Browsing by Author "Zamorano, Alejandra"

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    Benefits of home-based administration of palivizumab in high-risk groups
    (2024) Ortiz, Carolina; Vasquez, Ignacia; Zamorano, Alejandra; D'Apremont, Ivonne; Pittaluga, Enrica; Diaz, Marcela; Campos, Catalina
    Palivizumab, a humanized monoclonal antibody against the respiratory syncytial virus (RSV), rrently is indicated in groups at higher risk of developing severe RSV disease, such as extreme premature infants and patients with hemodynamically significant heart disease. In Chile, this strategy guaranteed by Law 20850 (Ricarte Soto Law). Nevertheless, barriers to its administration included the need to transfer these labile patients and exposure to other users, with the risk of contagion waiting rooms. Objective: to describe the impact of the palivizumab administration strategy in home care program for high-risk patients. Patients and Method: retrospective, descriptive, observational cohort study of patients born before 32 weeks of gestation or weighing less than 1500 grams, who received palivizumab between January 2019 and December 2021 at the Hospital Dr. S & oacute;tero Rio. . Results: 272 patients were included (median gestational age: 30 weeks). The percentage of doses administered at home was 35.9% (2019) and 37.2% (2021). Each dose of 2020 following the administration in Neonatology, was administered at home during the COVID-19 pandemic. The median interval between doses was as recommended. Adherence was over 90%. The unadjusted incidence RSV infection was 5.7% (2019), 0% (2020), and 0.9% (2021). Conclusions: palivizumab administration was adequate and timely; home indication was associated with high adherence rates and administration interval between doses in line with current recommendations.
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    Effectiveness of Asthma Education with and Without a Self-Management Plan in Hospitalized Children
    (TAYLOR & FRANCIS LTD, 2009) Espinoza Palma, Tatiana; Zamorano, Alejandra; Arancibia, Francisca; Bustos, Maria Francisca; Jose Silva, Maria; Cardenas, Consuelo; De La Barra, Pedro; Puente, Victoria; Cerda, Jaime; Castro Rodriguez, Jose A.; Prado, Francisco
    Background. Formal education in primary care can reduce asthma exacerbations. However, there are few studies in hospitalized children, with none originating in Latin America. Methods. A prospective randomized study was designed to evaluate whether a full education with self-management plan (ESM) was more effective than an education without self-management plan (E) in reducing asthma hospitalization. Children (5 to 15 years of age) who were hospitalized for an asthma attack were divided in two groups. Children in the E group received general instructions based on a booklet. Those in the ESM group received the same booklet plus a self-management guide and a puzzle game that reinforces the lessons learned in the booklet. Patients were interviewed every 3 months, by telephone, for one year. Interviewers recording the number of hospitalizations, exacerbations, and emergency visits for asthma and oral steroid burst uses. Results. From 88 children who met the inclusion criteria, 77 (86%) completed one year of follow-up (41 from E and 36 from ESM group). Overall, after one year, the hospitalization decreased by 66% and the inhaled corticosteroids therapy increased from 36% to 79%. At the end of the study, there was no difference in exacerbations, emergency visits, oral steroid burst uses, or hospitalizations between the two groups. Conclusions. Asthma education with or without a self-management plan during asthma hospitalization were effective in reducing exacerbations, emergency visits, oral steroid burst uses, and future rehospitalizations. This evidence supports the importance of providing a complete asthma education plan in any patient who is admitted for asthma exacerbation.