Browsing by Author "Manzur Yanine, Alejandro"

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    Evidence for obtaining a second successive semen sample for intrauterine insemination in selected patients: Results from 32 consecutive cases
    (2016) Ortíz, Alejandra; Ortíz, Rita; Soto, Evelyn; Hartmann, Jonathan; Manzur Yanine, Alejandro; Marconi Toro, Marcelo Carlos
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    Progesterone-releasing vaginal ring for luteal phase support after superovulation and intrauterine insemination cycles, a pilot study
    (2013) Schwarze, J. E.; Villa, S.; Manzur Yanine, Alejandro; Magendzo, A.; Pommer, R.
    Objective: The main objective of this pilot study was to determine whether a progesterone-releasing vaginal ring is a good alternative for luteal phase support for patients undergoing intrauterine insemination after ovulation induction with sc gonadotrophins. Material and methods: We performed a multi-center study involving three different reproductive medicine units. Patients included were diagnosed with unexplained infertility and this was their first IUI cycle after ovulation induction with rFSH (Puregon ®) and ovulation induction with urinary HCG (Pregnyl ®). The day of insemination patients were randomized to receive luteal phase supplementation with progesterone vaginal ring (Fertiring ®) or no supplementation. Results: One hundred patients were invited to participate, and completed the study. Forty seven received luteal phase support with Fertiring ®. Overall the pregnancy rate was 15%. It was higher, although without reaching statistical significance, in the group receiving luteal phase support Fertirng ® (19.1%) than in the group without supplementation(11.3%). Conclusions: In this study, patients undergoing ovulation induction with Puregon ® and received luteal phase support with Fertiring ® showed a higher pregnancy rate than those who received no luteal phase support, although statistical significance was not achieved.
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    Rol de la laparoscopia en la infertilidad inexplicada. Experiencia del Hospital Clínico de la Pontificia Universidad Católica de Chile
    (2012) Pavlovic Bader, Milenko Tomislav; Manzur Yanine, Alejandro; Macaya P, R.
    The present study aims to explore the effectiveness of laparoscopic surgery on women presenting with infertility, of unidentified aetiology according to the standard infertility investigation, and recurrent failed In Vitro Fertilization (IVF) attempts. Identifying and correcting possible underlying pathologies by laparoscopy may subsequently enable natural conception in an effort to address infertility and avoid IVF overuse. One-hundred and seven (107) women with unidentified aetiology of infertility and recurrent failed IVF attempts met the inclusion criteria. Laparoscopic surgery was performed as the endpoint of the patients' diagnostic journey, aiming to identify a possible underlying factor as the cause of infertility. Sixty-two (62) out of 107 patients (57.94%) that underwent laparoscopy were diagnosed with endometriosis, 25 out of the 107 patients (23.3%) were diagnosed with periadnixal and pelvic adhesions, and 20 cases (18.69%) presented with no pathology and remained unexplained. Following identification and correction of endometriosis and pelvic adhesions, patients were invited to conceive naturally. For the patients that laparoscopic investigation failed to reveal any pathology they were categorized as unexplained infertility and were subjected to a single IVF cycle. Natural conception success rate within the first postoperative year was the primary outcome. Within the first postoperative year, 30 out of 62 patients (48.38%) diagnosed with endometriosis following laparoscopic investigation achieved a natural conception, and 28 out of them (93.4%) reported live-births. Additionally, 11 out of 25 patients (44%) diagnosed with periadnixal and pelvic adhesions achieved natural conception within the first operative year. Regarding the group of unexplained infertility patients, only four out of the 20 patients (20%) achieved clinical pregnancy in the first post-operative IVF cycle. In conclusion, laparoscopy appears to be a promising approach, addressing infertility, providing significant diagnostic findings, while avoiding IVF overuse regarding patients of unidentified infertility presenting with recurrent failed IVF attempts.