Browsing by Author "Waissbluth, Sofia"

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    Audiological follow-up in transplant patients treated with calcineurin immunosuppressants "Calcineurin inhibitors and Ototoxicity"
    (2023) Heider, Claudia; Waissbluth, Sofia; Oyarzun, Javier A.; Calderara, Gabriela; Leung, Jai-Sen; Novoa, Ivan
    Background: Ototoxicity is a side effect of drugs and medications that usually leads to bilateral and symmetric sensorineural hearing loss that commonly affects the high-frequency range initially, with or preceded by tinnitus. Possible ototoxic side effects of calcineurin inhibitor immunosuppressants have been suggested, but this remains unclear. Therefore, this study aims to evaluate audiological changes in patients undergoing transplantation receiving immunosuppressive treatment with calcineurin inhibitors. Methods: Prospective cohort study. Adult patients undergoing liver or kidney transplantation treated with calcineurin inhibitors were included. Pure-tone audiometry, distortion product otoacoustic emissions, and the Tinnitus Handicap Inventory questionnaire were completed at baseline, one, three, and six months after transplantation. Hearing thresholds were compared and correlated with plasma concentrations of calcineurin inhibitors. Results: Seventeen patients were included, 59% males, with a median age of 54.7 years (29-68 years). Twelve patients underwent liver transplantation, four underwent kidney transplantation, and one patient underwent both. The median follow-up was 5.8 months (4-8 months). Significant pure-tone average shifts were observed in two patients. Both cases presented fluctuations in their hearing levels, which were not bilateral or symmetrical and affected the higher frequencies. All patients received tacrolimus within the therapeutic range during the follow-up period. Three different patients exceeded the expected range once; however, they were rapidly corrected and did not correlate with any changes in hearing. Conclusions: It appears that tacrolimus does not cause hearing loss when levels are within the therapeutic range for a follow-up period of six months post-transplantation.
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    Benign Paroxysmal Positional Vertigo Secondary to Acute Unilateral Peripheral Vestibulopathy: Evaluation of Cardiovascular Risk Factors
    (2023) Waissbluth, Sofia; Becker, Javier; Sepulveda, Valeria; Iribarren, Javier; Garcia-Huidobro, Francisco
    BACKGROUND: Lindsay-Hemenway syndrome was first described as an acute unilateral peripheral vestibulopathy followed by positional vertigo. A vascular etiology was proposed. An association between cardiovascular risk factors and benign paroxysmal positional vertigo secondary to acute unilateral peripheral vestibulopathy has been described with contradictory evidence. The study aimed to evaluate the prevalence of cardiovascular risk factors in patients with benign paroxysmal positional vertigo secondary to acute unilateral peripheral vestibulopathy and analyze differences in prior history of benign paroxysmal positional vertigo, affected semicircular canals, and response to repositioning maneuvers between patients with idiopathic benign paroxysmal positional vertigo and secondary to acute unilateral peripheral vestibulopathy. METHODS: We performed a retrospective, descriptive study of all cases of benign paroxysmal positional vertigo between January/2017 and June/2020, with or without a history of acute unilateral peripheral vestibulopathy within the previous year. Cases secondary to trauma or otoneurological causes and acute unilateral peripheral vestibulopathy without confirmatory tests and cases with auditory symptoms were excluded. RESULTS: In total, 242 cases were obtained; 158 idiopathic benign paroxysmal positional vertigo and 84 secondary to acute unilateral peripheral vestibulopathy. No statistically significant differences were found in relation to age: 61.2 +/- 14.6 versus 62.4 +/- 16.2 years (P =.55), sex: female 78.5% versus 73.8% (P =.41), presence of cardiovascular risk factors: 52.5% versus 54.8% (P =.67), prior history of benign paroxysmal positional vertigo: 22.2% versus 27.7% (P =.43), affected semicircular canals (P =.16) or number of repositioning maneuvers (P =.57). CONCLUSION: Associations between age, cardiovascular risk factors, and benign paroxysmal positional vertigo secondary to acute unilateral peripheral vestibulopathy have been described with conflicting evidence. This is the first study to evaluate cardiovascular risk factors specifically for Lindsay-Hemenway syndrome, and we did not observe any differences between idiopathic benign paroxysmal positional vertigo cases and those secondary to acute unilateral peripheral vestibulopathy.
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    Caloric and video head impulse test dissociated results in dizzy patients
    (2022) Waissbluth, Sofia; Sepulveda, Valeria; Leung, Jai-Sen; Oyarzun, Javier
    IntroductionWe are now able to detect abnormalities for any semicircular canal with the use of the video head impulse test (vHIT). Prior to the vHIT, the gold standard for unilateral canal paresis of the lateral canal was considered the caloric test. Clinical cases where the caloric test and vHIT are discordant are not uncommon. MethodsRetrospective study. All consecutive cases of dizziness seen from 11/2020 to 12/2021 for which the patient underwent both caloric and vHIT tests performed within 10 days, were reviewed. Patients with discordant results were included. We evaluated the caloric response, vHIT gains for all canals and saccades, with and without gain abnormalities. ResultsWe included 74 cases of dizziness with dissociated results. The most common finding was a normal caloric response with abnormal vHIT results (60.8%); the main abnormal finding on vHIT was the presence of saccades. In this group, 37.7% of patients had normal gains and refixation saccades. In addition, the most found low gain was for the posterior canal. The main diagnosis in this group was vestibular migraine. For the group with unilateral caloric paresis and normal vHIT gain in the lateral canal, the main diagnosis was Meniere's disease. DiscussionThe most common disorders with discordant results were Meniere's disease and vestibular migraine. The caloric test and vHIT are complementary and combining both tests provide greater clinical information. Further research is needed to understand refixation saccades with normal gains.
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    Case Report: Isolated Idiopathic Saccular Dysfunction
    (2021) Waissbluth, Sofia; Oyarzun, Javier
    Advances in vestibular testing have now allowed us to test each semicircular canal as well as the utricle and saccule, independently. This has led to the discovery of new patterns of vestibular dysfunction that were once impossible to evaluate. This report describes the case of a 20-year-old woman with a 2-month history of recurrent dizziness. She had a complete audiovestibular assessment. The only abnormality observed was the absence of a cervical vestibular-evoked myogenic potential response for the right side, hence an isolated saccular dysfunction. In conclusion, isolated otolithic dysfunction is probably an overlooked and neglected clinical presentation. Its true incidence is unknown, and further research is needed to understand this clinical entity.
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    Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study
    (2021) Simoes, Joana F. F.; Nepogodiev, Dmitri; Ademuyiwa, Adesoji; Buarque, Igor; El-Boghdadly, Kariem; Gebreyohanes, Mengistu; Glasbey, James C.; Kronberger, E.; Kruijff, Schelto; Li, Elizabeth; Loeffler, Markus; Mashbari, Hassan; Pata, Francesco; Smart, Neil; Sayyed, Raza; Shu, Sebastian; Sund, Malin; Bhangu, Aneel; Simoes, Joana; Ahmed, Waheed-Ul-Rahman; Argus, Leah; Ball, Alasdair; Bhangu, Aneel; Bywater, Edward P.; Blanco-Colino, Ruth; Brar, Amanpreet; Chaudhry, Daoud; Dawson, Brett E.; Duran, Irani; Elhadi, Muhammed; Glasbey, James C.; Gujjuri, Rohan R.; Jones, Conor S.; Harrison, Ewen M.; Kamarajah, Sivesh K.; Keatley, James M.; Lawday, Samuel; Li, Elizabeth; Mann, Harvinder; Marson, Ella J.; Mclean, Kenneth A.; Nepogodiev, Dmitri; Norman, Lisa; Ots, Riinu; Outani, Oumaima; Picciochi, Maria; Santos, Irene; Shaw, Catherine; Simoes, Joana F. F.; Taylor, Elliott H.; Trout, Isobel M.; Varghese, Chris; Venn, Mary L.; Xu, William; Dajti, Irida; Gjata, Arben; Kacimi, Salah Eddine Oussama; Boccalatte, Luis; Cox, Daniel; Pockney, Peter; Townend, Philip; Aigner, Felix; Kronberger, Irmgard Elisabeth; Samadov, Elgun; Alderazi, Amer; Hossain, Kamral; Padmore, Greg; van Ramshorst, Gabrielle; Lawani, Ismail; Cerovac, Anis; Delibegovic, Samir; Baiocchi, Glauco; Ataide Gomes, Gustavo Mendonca; Buarque, Igor Lima; Gohar, Muhammad; Slavchev, Mihail; Nwegbu, Chukwuemeka; Agarwal, Arnav; Brar, Amanpreet; Martin, Janet; Ng-Kamstra, Joshua; Marta Modolo, Maria; Olivos, Maricarmen; Lou, Wenhui; Ren, Dong-Lin; Andres Calvache, Jose; Rivera, Carlos J-Perez; Hadzibegovic, Ana Danic; Kopjar, Tomislav; Mihanovic, Jakov; Aviles Jimenez, Pablo Mijahil; Gouvas, Nikolaos; Klat, Jaroslav; Novysedlak, Rene; Amisi, Nicolas; Christensen, Peter; El-Hussuna, Alaa; Batista, Sylvia; Lincango-Naranjo, Eddy; Emile, Sameh; Arevalo Sandoval, Danilo Alfonso; Dhufera, Hailu; Hailu, Samuel; Mengesha, Mengistu G.; Kauppila, Joonas H.; Arnaud, Alexis P.; Demetrashvili, Zaza; Albertsmeier, Markus; Lederhuber, Hans; Loeffler, Markus W.; Acquah, Daniel Kwesi; Ofori, Bernard; Tabiri, Stephen; Metallidis, Symeon; Tsoulfas, Georgios; Aguilera-Arevalo, Maria-Lorena; Recinos, Gustavo; Mersich, Tamas; Wettstein, Daniel; Ghosh, Dhruva; Kembuan, Gabriele; Milan, Peiman Brouki; Khosravi, Mohammad Hossein; Mozafari, Masoud; Hilmi, Ahmed; Mohan, Helen; Zmora, Oded; Gallo, Gaetano; Pata, Francesco; Pellino, Gianluca; Fujimoto, Yuki; Kuroda, Naoto; Satoi, Sohei; Abou Chaar, Mohamad K.; Ayasra, Faris; Fakhradiyev, Ildar; Hamdun, Intisar Hisham Said; Jin-Young, Jang; Jamal, Mohammad; Karout, Lina; Elhadi, Muhammed; Gulla, Aiste; Rasoaherinomenjanahary, Fanjandrainy; Samison, Luc Herve; Roslani, April Camilla; Duran Sanchez, Iran Irani; Samantha Gonzalez, Diana; Martinez, Laura; Jose Martinez, Maria; Nayen, Alejandra; Ramos-De la Medina, Antonio; Nunez, Jade; Outani, Oumaima; Nashidengo, Pueya Rashid; Shah, Rakesh; Shrestha, Ashish Lal; Jonker, Pascal; Kruijff, Schelto; Noltes, Milou; Steinkamp, Pieter; Varghese, Chris; Wright, Deborah; Abdur-Rahman, Lukman; Ademuyiwa, Adesoji; Adisa, Adewale; Osinaike, Babatunde; Seyi-Olajide, Justina; Williams, Omolara; Williams, Emmanuel; Pejkova, Sofija; Al Balushi, Zainab; Qureshi, Ahmad Uzair; Sayyed, Raza; Mohsen, Mustafa Abo; Abukhalaf, Sadi A.; Cukier, Moises; Gomez-Fernandez, Hugo; Shu Yip, Sebastian; Vasquez Ojeda, Ximena Paola; Dione Sacdalan, Marie; Major, Piotr; Azevedo, Jose; Cunha, Miguel F.; Santos, Irene; Zarour, Ahmad; Bonci, Eduard-Alexandru; Negoi, Ionut; Efetov, Sergey; Kochetkov, Viktor; Litvin, Andrey; Ingabire, Jc Allen; Bucyibaruta, Georges; Faustin, Ntirenganya; Habumuremyi, Sosthene; Imanishimwe, Alphonsine; de Dieu, Haragirimana Jean; Munyaneza, Emmanuel; Ncogoza, Isaie; Alameer, Ehab; Ndong, Abdourahmane; Radenkovic, Dejan; Chew, Min Hoe; Koh, Frederick; Ngu, James; Panyko, Arpad; Bele, Uros; Kosir, Jurij Ales; Daoud, Hassan; Blanco-Colino, Ruth; Minaya Bravo, Ana Maria; Jayarajah, Umesh; Wickramasinghe, Dakshitha; Adam, Mohammed Elmujtba Adam Essa; Rutegard, Martin; Sund, Malin; Adamina, Michel; Gialamas, Eleftherios; Horisberger, Karoline; Alshaar, Muhammad; Huang, Abel; Lohsiriwat, Varut; Charles, Shane; Jlassi, Haithem; Isik, Arda; Leventoglu, Sezai; Lekuya, Herve Monka; Lule, Herman; Kopetskyi, Slava; Alsaadi, Hayder; Alshryda, Sattar; Alser, Osaid; Bankhead-Kendall, Brittany; Breen, Kerry; Kaafarani, Haytham; Mashbari, Hassan; Cal, Fernando Bonilla; Al-Naggar, Hamza; Maimbo, Mayaba; Mazingi, Dennis; Abbott, Tom; Adamina, Michel; Akhbari, Melika; Benson, Ruth; Bhanderi, Shivam; Biccard, Bruce; Caruana, Edward; Chakrabortee, Sohini; Chapatwala, Reema; Costas-Chavarri, Ainhoa; Demetriades, Andreas K.; Desai, Anant; Di Saverio, Salomone; Drake, Thomas; Edwards, John; Evans, Jonathan; Fiore, Marco; Ford, Samuel; Fotopoulou, Christina; Fowler, Alexander; Futaba, Kaori; Ganly, Ian; James, Harelimana Grace; Griffiths, Ewen; Gronchi, Alessandro; Hutchinson, Peter; Hyman, Gabriella Yael; Incorvia, Joseph; Jain, Ritu; Jenkinson, Michael; Khan, Tabassum; Knight, Stephen Richard; Kolias, Angelos; Kudsk-Iversen, Soren; Kwan, Tsun Yu; Leung, Elaine; Mayol, Julio; McKay, Siobhan; Meara, John G.; Mills, Emily; Moug, Susan; Patel, Akshay; Perinotti, Roberto; Rice, Henry E.; Roberts, Keith; Schache, Andrew; Shaw, Richard; Smart, Neil; Stephens, Matthew; Stewart, Grant D.; Teasdale, Ella; Vaughan-Shaw, Peter; Vidya, Raghavan; Wright, Naomi; Wuraola, Funmilola; Zimmelman, Natalie; Agastra, Ervis; Thereska, Dariel; Martin Lucchini, Sergio; Laudani, Veronica; Boccalatte, Luis; Chwat, Carina; Pedraza Salazar, Ivana Ines; Pantoja Pachajoa, Diana Alejandra; Duro, Agustin; Calderon Arancibia, Jose Alfredo; Cox, Daniel; D'Aulerio, Giuliana; Dudi-Venkata, Nagendra; Egoroff, Natasha; Farik, Shebani; Lott, Natalie; Moss, Jana-Lee; Pockney, Peter; Rennie, Sarah; Tan, Lorwai; Varghese, Christopher; Vo, Uyen Giao; Watson, David; Watters, David; Wright, Deborah; Bright, Tim; Hollington, Paul; Zhou, Xuanyu; Kroon, Hidde M.; Farfus, Anthony; Barker, John; Watson, Eleanor; Stevens, Sean; Latif, Haider; Dawson, Amanda Caroline; Chuan, Alwin; Muralidharan, Vijayaragavan; Wong, Enoch; Ackermann, Travis; Pacilli, Maurizio; Hodgson, Russell; Heriot, Alexander; Choong, Peter; Brown, Wendy; Lidder, Surjit; Yeung, Justin; Traeger, Luke; Regalo, Guillermo; Gourlay, Ralph; Pockney, Peter; Badiani, Sarit; Koh, Cherry; Putnis, Soni; Dawson, Amanda Caroline; Haider, Fayza; Mitul, Ashrarur Rahman; Komen, Niels; Dhondt, Bert; Cappeliez, Serge; Pigeolet, Manon; van Ramshorst, Gabrielle; Schoneveld, Martijn; Stijns, Jasper; Oosterlinck, Wouter; Flamey, Nicolas; Kpangon, Cyrille; Agbadebo, Mouhamed; Tobome, Semevo Romaric; Cerovac, Anis; Barros, Aldo Vieira; Aguiar Junior, Samuel; Baiocchi, Glauco; do Amaral Campos, Heloisa Galvao; Gross, Jefferson; Fernandez Coimbra, Felipe Jose; Kowalski, Luiz Paulo; Makdissi, Fabiana; Nakagawa, Suely; Duprat Neto, Joao Pedreira; Vartanian, Jose Guilherme; Yazbek, Guilherme; Zequi, Stenio C.; Flumignan, Ronald; Slavchev, Mihail; Jaworska, Natalia; Dell, Angela; Shanthanna, Harsha; Martin, Janet; Behzadi, Abdollah; Nessim, Carolyn; Mozel, Michelle; St-germain, Pascal; Russell, Crispin; Groot, Gary; Safieddine, Najib; Wijeysundera, Duminda; Eskander, Antoine; Chadi, Sami; MacKenzie, Shawn; Flexman, Alana; Heredia, Fernando; Marta Modolo, Maria; Villanueva, Julio; Waissbluth, Sofia; Macchiavello, Roberto; Escudero, Mario I.; Fuentes, Tyare; Mimica, Ximena; Olivos, Maricarmen; Bolivar Saenz, Dinimo; Caicedo, Lina; Pablo Alzate, Juan; Luna, Joaquin; Pedraza Alonso, Nestor Fabian; Ortiz Silva, Camilo; Rodriguez, Juliana; Silva-Igua, Liliana; Torres, Martha Luz; Maria Trujillo, Lina; Nieto Calvache, Albaro Jose; Balanta-Melo, Julian; Figueroa-Casanova, Rafael; Garcia-Montoya, Oscar-Julian; Marulanda Toro, Carlos Andres; Velez Botero, Marcela; Mendoza Arango, Maria Clara; Diaz Martinez, Eneida; Gutierrez Perdomo, Valentina; Montenegro, Emileth; Mihanovic, Jakov; Aviles Jimenez, Pablo Mijahil; Gouvas, Nikolaos; Novysedlak, Rene; Rodriguez-Abreu, Julia; Mejia, Dolores; Lincango-Naranjo, Eddy; Abouelnagah, Galal; Shehata, Sameh; Rida, Ahmed Hossam Eldin Fouad; Hassan, Ramy A.; Saad, Mahmoud M.; Loaloa, Mohamed Reda; Mostafa, Badr; Qassem, Mohamed; Fahmy, Mohamed; Abozied, Hesham; Azzam, Ahmed Y.; Ghozy, Sherief; Sallam, Asser; Shehta, Ahmed; Emile, Sameh; Abdelkhalek, Mohamed; Samaka, Rehab; Morsy, Amr; Sherif, Ahmed Elshawadfy; Negussie, Abraham; Fisseha, Tigist; Shumbash, Kibruyisfaw; Abebe, Metasebia; Hailu, Samuel; Yasin, Seid Mohammed; Akililu, Yemisirach Bizuneh; Megersa, Abebe; Tefera, Teshome; Assefa, Melatework; Atnafu, Bahru; Tsegaye, Bereket; Bezabih, Yoseph Solomon; Sisay, Silamlak; Bekele, Kebebe; Jira, Moa; Mengesha, Mengistu G.; Derilo, Habtamu; Degefa, Eyueal; Tadesse, Anteneh; Nidaw, Melkamu; Sarjanoja, Elise; Kauppila, Joonas H.; Testelin, Sylvie; Boucher, Sophie; Jouffret, Lionel; Lakkis, Zaher; Le Bian, Alban Zarzavadjian; Harper, Luke; des Deserts, Marc Danguy; Andre, Benoit; Slim, Karem; Verhaeghe, Romain; Police, Andrea; Girard, Edouard; Chebaro, Alexandre; Nkembi, Armande Subayi; Arnalsteen, Laurent; Ballouhey, Quentin; Mege, Diane; Jeandel, Clement; Duchalais, Emilie; Bouche, Pierre-Alban; Manceau, Gilles; Cretolle, Celia; Hervieux, Erik; Girard, Noemie; Seguin-Givelet, Agathe; Gaujoux, Sebastien; De Simone, Belinda; Boisson, Matthieu; Bergeat, Damien; Arnaud, Alexis P.; Fredon, Fabien; Nappi, Francesco; Kassir, Radwan; Scalabre, Aurelien; Migliorelli, Federico; Verhaeghe, Romain; Ezanno, Anne-Cecile; Seeliger, Barbara; Vaysse, Charlotte; Charbonneau, Helene; Misrai, Vincent; Abbo, Olivier; Angeles, Martina Aida; Brunaud, Laurent; Demetrashvili, Zaza; Modabber, Ali; Wolf, Sebastian; Kamphues, Carsten; Hoehn, Philipp; Glowka, Tim R.; Rokohl, Alexander Christopher; Bork, Ulrich; Fluegen, Georg; Horch, Raymund E.; Schmedding, Andrea; Schnitzbauer, Andreas; Eberbach, Helge; Schlager, Daniel; Spelsberg, Fritz; Keppler, Lena; Hecker, Andreas; Wolfer, Susanne; Ronellenfitsch, Ulrich; Nitschke, Christine; Peiper, Christian; Hakami, Ibrahim; Welter, Stefan; Nikolaieva, Karine; Roth, Andreas; Lindert, Judith; Gousias, Konstantinos; Rissmann, Anke; Linz, Valerie Catherine; Rahbari, Nuh; Rassweiler-Seyfried, Marie-Claire; Gut, Anna Eleonora; Gempt, Jens; Reim, Daniel; Wagner, Arthur; Albertsmeier, Markus; Keppler, Alexander M.; Stoleriu, Mircea Gabriel; Saier, Tim; Stadler, Josef; Kaiser, Julia Christina; Brunner, Stefan M.; Pfister, Karin; Herzberg, Jonas; Nowak, Kai; Reinhard, Tobias; Stavrou, Gregor A.; Koenigsrainer, Alfred; Konrads, Christian; Quante, Markus; Laban, Simon; von Pusch, Silke; Hirschburger, Markus; Doerner, Johannes; Wiegering, Armin; Tampaki, Ekaterini Christina; Gutierrez Ruiz, Alitza; Rodas, Alejandra; Lucia Portilla, Ana; Recinos, Gustavo; Aguilera-Arevalo, Maria-Lorena; Carrera, Jacqueline; Duarte, Amalia Barrios; Lowey, Megan; Barillas, Sabrina; Suroy, Atul; Vaishnav, Dhaivat; Chowdappa, Raghunandan Gorantlu; Madabhavi, Irappa; Bhat, Dhananjaya; Venkatappa, Sunil Kumar; Thakar, Sumit; Jain, Kavitha; Kumar, Aruna; Nagar, Manoj; Mishra, Tushar; Sekar, Arunkumar; Gupta, Anand; Kaman, Lileswar; Karthigeyan, Madhivanan; Tripathi, Manjul; Rammohan, Ashwin; Vayoth, Sudheer Othiyil; Rajanbabu, Anupama; Subbian, Anbukkani; Gupta, Rahul; Raut, Monish; Evelyn R, Nissi; Kannaiyan, Lavanya; Matai, Anil; Misra, Sanjeev; Bhende, Vishal; Muthu, Sathish; Ghosh, Indranil; Sharma, Abhishek; Bajaj, Ankur; Rajan, Shiv; Agarwal, Gaurav; Pawar, Pranay; Alexander, Philip; Vijayakumar, M. Vijayakumar; Hameed, B. M. Zeeshan; Badareesh, L.; Chaudhry, Navneet Kumar; Baliarsing, Lipika; Dharap, Satish; Kulkarni, Amruta; Thyavihally, Yuvaraja; Sharma, Rahul Deo; Pramesh, C. S.; Soni, Rajesh; Dube, Surya Kumar; Sharma, Shilpa; Singh, Harvinder; Bains, Lovenish; Ghodke, Rahul; Kumar, Ashwani; Sodhai, Vivek; Maji, Suvendu; Basu, Somprakas; Mahakalkar, Chandrashekhar; Kannan, Ravi; Mehraj, Asif; Ranganath, N.; Phadnis, Ashish; Yadev, I.; Kavalaka, Alfie; Mittal, Rohin; Vallam, Karthik Chandra; Akhavizadegan, Hamed; Maleki, Esmaeil Rezghi; Kandevani, Naser Yousefzadeh; Ikele, Hilary; McNestry, Catherine; Fleming, Christina; O'Brien, Stephen; Abd Elwahab, Sami; Davis, Niall; Javadpour, Mohsen; McDonnell, Brendan; Connor, Clare O.; Bolger, Jarlath; Clancy, Cillian; Croghan, Stefanie M.; Donlon, Noel; Cullinane, Carolyn; Creavin, Ben; Muheilan, Muheilan; Earley, Helen; Kabir, Syed Mohammad Umar; Fahadullah, Muhammad; Ryan, Eanna; Connelly, Tara; Zmora, Oded; Hashimoto, Daisuke; Alqudah, Majdi Ali; Alajalen, Amer; Omari, Rand Y.; Ayasra, Faris; Qasem, Abdulrahman; Alawneh, Yazan; Ahmad, Amer; Aladawi, Omar; Alrayes, Bourhan; Haidar, Hanan; Husain, Shatha; Qassem, Faisal; Sumadi, Adnan; Abu Salhiyeh, Ala'a; Al-Manaseer, Balqees Mahmoud; Alsunna, Zaid; Ra'ed, Hazim; Hamad, Faten Reyad Bani; Abuleil, Amro; Abou Chaar, Mohamad K.; Jimaale, Elmi Ahmed Mohamed; Abu-Mehsen, Marah; Olaywah, Noor; Wafi, Omar; Ababneh, Hazim; Abu-Ismail, Luai; Khamees, Almu'atasim; Alkhatib, Ahmad; Bolatbekova, Raikhan; Kulimbet, Mukhtar; Nurgozhin, Talgat; Saliev, Timur; Zhussupov, Baurzhan; Almabayev, Ydyrys; Fakhradiyev, Ildar; Saliev, Timur; Kaidarova, Dilyara; Tamoos, Khalil; Aqeelah, Ahmed; Mohammed, Alsnosy Abdullah Khalefa; Al Maadany, Faraj; Alkadeeki, Ghadah; Gahwagi, Milad; Aldressi, Wafa; Amnaina, Mohamed; Alansari, Arowa Hassan Abdulrahman; Alkaseek, Akram; Yagoub, Ghozlan; Ben Amer, Anass; Salem, Marwa; Almugaddami, Ayman; Burgan, Dania; Abdelkabir, Mohammed; Alshareef, Khayriyah; Ben Jouira, Rayet al Islam; Meelad, Ayman; Bouhuwaish, Ahmad; Dwaga, Sumayya Essayah; Khalifa, Houda; Almiqlash, Bushray; Suliaman, Taha; Alawami, Mohammed; Elhajdawe, Fras; Aboazamazem, Hajir; Ellojli, Ibrahim; Msherghi, Ahmed; Saleh, Ismail Ali; Alayan, Mohammed; Roslani, April Camilla; Ndayishyigikiye, Marcel Didier; Munyika, Akutu; Plarre, Philipp; Borowski, David W.; Nashidengo, Pueya Rashid; Noltes, Milou; Steinkamp, Pieter; Wells, Cameron; Teague, Rebecca; Elliott, Brodie; Kieser, David; Mohyieldin, Omar; Varghese, Chris; McIntosh, Nick; Haran, Cheyaanthan; Rennie, Sarah; King, Jasmin; Ha, Jeong; McGuinness, Matthew James; Adesanya, Opeoluwa; Olaogun, Julius; Akinmade, Akinola; Bwala, Kefas; Agbonrofo, Peter; Afolabi, Akinwale; Usang, Usang; Ekenze, Sebastian; Olori, Samson; Lawal, Taiwo Akeem; Seyi-Olajide, Justina; Okunlola, Abiodun; Ekiti, Ido; Williams, Omolara; Adisa, Adewale; Abdur-Rahman, Lukman; Kache, Stephen; Sale, Danjuma; Anyanwu, Lofty-John; Okereke, Chukwuma; Tolani, Musliu Adetola; Filipce, Venko; Todorovic, Lazar; Pejkova, Sofija; Stavridis, Sotir; Massoud, John George; Alsibai, Sareyah; Sultan, Rizwan; Altaf, Humera Naz; Bhatti, Abu Bakar Hafeez; Waqar, Shahzad Hussain; Aziz, Aliya; Kerawala, Asad Ali; Rai, Lajpat; Anwer, Mariyah; Tariq, Aiman; Ayub, Bushra; Niazi, Sami Ullah; Naseem, Muhammad Yasir; Sarwar, Muhammad Zeeshan; Khokhar, Muhammad Imran; Zahid, Imdad Ahmad; Majid, Haroon Javaid; Talat, Nabila; Asif, Muhammad; Chaudhary, Muhammad Hamid; Farooq, Umer; Ahmad, Siddique; Mabood, Waleed; Bukhari, Syed Imran; Tariq, Muhammad; Yaqoob, Eesha; Javed, Saad; Malik, Muhammad Usman; Yaqoob, Hassan Nawaz; Cukier, Moises; Falcon Pacheco, Glenda Marina; Mas Melendez, Robinson; Paucar Urbina, Arazzelly Del Pilar; Rios Chiuyari, Jose; Otiniano Alvarado, Carlos Eduardo; Rivera Lau, Lorena Fuentes; Borda-Luque, Giuliano; Niquen-Jimenez, Milagros; Arias, Claudia; Zegarra, Sergio; Betalleluz Pallardel, Jenner; Ugarte Oscco, Regina Amparo; Mendiola, Gian; Carpio Colmenares, Yahaira Tatiana; Zapata, Carlos Shiraishi; Rosa Ortiz, Maria; Dione Sacdalan, Marie; Major, Piotr; Borges, Filipe Castro; Viveiros, Octavio; Serralheiro, Pedro; Santos-Costa, Paulo; Mendes, Filipa; Melo, Miguel Rocha; Cardoso, Paulo; Soares, Ana; Azevedo, Jose; Pereira, Rita Goncalves; Silva, Nelson; Caiado, Andre; Sacras, Maria Luis; Azevedo, Pedro; Almeida-Reis, Rui; Cunha, Miguel F.; Oliveira, Joao; Nogueiro, Jorge; Sampaio-Alves, Mafalda; Costa, Luciana Cidade; Baia, Catarina; Deus, Ana Claudia; Branquinho, Rita; Marcal, Andre; Tojal, Andre; Zarour, Ahmad; Makkai-Popa, Silviu Tiberiu; Mironescu, Aurel; Grama, Florin; Toma, Elena Adelina; Negoi, Ionut; Filipescu, Daniela; Bacalbasa, Nicolae; Motas, Natalia; Ionescu, Sebastian; Ginghina, Octav; Costea, Radu; Zarnescu, Narcis Octavian; Drasovean, Radu; Bonci, Eduard-Alexandru; Dimofte, Mihail-Gabriel; Porumb, Vlad; Kirov, Mikhail; Molitvin, Yegor; Litvin, Andrey; Pykhteev, Vadim; Raevskaya, Marianna; Efetov, Sergey; Butyrskii, Aleksandr; Alshahrani, Mushabab; Althumairi, Azah; Alzerwi, Nasser; Al Ameer, Ahmed; Madkhali, Tariq; Almulhim, Abddulrahman Saleh; Ghazwani, Salman; Ayoub, Abdu; Iskander, Othman; Ghunaim, Mohammed; Alharthi, Mohammed; Alzaidi, Turki M.; Althumairi, Azah; Alyami, Mohammad; Al Amri, Abdulrahman; Althumairi, Azah; AlFakhri, Abdullah; Alhefdhi, Amal; Chowdhury, Sharfuddin; Nouh, Thamer; Alshehri, Ameen; Alzahrani, Abdulrahman; Alalawi, Yousef; Awad, Selmy; Konate, Ibrahima; Ndong, Abdourahmane; Tendeng, Jacques; Teo, Nan Zun; Koh, Frederick; Kosir, Jurij Ales; Bele, Uros; Aqil, Sabra; Barrena Lopez, Cristina; Sanchez Mozo, Ana; Rodriguez Infante, Antonio; Caja Vivancos, Patricia; Prieto, Mikel; Alberdi San Roman, Igor; Gomez Fernandez, Laura; Munoz Vives, Josep Maria; Carreras-Castaner, Anna; Diaz-Feijoo, Berta; Sieira-Gil, Ramon; Turrado-Rodriguez, Victor; Sanchez Lopez, Anna; Sanchez-Cabus, Santiago; Jimenez Toscano, Marta; Canals Sin, Ma Pilar; Garcia Laura, Saura; Martin Sole, Oriol; Palazon Bellver, Pedro; Perez-Bertolez, Sonia; Prat-Ortells, Jordi; Riba Martinez, Mireia; Rubio-Palau, Josep; Tarrado, Xavier; Nunez, Jorge; Alonso Mendoza, Veronica; Bescos, Coro; Espin-Basany, Eloy; Espinosa-Bravo, Martin; Gil-Sala, Daniel; Gonzalez-Suarez, Susana; Montferrer Estruch, Nuria; Porteiro Marino, Lucia; Rodriguez-Tesouro, Ana; Rojas Portilla, Fabian; Tormos Perez, M. Pilar; Vives, Inmaculada; Garcia De Cortazar, Unai; Tudela, Kiara; Landaluce-Olavarria, Aitor; Estaire Gomez, Mercedes; Almoguera, Jorge; Ugarte-Sierra, Bakarne; Jimenez, Virginia; Bertrand, Marta; Cardenas Puiggros, Laura; Delisau-Puig, Olga; Garcia-Adamez, Jorge; Julia Bergkvist, David; Maldonado-Marcos, Eloy; Diego Garcia, Lucia; Roldon Golet, Marta; Soto-Darias, Ivan; Cristina Rahy-Martin, Aida; Enjuto, Diego; Ramos-Luengo, Adolfo; Delgado Fernandez, Juan; Lugo Duarte, Carolina; Ojeda Thies, Cristina; Marquez, Lucila; Crego Vita, Diana; Dziakova, Jana; Minaya Bravo, Ana Maria; Canno Velasco, Jorge; Mateo-Sierra, Olga; Quintana-Villamandos, Begona; Rey Valcarcel, Cristina; Rio, Javier; Roman Garcia de Leon, Laura; Di Martino, Marcello; Prada, Jorge; Serrano Gonzalez, Javier; Losada, Manuel; Castell Gomez, Jose Tomas; Corripio-Sanchez, Ramon; Forero-Torres, Alexander; Manuel Morales-Puebla, Jose; Perez-Chrzanowska, Hanna; Valderrabano Gonzalez, Santiago; Yebes, Alvaro; Zapardiel, Ignacio; Diez Alonso, Manuel; Morales Palacios, Nelson; Cabanero Sanchez, Alberto; Sanchez Fernandez, Fatima; Abad Gurumeta, Alfredo; Abad-Motos, Ane; Corella, Fernando; Ripolles-Melchor, Javier; Sanz-Gonzalez, Rosa; Alcaraz Fuentes, Marta; Fernandez Martin, Maria Teresa; Calvo Espino, Pablo; Carrasco Prats, Milagros; Fernandez-Lopez, Antonio-Jose; Garcia Escudero, Damian; Garcia Soria, Vanesa; Martinez Alonso, Jesus Aaron; Ruiz-Marin, Miguel; Gomez Perez, Beatriz; Moya-Angeler, Joaquin; Fernandez Martinez, Daniel; Llaquet Bayo, Heura; Colas-Ruiz, Enrique; Bella Romera, Susana; Gavalda Pellice, M. Teresa; Jorda Sole, Misericordia; Ruiz Velasquez, Enrique Jose; Nunez, Bernardo; Jimenez, Raul; Zabaleta, Jon; Jose Gonzalez-Gimeno, Maria; Ortega Vazquez, Irene; Perez Ferrer, Antonio; Martin-Laez, Ruben; Moreno Suarez, Marcelo; Freiria Eiras, Miguel Angel; Ramallo-Solis, Irene; Gomez-Rosado, Juan-Carlos; Oliver Guillen, Jose Ramon; Achalandabaso Boira, Mar; Catala Bauset, Juan Carlos; Domenech, Julio; Badenes, Rafael; Carlos Bernal-Sprekelsen, Juan; Sancho-Muriel, Jorge; De Andres-Asenjo, Beatriz; Tejero-Pintor, Francisco J.; Vallve-Bernal, Marc; Vazquez Melero, Alba; Das, Andre; Ganapathy, Thanga; Gunarasa, Yohesuwary; Mariapan, Kalyani; Muniandy, Maathichsudhaar; Osman, Mohd Firdauss; Azmi, Mohd Azem Fathi Mohammad; Soh, Jien Yen; Zain, Wan Zainira Wan; Zakaria, Andee Dzulkarnaen; Zakaria, Zaidi; Chan, Kheng Hooi; Hayati, Firdaus; Johan, Syamim; Mah, Jin Jiun; Sriram, Ratha Krishnan; Subramaniam, Sentilnathan; Shahimi, Nur Shahirah Binti Muhammad; Hamdan, Khairul Hazim; Ibrahim, Mohd Razali; Muthkumaran, Guhan; Tan, Ju Ann; Thanapal, Mohana Raj; Aziz, Dayang Anita Abdul; Bastion, Mae-Lynn; Harun, Mohd Hairul Nizam; Imran, Farrah-Hani; Din, Norshamsiah Md; Zain, Ayesha Mohd; Mustapha, Mushawiahti; Nabil, Syed; Naffi, Ainal Adlin; Nazimi, Abd Jabar; Ramli, Roszalina; Soon, Bee Hong; Bal, Pavin; Cheng, Joo Qing; Draman, Mohd Rusdi; Fadzli, Ahmad Nazran; Ghauth, Sakina; Hung, WeiPin; Jamaris, Suniza; Koh, Peng Soon; Krishnasamy, Sivakumar; Lee, Yeong Sing; Liew, Yew Toong; Lim, Jeffery Zk; Lim, Raymond Chung Siang; Lim, Hiong Chin; Pauzi, Siti Farhan Moh; Nah, Shireen Anne; Nair, Ashvin Krishna; Ng, Doris Sin Wen; Yong, Yuki Julius Ng We; Ramayah, Kamarajan; Roslani, April Camilla; Saaid, Rahmah; Sanmugam, Anand; See, Mee Hoong; Seevalingam, Kanesh Kumaran; Sethi, Neha; Singaravel, Srihari; Ganapathy, Thanga; Gunarasa, Yohesuwary; Mariapan, Kalyani; Muniandy, Maathichsudhaar; Osman, Mohd Firdauss; Azmi, Mohd Azem Fathi Mohammad; Soh, Jien Yen; Zain, Wan Zainira Wan; Zakaria, Andee Dzulkarnaen; Zakaria, Zaidi; Chan, Kheng Hooi; Hayati, Firdaus; Johan, Syamim; Mah, Jin Jiun; Sriram, Ratha Krishnan; Subramaniam, Sentilnathan; Zaidi, Syeda Nureena Syed Jafer Hussain; Tang, Chu Yik; Teoh, Li Ying; Wong, Kian Boon; Xavier, Ruben; Yahaya, Ahmad Shuib; Consorti, Giuseppe; Balercia, Paolo; Catarzi, Lisa; Di Bartolomeo, Mattia; Chitul, Andrei
    We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre-defined sub-group analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26,948 (27.9%) patients isolated before surgery. Postoperative pulmonary complications were recorded in 1947 (2.0%) patients of which 227 (11.7%) were associated with SARS-CoV-2 infection. Patients who isolated pre-operatively were older, had more respiratory comorbidities and were more commonly from areas of high SARS-CoV-2 incidence and high-income countries. Although the overall rates of postoperative pulmonary complications were similar in those that isolated and those that did not (2.1% vs 2.0%, respectively), isolation was associated with higher rates of postoperative pulmonary complications after adjustment (adjusted OR 1.20, 95%CI 1.05-1.36, p = 0.005). Sensitivity analyses revealed no further differences when patients were categorised by: pre-operative testing; use of COVID-19-free pathways; or community SARS-CoV-2 prevalence. The rate of postoperative pulmonary complications increased with periods of isolation longer than 3 days, with an OR (95%CI) at 4-7 days or >= 8 days of 1.25 (1.04-1.48), p = 0.015 and 1.31 (1.11-1.55), p = 0.001, respectively. Isolation before elective surgery might be associated with a small but clinically important increased risk of postoperative pulmonary complications. Longer periods of isolation showed no reduction in the risk of postoperative pulmonary complications. These findings have significant implications for global provision of elective surgical care.
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    Long term platinum-induced ototoxicity in pediatric patients
    (2018) Waissbluth, Sofia; Chuang, Angela; Del Valle, Alvaro; Cordova, Marcela
    Objectives: Platinum-based chemotherapy treatments are effective against a variety of pediatric malignancies. However, its use can lead to permanent hearing loss. The aim of this study was to evaluate the long-term effect of platinum chemotherapy on hearing and evaluate its progression.
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    MATE1 expression in the cochlea and its potential involvement in cisplatin cellular uptake and ototoxicity
    (2023) Waissbluth, Sofia; Martinez, Agustin D.; Figueroa-Cares, Cindel; Sanchez, Helmuth A.; Maass, Juan C.
    BackgroundCisplatin appears to enter the cochlear cells through the organic cation transporter 2 (OCT2). There is recent evidence that multidrug and toxin extrusion protein 1 (MATE1) is involved in cisplatin-induced nephrotoxicity. Its presence and role in the ear are unknown.Aims/ObjectivesEvaluate the presence and localization of MATE1, and determine the localization of OCT2, in the cochlea. Evaluate cisplatin uptake with regard to MATE1 and OCT2 expression.Material and MethodsMurine cochlear explants and paraffin-embedded cochleae were evaluated with immunohistochemistry for OCT2 and MATE1. Explant cultures were also treated with Texas Red cisplatin to determine their cellular uptake.ResultsMATE1 is present in the cochlea. Most intense labeling of MATE1 and OCT2 was seen in the outer hair cells (OHCs) and pillar cells, respectively. Both transporters were observed in the spiral ganglion neurons and stria vascularis. Expression levels of OCT2 and MATE1 decreased following cisplatin exposure. Texas Red cisplatin staining was strong in OHCs and pillar cells.Conclusions and SignificanceTo the best of our knowledge, this is the first study demonstrating the presence and localization of MATE1 in the cochlea. OCT2 labeling was seen in pillar cells. Consistently, OHCs and pillar cells uptake Texas Red cisplatin.
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    Observed Frequency and Characteristics of Hearing Loss in Osteogenesis Imperfecta
    (2020) Waissbluth, Sofia; Lira, Karina; Aracena, Karina; Oyarzun, Javier; Willson, Matias; Seiltgens, Cristian
    Background: Osteogenesis imperfecta (OI) is a rare group of genetic disorders affecting connective tissue, with consequent bone fragility, frequent fractures and skeletal deformity. Depending on the type, patients can have blue sclera, dentinogenesis imperfecta, and hearing loss. Aim: To determine the frequency, type and audiometric characteristics of hearing loss in a group of patients with OI. Material and Methods: A prospective cohort study was completed. A clinical and diagnostic hearing evaluation with tympanometry, acoustic stapedial reflex, pure-tone and speech audiometry were performed. Results: Thirty patients completed the study; mean age of 22 years (range 6-63 years). Sixty seven percent had a type I OI. Overall, nine (30%) patients had hearing loss (15/60 ears). Of these, six had bilateral hearing loss. Of the 15 affected ears, six showed conductive hearing loss, five sensorineural hearing loss, and four mixed hearing loss. Patients with hearing loss were older than patients with normal hearing. Only one pediatric patient developed hearing loss. Of the ears without hearing loss, 13% did not have an acoustic stapedial reflex. Conclusions: In this group of patients with OI, 30% had hearing loss and among those ears with normal hearing, 13% did not have an acoustic stapedial reflex. Patients with OI should be monitored for hearing loss.
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    Sudden sensorineural hearing loss: Recovery rates according to audiometric patterns
    (2022) Waissbluth, Sofia; Sepulveda, Valeria; Urzua, Pablo
    Purpose: The aim of this study was to evaluate the different audiometric patterns in sudden sensorineural hearing loss (SSNHL), assess recovery rates based on the initial pattern and also, analyse the impact on speech discrimination scores (SDS).
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    The impact of COVID-19 preventive lockdowns on the prevalence of benign paroxysmal positional vertigo
    (2021) Waissbluth, Sofia; Garcia-Huidobro, Francisco; Araya-Cespedes, Macarena
    Introduction