Progesterone-releasing vaginal ring for luteal phase support after superovulation and intrauterine insemination cycles, a pilot study
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Date
2013
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Abstract
Objective: The main objective of this pilot study was to determine whether a progesterone-releasing vaginal ring is a good alternative for luteal phase support for patients undergoing intrauterine insemination after ovulation induction with sc gonadotrophins. Material and methods: We performed a multi-center study involving three different reproductive medicine units. Patients included were diagnosed with unexplained infertility and this was their first IUI cycle after ovulation induction with rFSH (Puregon ®) and ovulation induction with urinary HCG (Pregnyl ®). The day of insemination patients were randomized to receive luteal phase supplementation with progesterone vaginal ring (Fertiring ®) or no supplementation. Results: One hundred patients were invited to participate, and completed the study. Forty seven received luteal phase support with Fertiring ®. Overall the pregnancy rate was 15%. It was higher, although without reaching statistical significance, in the group receiving luteal phase support Fertirng ® (19.1%) than in the group without supplementation(11.3%). Conclusions: In this study, patients undergoing ovulation induction with Puregon ® and received luteal phase support with Fertiring ® showed a higher pregnancy rate than those who received no luteal phase support, although statistical significance was not achieved.
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Keywords
Chorionic gonadotropin, Progesterone, Recombinant follitropin, Adult, Article, Controlled study, Female, Female infertility, Human, Intrauterine insemination, Intrauterine insemination, Luteal phase, Major clinical study, Ovulation induction, Pilot study, Pregnancy rate, Pregnancy test, Progesterone release, Superovulation, Transvaginal echography, Vagina ring