Real-Time fMRI Neurofeedback Training of Selective Attention in Older Adults

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dc.contributor.authorLin, Tian
dc.contributor.authorRana, Mohit
dc.contributor.authorLiu, Peiwei
dc.contributor.authorPolk, Rebecca
dc.contributor.authorHeemskerk, Amber
dc.contributor.authorWeisberg, Steven M.
dc.contributor.authorBowers, Dawn
dc.contributor.authorSitaram, Ranganatha
dc.contributor.authorEbner, Natalie C.
dc.date.accessioned2025-01-20T16:07:50Z
dc.date.available2025-01-20T16:07:50Z
dc.date.issued2024
dc.description.abstractBackground: Selective attention declines with age, due to age-related functional changes in dorsal anterior cingulate cortex (dACC). Real-time functional magnetic resonance imaging (rtfMRI) neurofeedback has been used in young adults to train volitional control of brain activity, including in dACC. Methods: For the first time, this study used rtfMRI neurofeedback to train 19 young and 27 older adults in volitional up- or down-regulation of bilateral dACC during a selective attention task. Results: Older participants in the up-regulation condition (experimental group) showed greater reward points and dACC BOLD signal across training sessions, reflective of neurofeedback training success; and faster reaction time and better response accuracy, suggesting behavioral benefits on selective attention. These effects were not observed for older participants in the down-regulation condition (inverse condition control group), supporting specificity of volitional dACC up-regulation training in older adults. These effects were, unexpectedly, also not observed for young participants in the up-regulation condition (age control group), perhaps due to a lack of motivation to continue the training. Conclusions: These findings provide promising first evidence of functional plasticity in dACC in late life via rtfMRI neurofeedback up-regulation training, enhancing selective attention, and demonstrate proof of concept of rtfMRI neurofeedback training in cognitive aging.
dc.fuente.origenWOS
dc.identifier.doi10.3390/brainsci14090931
dc.identifier.eissn2076-3425
dc.identifier.urihttps://doi.org/10.3390/brainsci14090931
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90028
dc.identifier.wosidWOS:001323221800001
dc.issue.numero9
dc.language.isoen
dc.revistaBrain sciences
dc.rightsacceso restringido
dc.subjectrtfMRI
dc.subjectneurofeedback training
dc.subjectold age
dc.subjectselective attention
dc.subjectdACC
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleReal-Time fMRI Neurofeedback Training of Selective Attention in Older Adults
dc.typeartículo
dc.volumen14
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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