Browsing by Author "Vergara, C."
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- ItemCa2+-activated K+ channel inhibition by reactive oxygen species(2002) Soto Arriaza, Marco; González, C.; Lissi, E.; Vergara, C.; Latorre, R.
- ItemCOVID-19 L·OVE REPOSITORY IS HIGHLY COMPREHENSIVE AND CAN BE USED AS A SINGLE SOURCE FOR COVID-19 STUDIES(2021) Verdugo Paiva, Francisca; Vergara, C.; Ávila, Camila; Castro, J.; Cid, J.; Contreras, V.; Jara, I.; Jiménez, Valentina; Ha Lee, Min; Muñoz, Magdalena; Rojas Gómez, Ana María; Roson Rodríguez, P.; Serrano Arevalo, K.; Silva Ruz, Ivan; Vásquez Laval, J.; Zambrano Achig, Paula; Zavadzki, Giovanna; Rada G., GabrielObjective: COVID-19 Living OVerview of Evidence (COVID-19 L·OVE) is a public repository and classification platform for COVID-19 articles. The repository contains over 430,000 articles as of 20 September 2021 and intends to provide a one-stop shop for COVID-19 evidence. Considering that systematic reviews conduct high-quality searches, this study assesses the comprehensiveness and currency of the repository against the total number of studies in a representative sample of COVID-19 systematic reviews. Methods: Our sample was generated from all the studies included in the systematic reviews of COVID-19 published during April 2021. We estimated the comprehensiveness of COVID-19 L·OVE repository by determining how many of the individual studies in the sample were included in the COVID-19 L·OVE repository. We estimated the currency as the percentage of studies that were available in the COVID-19 L·OVE repository at the time the systematic reviews conducted their own search. Results: We identified 83 eligible systematic reviews that included 2132 studies. COVID-19 L·OVE had an overall comprehensiveness of 99.67% (2125/2132). The overall currency of the repository, that is, the proportion of articles that would have been obtained if the search of the reviews was conducted in COVID-19 L·OVE instead of searching the original sources, was 96.48% (2057/2132). Both the comprehensiveness and the currency were 100% for randomised trials (82/82). Conclusion: The COVID-19 L·OVE repository is highly comprehensive and current. Using this repository instead of traditional manual searches in multiple databases can save a great amount of work to people conducting systematic reviews and would improve the comprehensiveness and timeliness of evidence syntheses. This tool is particularly important for supporting living evidence synthesis processes.
- ItemEducational website incorporating rheumatoid arthritis patient needs for Latin American and Caribbean countries(2017) Massone Moya, Francisca Beatriz; Martínez, M. E.; Pascual, V.; Quintana, R.; Stange, L.; Caballero, C.; Ferreyra, L.; Kourilovitch, M.; Duarte, M.; Baumert, C.; Vergara, C.; Gareca, N.; Rodríguez, C.; Khoury, V.; Medina, M.; Cardiel, M.; Massardo Vega, Loreto
- ItemFLAVONOL PROFILES FOR VARIETAL DIFFERENTIATION BETWEEN CARMENERE AND MERLOT WINES PRODUCED IN CHILE: HPLC AND CHEMOMETRIC ANALYSIS(SOC CHILENA QUIMICA, 2011) Vergara, C.; Von Baer, D.; Mardones, C.; Gutierrez, L.; Hermosin Gutierrez, I.; Castillo Munoz, N.Wine differentiation is an important issue for the Chilean winemaking industry, especially for the Carmenere variety, which was rediscovered in this country around 20 years ago. Authentication parameters are required for this wine due to its frequent confusion with Merlot. The concentration of anthocyanins, shikimic acid, and the principal flavonols found in wine allowed some varietal differentiation between Carmenere and Merlot wines. Myricetin and quercetin are the most concentrated flavonols in wine in which they are present in free and conjugated forms. These compounds are responsible for important wine antioxidant properties. In the present work, using only the concentrations of free and conjugated quercetin and myricetin, differentiation between Carmenere and Merlot varieties was better achieved. Flavonol profiles of wine produced in Chile were studied with HPLC-DAD-ESI-MSn. An overview of the concentration range of flavonols present in 248 Chilean red wines is presented, finding that the mean concentration of the sum of total myricetin and total quercetin were higher in Carmenere (81.5 mgL(-1)) and Merlot (78.9 mgL(-1)) than in Cabernet Sauvignon (53.9 mgL(-1)) wines. These mean levels were higher than the majority of the concentrations reported in the literature. The chemometric analysis shows that the ratio of total quercetin/total myricetin combined with the concentration of free myricetin allowed the varietal differentiation between Carmenere and Merlot wines.
- ItemImproving Chilean In-service Elementary Teachers’ Understanding of Nature of Science Using Self-contained NOS and Content-Embedded Mini-Courses(2014) Cofre, H.; Vergara, C.; Lederman, N.; Lederman, J.; Santibanez, D.; Jimenez, J.; Yancovic Allen, Macarena Alejandra
- ItemMechanism of Pyrogallol Red Oxidation Induced by Free Radicals and Reactive Oxidant Species. A Kinetic and Spectroelectrochemistry Study(2013) Atala, E.; Velasquez, G.; Vergara, C.; Mardones, C.; Reyes, J.; Tapia Apati, Ricardo; Quina, F.; Mendes, M.; Speisky, Hernán; Lissi, E.; Ureta Zañartu, M.; Aspee, A.; López Alarcón, Camilo Ignacio
- ItemNeural language models for text classification in evidence-based medicine(2020) Carvallo, A.; Parra Santander, Denis Alejandro; Rada, G.; Pérez, D.; Vásquez, J.I.; Vergara, C.