In vivo micro computed tomography detection and decrease in amyloid load by using multifunctionalized gold nanorods: a neurotheranostic platform for Alzheimer's disease

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dc.catalogadorjwg
dc.contributor.authorMorales Zavala, Francisco
dc.contributor.authorJara Guajardo, Pedro
dc.contributor.authorChamorro Veloso, David Daniel
dc.contributor.authorRiveros, Ana L.
dc.contributor.authorChandia Cristi, América Valeska
dc.contributor.authorSalgado Cortés, Nicole Andrea
dc.contributor.authorPismante, Paola
dc.contributor.authorGiralt, Ernest
dc.contributor.authorSanchez Navarro, Macarena
dc.contributor.authorAraya, Eyleen
dc.contributor.authorVasquez, Rodrigo
dc.contributor.authorAcosta, Gerardo
dc.contributor.authorAlbericio, Fernando
dc.contributor.authorAlvarez, Alejandra R.
dc.contributor.authorKogan, Marcelo J.
dc.date.accessioned2024-01-30T20:04:47Z
dc.date.available2024-01-30T20:04:47Z
dc.date.issued2021
dc.description.abstractThe development and use of nanosystems is an emerging strategy for the diagnosis and treatment of a broad number of diseases, such as Alzheimer's disease (AD). Here, we developed a neurotheranostic nanosystem based on gold nanorods (GNRs) that works as a therapeutic peptide delivery system and can be detected in vivo for microcomputed tomography (micro-CT), being a diagnostic tool. GNRs functionalized with the peptides Ang2 (a shuttle to the Central Nervous System) and D1 (that binds to the A beta peptide, also inhibiting its aggregation) allowed detecting differences in vivo between wild type and AD mice (APPswe/PSEN1dE9) 15 minutes after a single dose by micro-CT. Moreover, after a recurrent treatment for one month with GNRs-D1/Ang2, we observed a diminution of amyloid load and inflammatory markers in the brain. Thus, this new designed nanosystem exhibits promising properties for neurotheranostics of AD.
dc.description.funderUniversidad de Chile
dc.description.funderFondequip grant
dc.description.funderFondecyt grant
dc.description.funderFondap grant
dc.description.funderBeca Doctorado grant
dc.fechaingreso.objetodigital2024-12-12
dc.format.extent13 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1039/d0bm01825b
dc.identifier.eissn2047-4849
dc.identifier.issn2047-4830
dc.identifier.pubmedidMEDLINE:33982040
dc.identifier.urihttps://doi.org/10.1039/d0bm01825b
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81083
dc.identifier.wosidWOS:000649682900001
dc.information.autorucFacultad de Ciencias Biológicas; Chamorro Veloso David Daniel; ; 125733
dc.information.autorucEscuela de Medicina; Salgado Cortes Nicole Andrea; 0000-0003-1658-9641; 195452
dc.information.autorucFacultad de Ciencias Biológicas; Chandia Cristi America Valeska; ; 237253
dc.language.isoen
dc.nota.accesoContenido parcial
dc.publisherRoyal Soc Chemistry
dc.revistaBiomaterials Science
dc.rightsacceso restringido
dc.subjectCentral-Nervous-System
dc.subjectPlasmonic Photothermal Therapy
dc.subjectTransgenic Mice
dc.subjectBeta Oligomers
dc.subjectBiomedical Applications
dc.subjectMemory Deficits
dc.subjectBrain Delivery
dc.subjectNanoparticles
dc.subjectPeptide
dc.subjectTranscytosis
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleIn vivo micro computed tomography detection and decrease in amyloid load by using multifunctionalized gold nanorods: a neurotheranostic platform for Alzheimer's disease
dc.typeartículo
sipa.codpersvinculados125733
sipa.codpersvinculados195452
sipa.codpersvinculados237253
sipa.trazabilidadORCID;2024-01-15
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