Browsing by Author "Zhang, Yuan"

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    American Society of Hematology 2020 guidelines for management of venous thromboembolism: treatment of deep vein thrombosis and pulmonary embolism
    (2020) Ortel, Thomas L.; Neumann, Ignacio; Ageno, Walter; Beyth, Rebecca; Clark, Nathan P.; Cuker, Adam; Hutten, Barbara A.; Jaff, Michael R.; Manja, Veena; Schulman, Sam; Thurston, Caitlin; Vedantham, Suresh; Verhamme, Peter; Witt, Daniel M.; Florez, Ivan D.; Izcovich, Ariel; Nieuwlaat, Robby; Ross, Stephanie; Schunemann, Holger J.; Wiercioch, Wojtek; Zhang, Yuan; Zhang, Yuqing
    Background: Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), occurs in; 1 to 2 individuals per 1000 each year, corresponding to;300 000 to 600 000 events in the United States annually.
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    Methodology for adaptation of the ASH Guidelines for Management of Venous Thromboembolism for the Latin American context
    (2021) Neumann, Ignacio; Izcovich, Ariel; Alexander, Kendall E.; Castano, Jenny; Plovnick, Robert; Kunkle, Robert; Zhang, Yuan; Aguilar, Ricardo; Leon Basantes, Guillermo; Casais, Patricia; Colorio, Cecilia C.; Guillermo Esposito, Maria Cecilia; Garcia Lazaro, Pedro P.; Pereira, Jaime; Meillon-Garcia, Luis A.; Rezende, Suely Meireles; Carlos Serrano, Juan; Tejerina Valle, Mario L.; Schuenemann, Holger
    Background: From 2017 to 2020, the American Society of Hematology (ASH) collaborated with 12 hematology societies in Latin America to adapt the ASH guidelines on venous thromboembolism (VTE).
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    New methods facilitated the process of prioritizing questions and health outcomes in guideline development
    (2022) Wiercioch, Wojtek; Nieuwlaat, Robby; Zhang, Yuan; Alonso-Coello, Pablo; Dahm, Philipp; Iorio, Alfonso; Manja, Veena; Mustafa, Reem A.; Neumann, Ignacio; Ortel, Thomas L.; Rochwerg, Bram; Santesso, Nancy; Vesely, Sara K.; Akl, Elie A.; Schunemann, Holger J.
    Background: Health guideline development requires sequential prioritization of the guideline topic, questions, and health outcomes. In this paper we report on new approaches for prioritizing questions and outcomes in guidelines. Methods: Ten guideline panels on venous thromboembolism rated potential guideline questions on a 9-point scale according to their overall importance and 6 criteria: common in practice, uncertainty in practice, variation in practice, new evidence available, cost consequences, not previously addressed. We randomized panelists to rate one potential question with and without the 6 criteria. Panelists rated importance of outcomes, defined with health outcome descriptors (HODs), using a 9-point scale, and health utility of outcomes on a visual analogue scale. Results: Of 469 potential questions identified, 72.5% were rated as important but not of high priority, and 25.4% as high priority. Each criterion was significantly associated with the overall importance rating. The overall importance rating means were 5.96 (SD 2.38) and 6.53 (SD 2.45) ( P = 0.25) for those randomized to rate questions with and without the criteria, respectively. The mean importance rating for 121 outcomes was 6.01 (SD 1.25), with 35.5% rated as critical for decision-making. Panelists provided health utility ratings for 127 outcomes, with a minimum mean rating of 0.12 (SD 0.10) and maximum of 0.91 (SD 0.15). Conclusion: Our structured process provided information to help explain perspectives of question importance, to facilitate panels' outcome prioritization, and to facilitate decision-making in guideline development. (c) 2021 Published by Elsevier Inc.