The concentration of surfactant protein - A in amniotic fluid decreases in spontaneous human parturition at term

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dc.contributor.authorChaiworapongsa, Tinnakorn
dc.contributor.authorHong, Joon Seok
dc.contributor.authorHull, William M.
dc.contributor.authorKim, Chong Jai
dc.contributor.authorGomez, Ricardo
dc.contributor.authorMazor, Moshe
dc.contributor.authorRomero, Roberto
dc.contributor.authorWhitsett, Jeffrey A.
dc.date.accessioned2024-01-10T12:09:25Z
dc.date.available2024-01-10T12:09:25Z
dc.date.issued2008
dc.description.abstractObjective. The fetus is thought to play a central role in the onset of labor. Pulmonary surfactant protein (SP)-A, secreted by the maturing fetal lung, has been implicated in the mechanisms initiating parturition in mice. The present study was conducted to determine whether amniotic fluid concentrations of SP-A and SP-B change during human parturition. Study design. Amniotic fluid SP-A and SP-B concentrations were measured with a sensitive and specific ELISA in the following groups of pregnant women: (1) mid-trimester of pregnancy, between 15 and 18 weeks of gestation (n=29), (2) term pregnancy not in labor (n=28), and (3) term pregnancy in spontaneous labor (n=26). Non-parametric statistics were used for analysis. Results. SP-A was detected in all amniotic fluid samples. SP-B was detected in 24.1% (7/29) of mid-trimester samples and in all samples at term. The median amniotic fluid concentrations of SP-A and SP-B were significantly higher in women at term than in women in the mid-trimester (SP-A term no labor: median 5.6g/mL, range 2.2-15.2g/mL vs. mid-trimester: median 1.64g/mL, range 0.1-4.7g/mL, and SP-B term no labor: median 0.54g/mL, range 0.17-1.99g/mL vs. mid-trimester: median 0g/mL, range 0-0.35g/mL; both p0.001). The median amniotic fluid SP-A concentration in women at term in labor was significantly lower than that in women at term not in labor (term in labor: median 2.7g/mL, range 1.2-10.1g/mL vs. term no labor: median 5.6g/mL, range 2.2-15.2g/mL; p0.001). There was no significant difference in the median amniotic fluid SP-B concentrations between women in labor and those not in labor (term in labor: median 0.47g/mL, range 0.04-1.32g/mL vs. term no labor: median 0.54g/mL, range 0.17-1.99g/mL; p=0.2). Conclusion. The amniotic fluid concentration of SP-A decreases in spontaneous human parturition at term.
dc.description.funderEunice Kennedy Shriver National Institute of Child Health and Human Development
dc.description.funderNIH
dc.description.funderDHHS
dc.description.funderEUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
dc.description.funderEUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1080/14767050802215193
dc.identifier.eissn1476-4954
dc.identifier.issn1476-7058
dc.identifier.pubmedidMEDLINE:18828058
dc.identifier.urihttps://doi.org/10.1080/14767050802215193
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76488
dc.identifier.wosidWOS:000259695900010
dc.information.autorucMedicina;Gómez R;S/I;80926
dc.issue.numero9
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final659
dc.pagina.inicio652
dc.publisherTAYLOR & FRANCIS LTD
dc.revistaJOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
dc.rightsregistro bibliográfico
dc.subjectsurfactant protein
dc.subjectSP-A
dc.subjectSP-B
dc.subjectamniotic fluid
dc.subjectterm
dc.subjectlabor
dc.subjectparturition
dc.subjectA-DEFICIENT MICE
dc.subjectPULMONARY SURFACTANT
dc.subjectII CELLS
dc.subjectPRETERM PARTURITION
dc.subjectMICROBIAL INVASION
dc.subjectSPONTANEOUS LABOR
dc.subjectFETAL MEMBRANES
dc.subjectMESSENGER-RNA
dc.subjectLUNG MATURITY
dc.subjectSP-B
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe concentration of surfactant protein - A in amniotic fluid decreases in spontaneous human parturition at term
dc.typeartículo
dc.volumen21
sipa.codpersvinculados80926
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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