Browsing by Author "Villarroel, Alejandra"
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- ItemA simple method to assess estrogen receptor gene (ESR1) amplification in paired biopsies from primary tumor and recurrence in breast cancer patients receiving endocrine therapy(2020) Maiz, Cristóbal; Oddó, David; Alfaro, Francisca; Villarroel, Alejandra; Acevedo, Francisco; Pérez Sepulveda, Alejandra; Muñiz, Sabrina; Silva, Fernando; Valdivia, Andrés; Merino, Tomas; Pinto, Mauricio P.; Sánchez, CésarGlobally, Breast Cancer (BC) is the leading cause of cancer death among women. About 75% of patients are diagnosed with hormone-dependent tumors and are set to receive Endocrine Therapy (ET) targeting the estrogen receptor. Unfortunately, a significant proportion of these patients develops ET resistance. Still controversial, studies have proposed that Estrogen Receptor-Alpha Gene (ESR1) alterations may underlie ET resistance. Here, we describe the use of a Chromogenic in Situ Hybridization (CISH) assay for the assessment of ESR1 amplification in primary tumors and recurrences. This assay could be a useful clinical tool with therapeutic implications for estrogen receptor positive BC patients.
- ItemBreast lesions with atypia in percutaneous biopsies, managed with surgery in the last 10 years(2019) Carrillo, Mitzy; Maturana, Gregorio; Maiz, Cristobal; Romero, Diego; Dominguez, Francisco; Oddo, David; Villarroel, Alejandra; Razmilic, Dravna; Elena Navarro, Maria; Leon, Augusto; Sanchez, Cesar; Camus, MauricioIntroduction: The optimal management of breast lesions with atypia (BLA), detected in percutaneous biopsies after screening mammograms, is a controversial issue. The aim of this paper is to compare histological diagnosis by percutaneous biopsy with the results of the surgical biopsy of these lesions and to analyse the changes to clinical approach this would imply.
- ItemCan histological grade and mitotic index replace Ki67 to determine luminal breast cancer subtypes?(2018) Oddo Benavides, David; Pulgar, Dahiana; Peña, José; Acevedo Claros, Francisco Nicolás; Razmilic Valdés, Dravna Nichi; Navarro Ortega, María Elena; Camus Appuhn, Mauricio Gonzalo; Merino Lara, Tomas Rodrigo; Sánchez, César; Pérez Sepúlveda, Alejandra Andrea; Villarroel, Alejandra; Galindo, Héctor; Elgueta, Nicole; Retamal, Ignacio
- ItemCoryneform Bacteria in Granulomatous Lobular Mastitis: Morphological Diagnosis in Breast Biopsies(2019) Oddo, David; Stefanelli, Angeles; Villarroel, Alejandra; Mendez, Gonzalo P.Granulomatous lobular mastitis is a rare disease whose origin is still unknown and shows an increase in its frequency. Morphological, microbiological, and molecular biology studies have linked this disease to lipophilic and fastidious corynebacteria, suggesting its possible infectious etiology. This series describes and reviews in detail the distinctive morphological characteristics of the bacteria present in the granulomas of this disease, the usefulness of histochemical techniques for their identification, and our proposal for a tissue quantification score for the bacteria. The MacCallum-Goodpasture method of Gram's stain turned out to be the gold standard for examination, but we also highlight the efficiency of hematoxylin and eosin stain when it is exhaustively examined as well as the Grocott stain to evaluate the bacterial pleomorphism method, which is often underutilized.
- ItemMelanocytic BAP-1-Mutated Atypical Intradermal Tumor in Two Siblings: A Case Report(2020) Kolbach-Rengifo, Marianne; Alfaro-Sepulveda, Daniela; Villarroel, Alejandra; Martin-Parada, Celeste; Gonzalez-Bombardiere, SergioMelanocytic BAP-1-mutated atypical intradermal tumor (MBAIT) is a tumor that appears early on life. It can be the first manifestation of a tumor predisposition syndrome. Prompt diagnosis will allow for the implementation of early screening techniques for associated malignancies. We present a case of 2 siblings with MBAITs and their future management.
- ItemPatient inflammatory status and CD4+/CD8+ intraepithelial tumor lymphocyte infiltration are predictors of outcomes in high-grade serous ovarian cancer(2018) Pinto, Mauricio P.; Balmaceda, Carlos; Bravo Castillo, María Loreto; Kato Cardemil, Sumie Rode; Villarroel, Alejandra; Owen, Gareth Ivor; Roa Strauch, Juan Carlos Enrique; Cuello F., Mauricio; Ibañez, Carolina
- ItemRisk factors for loco-regional recurrence in breast cancer patients: A retrospective study(2018) Merino Lara, Tomas Rodrigo; Ip, Teresa; Domínguez Covarrubias, Francisco José; Acevedo Claros, Francisco Nicolás; Medina Araya, Lidia; Villarroel, Alejandra; Camus Appuhn, Mauricio Gonzalo; Vinés Vásquez, Eugenio; Sánchez Rojel, César Giovanni
- ItemSurvival rates of advanced estrogen-receptor positive breast cancer. Analysis of 211 cases(2020) Sanchez, Cesar; Dominguez, Francisco; Galindo, Hector; Camus, Mauricio; Oddo, David; Villarroel, Alejandra; Razmilic, Dravna; Pena, Jose; Elena Navarro, Maria; Medina, Lidia; Merino, Tomas; Briones, Juan; Acevedo, FranciscoBackground: About 80% of breast cancer (BC) cases express estrogen receptor (ER), which has been correlated with good prognosis and response to estrogen deprivation Aim: To characterize ER positive advanced BC (ABC) patients treated at our institution assessing the impact of clinical presentation (stage IV, de novo disease at diagnosis versus systemic recurrence) and BC subtype on survival rates. Material and Methods: We evaluated 211 ER+ advanced BC (ABC) patients, treated between 1997 and 2017. Results: The median overall survival (OS) was 37 months. Median OS for the period 1997/2006 and 2007/2017 were 33 and 42 months, respectively (p = 0.47). Luminal A, ABC stage IV disease at diagnosis displayed better OS rates than Luminal B stage IV tumors (100 and 32 months respectively, p < 0.01). Conclusions: Clinical presentation (stage IV vs. systemic recurrence) and tumor subtype are key determinants of OS in ABC.