Mendez-Orellana, Carolina; Inestrosa, Nibaldo C.
    Background: Alzheimer's disease (AD) is characterized by a high etiological and clinical heterogeneity, which has obscured the diagnostic and treatment efficacy, as well as limited the development of potential drugs. Sex differences are among the risk factors that contribute to the variability of disease manifestation. Unlike men, women are at greater risk of developing AD and suffer from higher cognitive deterioration, together with important changes in pathological features. Alterations in glucose metabolism are emerging as a key player in the pathogenesis of AD, which appear even decades before the presence of clinical symptoms.