The identification of two subgroups of obese women with differing endometrial proliferation levels: potential consequences in the development of endometrial cancer

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dc.contributor.authorVillavicencio, A.
dc.contributor.authorAguilar, G.
dc.contributor.authorAcuna, J.
dc.contributor.authorGabler, F.
dc.contributor.authorSoto, E.
dc.contributor.authorGaete, F.
dc.contributor.authorPenaloza, P.
dc.contributor.authorCelis, M.
dc.contributor.authorOwen, G. I.
dc.date.accessioned2025-01-20T23:57:30Z
dc.date.available2025-01-20T23:57:30Z
dc.date.issued2012
dc.description.abstractEnhanced endometrial proliferation correlates obesity to type-I (estrogen-dependent) endometrial cancer (EC). Our aim was to distinguish obese women (without EC) with differing endometrial proliferation. Endometrial and blood samples were obtained from normal-weight and obese women without EC. Type-I EC samples were obtained from obese patients. On measuring endometrial proliferation (Ki67 and phosphorylated histone H3 (p-H3)), two groups of obese women without EC were identified: obese(High Proliferating) (O-HP) and obese(Low Proliferating) (O-LP). Increased Ki67 (88.5%, P<0.001), p-H3 (62.6%, P<0.01), 17 beta-estradiol/progesterone ratio (46.3%, P<0.01) and endometrial estrogen receptor alpha (ER alpha) (82.2%, P<0.001) were observed in O-HP compared with O-LP patients. ECs possessed similar ER alpha and enhanced proliferation as O-HP, suggesting that O-HP women are at higher risk of type-I EC. O-LP women were indistinguishable from normal-weight women regarding these determinants of endometrial proliferation, ER alpha and 17 beta-estradiol/progesterone ratio. Our data may further define the obesity phenotype in regards to type-I EC risk and may help identify obese women more susceptible to develop type-I EC, allowing early intervention and a potential reduction in mortality.
dc.description.funderFondo Nacional de Desarrollo Cientifico y Tecnologico
dc.fuente.origenWOS
dc.identifier.doi10.1038/ijo.2011.189
dc.identifier.issn0307-0565
dc.identifier.urihttps://doi.org/10.1038/ijo.2011.189
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95209
dc.identifier.wosidWOS:000306273300020
dc.issue.numero7
dc.language.isoen
dc.pagina.final1015
dc.pagina.inicio1012
dc.revistaInternational journal of obesity
dc.rightsacceso restringido
dc.subjectendometrium
dc.subjectproliferation
dc.subjectestrogen
dc.subjectcancer
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe identification of two subgroups of obese women with differing endometrial proliferation levels: potential consequences in the development of endometrial cancer
dc.typeartículo
dc.volumen36
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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