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Browsing Colecciones Institucionales by browse.metadata.categoriaods "03 Salud y bienestar"
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- Item1,4-Dihydropyridines: Reactivity of nitrosoaryl and nitroaryl derivatives with alkylperoxyl radicals and ABTS radical cation(2004) Valenzuela, V.; Santander, P.; Camargo, C.; Squella, J.A.; López Alarcón, Camilo Ignacio; Nuñez Vergara, L.J.
- Item1-benzoyl-2-(2-nitrophenyl)-1H-benzimidazole derivatives: A novel approach to the development of new HIV-1 reverse transcriptase inhibitors(2007) Vásquez Velásquez, David; Lagos Arévalo, Carlos Fernando; Mella Raipán, Jaime Alberto; González Contreras, Luis Gerardo; Ebensperger González, Roberto Alejandro; Alvarez Figueroa, María Javiera; Sáez Moya, Edmundo Alfredo; Pessoa Mahana, Hernán; Araya Secchi, Raul; Gonzalez Wong, Angel; Perez-Acle, Tomas; Pessoa Mahana, Carlos David
- Item10-year experience in patients operated for acute invasive fungal rhinosinusitis(2020) Lagos, A.; Ferrada, S.; Muñoz, T.; Maul Fonseca, Ximena; Finkelstein, A.; González, C.; Fonseca Arrieta, María Ximena; Callejas Canepa, Claudio Andrés
- Item11 beta-Hydroxysteroid Dehydrogenase Type 1 is Overexpressed in Subcutaneous Adipose Tissue of Morbidly Obese Patients(SPRINGER, 2009) Munoz, Rodrigo; Carvajal, Cristian; Escalona, Alex; Boza, Camilo; Perez, Gustavo; Ibanez, Luis; Fardella, Carlos11 beta-Hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) enzyme catalyzes interconversion of inactive cortisone to active cortisol. Its expression in adipose tissue has been associated with obesity and some of its metabolic disorders. Controversies regarding which fat depots [subcutaneous adipose tissue (SAT) or visceral adipose tissue (VAT)] have higher expression still remain. The aim of this work was to evaluate 11 beta-HSD1 expression in SAT and VAT of obese patients and evaluate its association to metabolic features of metabolic syndrome.
- Item11 beta-hydroxysteroid dehydrogenase type-2 and type-1 (11 beta-HSD2 and 11 beta-HSD1) and 5 beta-reductase activities in the pathogenia of essential hypertension(HUMANA PRESS INC, 2010) Campino, Carmen; Carvajal, Cristian A.; Cornejo, Javiera; San Martin, Betty; Olivieri, Oliviero; Guidi, Giancesare; Faccini, Giovanni; Pasini, Francesco; Sateler, Javiera; Baudrand, Rene; Mosso, Lorena; Owen, Gareth I.; Kalergis, Alexis M.; Padilla, Oslando; Fardella, Carlos E.Cortisol availability is modulated by several enzymes: 11 beta-HSD2, which transforms cortisol (F) to cortisone (E) and 11 beta-HSD1 which predominantly converts inactive E to active F. Additionally, the A-ring reductases (5 alpha- and 5 beta-reductase) inactivate cortisol (together with 3 alpha-HSD) to tetrahydrometabolites: 5 alpha THF, 5 beta THF, and THE. The aim was to assess 11 beta-HSD2, 11 beta-HSD1, and 5 beta-reductase activity in hypertensive patients. Free urinary F, E, THF, and THE were measured by HPLC-MS/MS in 102 essential hypertensive patients and 18 normotensive controls. 11 beta-HSD2 enzyme activity was estimated by the F/E ratio, the activity of 11 beta-HSD1 in compare to 11 beta-HSD2 was inferred by the (5 alpha THF + 5 beta THF)/THE ratio and 5 beta-reductase activity assessed using the E/THE ratio. Activity was considered altered when respective ratios exceeded the maximum value observed in the normotensive controls. A 15.7% of patients presented high F/E ratio suggesting a deficit of 11 beta-HSD2 activity. Of the remaining 86 hypertensive patients, two possessed high (5 alpha THF + 5 beta THF)/THE ratios and 12.8% had high E/THE ratios. We observed a high percentage of alterations in cortisol metabolism at pre-receptor level in hypertensive patients, previously misclassified as essential. 11 beta-HSD2 and 5 beta-reductase decreased activity and imbalance of 11 beta-HSDs should be considered in the future management of hypertensive patients.
- Item(13)C NMR studies of heterocyclic naphtho- and anthraquinones. Deshielding effect on the carbonyl carbon with methyl substitution(2008) Salas Sánchez, Cristián Osvaldo; Armstrong Lattapiat, Ana Verónica; López Astorga, Claudio; Tapia Apati, Ricardo
- Item14-day triple, 5-day concomitant, and 10-day sequential therapies for Helicobacter pylori infection in seven Latin American sites: a randomised trial(ELSEVIER SCIENCE INC, 2011) Greenberg, E. Robert; Anderson, Garnet L.; Morgan, Douglas R.; Torres, Javier; Chey, William D.; Eduardo Bravo, Luis; Dominguez, Ricardo L.; Ferreccio, Catterina; Herrero, Rolando; Lazcano Ponce, Eduardo C.; Mercedes Meza Montenegro, Maria; Pena, Rodolfo; Pena, Edgar M.; Salazar Martinez, Eduardo; Correa, Pelayo; Elena Martinez, Maria; Valdivieso, Manuel; Goodman, Gary E.; Crowley, John J.; Baker, Laurence H.Background Evidence from Europe, Asia, and North America suggests that standard three-drug regimens of a proton-pump inhibitor plus amoxicillin and clarithromycin are significantly less effective for eradication of Helicobacter pylori infection than are 5-day concomitant and 10-day sequential four-drug regimens that include a nitroimidazole. These four-drug regimens also entail fewer antibiotic doses than do three-drug regimens and thus could be suitable for eradication programmes in low-resource settings. Few studies in Latin America have been done, where the burden of H pylori-associated diseases is high. We therefore did a randomised trial in Latin America comparing the effectiveness of four-drug regimens given concomitantly or sequentially with that of a standard 14-day regimen of triple therapy.
- Item2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors(2010) Luhr, Susan; Vilches-Herrera, Marcelo; Fierro Huerta, Angélica; Ramsay, Rona R.; Edmondson, Dale E.; Reyes-Parada, Miguel; Cassels, Bruce K.; Iturriaga-Vasquez, Patricio
- Item2D Autocorrelation modeling of the activity of trihalobenzocycloheptapyridine analogues as farnesyl protein transferase inhibitors(2005) Fernandez, M.; Tundidor Camba, Alain; Caballero, J.
- Item3,5-Dimethyl-1-(4-nitrophenyl)-4-[(E)-(2,3,4,5,6-pentafluorophenyl) diazenyl]-1H-pyrazole(2007) Bustos, Carlos; Sánchez Villalón, Christián Orlando; Schott Verdugo, Eduardo Enrique; Alvarez-Thon, Luis; Fuentealba, Mauricio
- Item3D free-breathing cardiac magnetic resonance fingerprinting(2020) Cruz, G.; Jaubert, O.; Qi, H. K.; Bustin, A.; Milotta, G.; Schneider, T.; Koken, P.; Doneva, M.; Botnar, René Michael; Prieto Vásquez, Claudia
- Item3D MR coronary artery segmentation(LIPPINCOTT WILLIAMS & WILKINS, 1998) Cline, HE; Thedens, DR; Irarrazaval, P; Meyer, CH; Hu, BS; Nishimura, DG; Ludke, SCoronary arteries are segmented from the blood pool using mathematical morphology operations from a 3D magnetic resonance spiral acquisition on a continuously breathing healthy volunteer. The segmented volume is maximal intensity projected at different views to yield coronary angiograms showing the left anterior descending artery (LAD), right coronary artery (RCA), and left circumflex artery (LCX), Magnetic resonance coronary angiography provides a retrospective rotating view of the coronary artery tree that complements oblique reformatted sections.
- Item3D Undersampled Golden-Radial Phase Encoding for DCE-MRA Using Inherently Regularized Iterative SENSE(2010) Prieto, Claudia; Uribe Arancibia, Sergio A.; Razavi, Reza; Atkinson, David; Schaeffter, Tobias
- Item3D whole-heart free-breathing qBOOST-T2 mapping(2020) Milotta, G.; Ginami, G.; Bustin, A.; Neji, R.; Prieto Vásquez, Claudia; Botnar, René Michael
- Item3D whole-heart isotropic-resolution motion-compensated joint T-1/T(2)mapping and water/fat imaging(2020) Milotta, Giorgia; Bustin, Aurelien; Jaubert, Olivier; Neji, Radhouene; Prieto Vásquez, Claudia; Botnar, René MichaelPurpose To develop a free-breathing isotropic-resolution whole-heart joint T1 and T2 mapping sequence with Dixon-encoding that provides coregistered 3D T1 and T2 maps and complementary 3D anatomical water and fat images in a single ~9 min scan. Methods Four interleaved dual-echo Dixon gradient echo volumes are acquired with a variable density Cartesian trajectory and different preparation pulses: 1) inversion recovery-preparation, 2) and 3) no preparations, and 4) T2 preparation. Image navigators are acquired to correct each echo for 2D translational respiratory motion; the 8 echoes are jointly reconstructed with a low-rank patch-based reconstruction. A water/fat separation algorithm is used to obtain water and fat images for each acquired volume. T1 and T2 maps are generated by matching the signal evolution of the water images to a simulated dictionary. Complementary bright-blood and fat volumes for anatomical visualization are obtained from the T2-prepared dataset. The proposed sequence was tested in phantom experiments and 10 healthy subjects and compared to standard 2D MOLLI T1 mapping, 2D balance steady-state free precession T2 mapping, and 3D T2-prepared Dixon coronary MR angiography. Results High linear correlation was found between T1 and T2 quantification with the proposed approach and phantom spin echo measurements (y = 1.1 × −11.68, R2 = 0.98; and y = 0.85 × +5.7, R2 = 0.99). Mean myocardial values of T1/T2 = 1116 ± 30.5 ms/45.1 ± 2.38 ms were measured in vivo. Biases of T1/T2 = 101.8 ms/−0.77 ms were obtained compared to standard 2D techniques. Conclusion The proposed joint T1/T2 sequence permitted the acquisition of motion-compensated isotropic-resolution 3D T1 and T2 maps and complementary coronary MR angiography and fat volumes, showing promising results in terms of T1 and T2 quantification and visualization of cardiac anatomy and pericardial fat.
- Item4-Methylthioamphetamine Increases Dopamine in the Rat Striatum and has Rewarding Effects In Vivo(2012) Sotomayor Zárate, Ramón Eduardo; Quiroz, Gabriel; Araya Gutiérrez, Katherine Angélica; Abarca, Jorge; Ibañez, Maria R.; Montecinos, Alejandro; Guajardo, Carlos; Nuñez, Gabriel; Fierro Huerta, Angélica; Moya, Pablo R.; Iturriaga-Vasquez, Patricio; Gomez-Molina, Cristobal; Gysling Caselli, Katia
- Item4-{3,5-Dimethyl-4-[(E)-(4-methylphenyl)diazenyl]-1H-pyrazol-1-yl}benzonitrile(2006) Bustos, Carlos; Schott Verdugo, Eduardo Enrique; Mac-Leod-Carey, Desmond A.; Ibañez, Andres; Alvarez-Thon, Luis
- Item7-(tert-Butyldiphenylsilyloxy)-2,2-dimethyl-1-benzofuran-3(2H)-one(2011) Salas Sánchez, Cristián Osvaldo; Tapia Apati, Ricardo; Macias, Alejandro
- ItemA 12-point checklist for surveillance of diseases of aquatic organisms: a novel approach to assist multidisciplinary teams in developing countries(2021) Bondad Reantaso, Melba G.; Fejzic, Nihad; MacKinnon, Brett; Huchzermeyer, David; Seric Haracic, Sabina; Mardone, Fernando O.; Vishnumurthy Mohan, Chadag; Taylor, Nick; Jansen, Mona Dverdal; Tavornpanich, Saraya; Hao, Bin; Huang, Jie; Leaño, Eduardo M.; Li, Qing; Liang, Yan; Dall’occo, Andrea
- ItemA 3D trajectory for undersampling k-space in MRSI applications(ELSEVIER SCIENCE INC, 2007) Uribe, Sergio; Guesalaga, Andres; Mir, Roberto; Guarini, Marcelo; Irarrazaval, PabloMagnetic resonance spectroscopic imaging (MRSI) is a noninvasive technique for producing spatially localized spectra. MRSI presents the important challenge of reducing the scan time while maintaining the spatial resolution. The preferred approach for this is to use time-varying readout gradients to collect the spatial and chemical-shift information. Fast, three-dimensional (3D) spatial encoded methods also reduce the scan time. Despite the existence of several new and faster 3D encoded methods, or k-space trajectories, for magnetic resonance imaging (MRI), only stack of spirals and echo planar have been studied in 3D MRSI. A novel formulation for designing fast, 3D k-space trajectory applicable to 3D MRSI is presented. This approach is simple and consists of rays expanding from the origin of k-space into a revolving sphere, collecting spectral data of all 3D spatial k-space at different times in the same scan. This article describes this new method and presents some results of its application to 3D MRSI. This technique allows some degree of undersampling; hence, it is possible to reconstruct high-quality undersampled spectroscopic imaging in order to recognize different compounds in short scan times. Additionally, the method is tested in regular 3D MRI. This proposed method can also be used for dynamic undersampled imaging. (c) 2007 Elsevier Inc. All rights reserved.