Browsing by Author "Vergara Saavedra, Ismael Antonio"

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    Dolor torácico y alteración electrocardiográfica
    (2017) Paredes, Alejandro; Bittner Braemer, Alex Gerhard; Vergara Saavedra, Ismael Antonio
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    Identification of novel transcripts with differential dorso-ventral expression in Xenopus gastrula using serial analysis of gene expression
    (2009) Faunes Quinteros, Fernando Emerson; Vergara Saavedra, Ismael Antonio; Melo Ledermann, Francisco Javier; Larraín Correa, Juan Agustín
    Background: Recent evidence from global studies of gene expression indicates that transcriptomes are more complex than expected. Xenopus has been typically used as a model organism to study early embryonic development, particularly dorso-ventral patterning. In order to identify novel transcripts involved in dorso-ventral patterning, we compared dorsal and ventral transcriptomes of Xenopus tropicalis at the gastrula stage using serial analysis of gene expression ( SAGE).
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    Impacto de un programa de rehabilitación cardiovascular fase II sobre la calidad de vida de los pacientes
    (2017) Bustamante, M. J.; Acevedo B., Mónica; Valentino Peirano, Giovanna Francesca; Casasbellas, C.; Saavedra, M. J.; Adasme, M.; Orellana, L.; Vergara Saavedra, Ismael Antonio; Corbalán Herreros, Ramón; Navarrete, C.
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    Reverse Remodeling in Human Heart Failure after Cardiac Resynchronization Therapy Is Associated With Reduced RHO-Kinase Activation
    (2021) Ocaranza Jeraldino, Maria Paz; Jalil Milad, Jorge Emilio; Altamirano Assad, Rodrigo Patricio; De León Soto, Ana María; Moya López, Jackeline Trinidad; Lonis Álvarez, María Alejandra; Gabrielli Nervi, Luigi Arnaldo; Mac Nab, Paul; Cordova Alvestegui, Samuel Edmundo; Paredes, Alejandro; Vergara Saavedra, Ismael Antonio; Bittner Braemer, Alex Gerhard; Sabat Sarras, Karime Alejandra; Pastorini, Karla
    ["Background: Reverse remodeling is a clinically relevant endpoint in heart failure with reduced ejection fraction (HFrEF). Rho-kinase (ROCK) signaling cascade activation correlates with cardiac remodeling and left ventricular (LV) systolic dysfunction in HFrEF patients. Cardiac resynchronization therapy (CRT) is effective in HFrEF, especially when there is a left bundle block, as this treatment may stimulate reverse remodeling, thereby improving quality of life and prolonging survival for patients with this severe condition. Here, we evaluate the hypothesis that ROCK activation is reduced after effective CRT in HFrEF.", "Methods: ROCK activation in circulating leukocytes was evaluated in 28 HFrHF patients, using Western blot (myosin light chain phosphatase subunit 1 phosphorylation, MYPT1p/t), before and three months after initiation of CRT. LV systolic function and remodeling were assessed by echocardiography.", "Results: Three months after CRT, LV ejection fraction increased an average of 14.5% (p < 0.001) in 13 patients (responders), while no change was observed in 15 patients (non-responders). End-systolic diameter decreased 16% (p < 0.001) in responders, with no change in non-responders. ROCK activation in PBMCs decreased 66% in responders (p < 0.05) but increased 10% in non-responders (NS). LV end-diastolic diameter was also 5.2 mm larger in non-responders vs. responders (p = 0.058). LV ejection fraction, systolic diameter, and ROCK activation levels were similar in both groups at baseline.", "Conclusion: In HFrEF patients, 3 months of effective CRT induced reverse myocardial remodeling, and ROCK activation was significantly decreased in circulating leukocytes. Thus, decreased ROCK activation in circulating leukocytes may reflect reverse cardiac remodeling in patients with heart failure."]
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    Terapia de resincronización en pacientes con insuficiencia cardiaca : Experiencia acumulada de 10 años
    (2013) Enriquez, A.; Barrero, R.; Bittner, Alex; Frangini Sanhueza, Patricia Andrea; Baeza, M.; Millapan, I.; González Aldunate, Rolando; Vergara Saavedra, Ismael Antonio