Spatial clusters, temporal behavior, and risk factors analysis of rabies in livestock in Ecuador

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dc.contributor.authorBriceno-Loaiza, Cesar
dc.contributor.authorFernandez-Sanhueza, Bastian
dc.contributor.authorBenavides-Silva, Cesar
dc.contributor.authorJimenez, Jose Yaguana
dc.contributor.authorRubio, Andre, V
dc.contributor.authorAbalos, Pedro
dc.contributor.authorAlegria-Moran, Raill A.
dc.date.accessioned2025-01-20T16:19:26Z
dc.date.available2025-01-20T16:19:26Z
dc.date.issued2024
dc.description.abstractRabies, a globally distributed and highly lethal zoonotic neglected tropical disease, has a significant impact in South America. In Ecuador, animal rabies cases are primarily linked to livestock, and hematophagous bats play a crucial role in disease transmission. This study aims to identify temporal trends, spatial patterns, and risk factors for animal rabies in Ecuador between 2014 and 2019. Epidemiological survey reports from the official Animal Rabies Surveillance Program of the Phyto and Zoosanitary Regulation and Control Agency of Ecuador (AGROCALIDAD) were used. The Animal Rabies Surveillance Program from AGROCALIDAD consists of an official passive surveillance program that receives reports from farmers or individuals (both trained or untrained) who have observed animals with neurological clinical signs and lesions compatible with bat bites, or who have seen or captured bats on their farms or houses. Once this report is made, AGROCALIDAD personnel is sent for field inspection, having to confirm the suspicion of rabies based on farm conditions and compatibility of signs. AGROCALIDAD personnel collect samples from all suspicious animals, which are further processed and analyzed using the Direct Fluorescent Antibody (DFA) test for rabies confirmatory diagnosis. In this case, study data comprised 846 bovine farms (with intra-farm sample sizes ranging from 1 to 16 samples) located in different ecoregions of Ecuador; out of these, 397 (46.93%) farms tested positive for animal rabies, revealing six statistically significant spatial clusters. Among these clusters, three high-risk areas were identified in the southeast of Ecuador. Seasonality was confirmed by the Ljung-Box test for both the number of cases (p < 0.001) and the positivity rate (p < 0.001). The Pacific Coastal lowlands and Sierra regions showed a lower risk of positivity compared to Amazonia (OR = 0.529; 95% CI = 0.318 - 0.883; p = 0.015 and OR = 0.633; 95% CI = 0.410 - 0.977; p = 0.039, respectively). The breeding of non-bovine animal species demonstrated a lower risk of positivity to animal rabies when compared to bovine (OR = 0.145; 95% CI = 0.062 - 0.339; p < 0.001). Similarly, older animals exhibited a lower risk (OR = 0.974; 95% CI = 0.967 - 0.981; p < 0.001). Rainfall during the rainy season was also found to decrease the risk of positivity to animal rabies (OR = 0.996; 95% CI = 0.995 - 0.998; p < 0.001). This study underscores the significance of strengthening the national surveillance program for the prevention and control of animal rabies in Ecuador and other countries facing similar epidemiological, social, and geographical circumstances.
dc.description.funderChilean Agency for International Development Cooperation (AGCID)
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.prevetmed.2024.106188
dc.identifier.eissn1873-1716
dc.identifier.issn0167-5877
dc.identifier.urihttps://doi.org/10.1016/j.prevetmed.2024.106188
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90690
dc.identifier.wosidWOS:001215963100001
dc.language.isoen
dc.revistaPreventive veterinary medicine
dc.rightsacceso restringido
dc.subjectAnimal rabies
dc.subjectEcuador
dc.subjectTemporal trends
dc.subjectSpatial clusters
dc.subjectZoonotic disease surveillance
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSpatial clusters, temporal behavior, and risk factors analysis of rabies in livestock in Ecuador
dc.typeartículo
dc.volumen226
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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