Browsing by Author "Cortes, Manuel"

Now showing 1 - 4 of 4
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    Mild and rapid method for the generation of o-quinone methide intermediates.: Synthesis of puupehedione analogues
    (2006) Barrero, Alejandro F.; del Moral, Jose F. Quilez; Herrador, M. Mar; Arteaga, Pilar; Cortes, Manuel; Benites, Julio; Rosellon, Antonio
    A route to simpler analogues to bioactive puupehedione derivatives involving a hetero Diels-Alder cycloaddition of a o-quinone methide is described. These intermediate species are generated via fluoride-induced desilylation of silyl derivatives of o-hydroxybenzyl iodides. Remarkable short reaction times and very mild experimental conditions are the main features of this method. (c) 2006 Elsevier Ltd. All rights reserved.
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    New cyclic acetals related to Ambergris and their olfactory evaluation
    (SAGE PUBLICATIONS LTD, 2006) Benites, Julio; Armstrong, Veronica; Cortes, Manuel
    Hemisyntheses of cyclic acetals (11-18) were performed using (-)-polygodial and (+)-confertifolin as chiral starting materials. The acetals obtained were evaluated for their odoriferous properties.
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    Solid-phase selenium-catalyzed selective allylic chlorination of polyprenoids
    (2006) Barrero, Alejandro F.; Quilez del Moral, Jose F.; Mar Herrador, M.; Cortes, Manuel; Arteaga, Pilar; Catalan, Julieta V.; Sanchez, Elena M.; Arteaga, Jesus F.
    Regioselective halogenation of the terminal isopropylidene unit of different acyclic polyolefinic polyprenoids (farnesyl acetate, geranylgeranyl acetate, squalene, etc.) using NCS/ catalytic polymer-supported selenenyl bromide is described; good to excellent yields are obtained (68-96%). The first applications of this protocol include the concise synthesis of bioactive terpenoids 1-3.
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    The preparation of oxygenated derivatives of ambrox and isoambrox from drimenol
    (2006) Benites, Julio; Lopez, Jose; Farias, Jorge G.; Cortes, Manuel
    The preparation of oxygenated derivatives of ambrox and isoambrox is described. The compounds 7 alpha-hydroxy-isoambrox, 7 beta-hydroxy-isoambrox, 7 alpha-hydroxy-ambrox, 7 beta-hydroxy-ainbrox, 7-oxo-isoambrox and 7-oxo-ambrox have been synthesized from (+drimenol, readily available from the bark of Drimys winteri. The structures of the products were determined mainly by spectroscopic methods.