Methionine sulfoxide reductase A expression is regulated by the DAF-16/FOXO pathway in Caenorhabditis elegans

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dc.contributor.authorMinniti, Alicia N.
dc.contributor.authorCataldo, Romina
dc.contributor.authorTrigo, Carla
dc.contributor.authorVasquez, Luis
dc.contributor.authorMujica, Patricio
dc.contributor.authorLeighton, Federico
dc.contributor.authorInestrosa, Nibaldo C.
dc.contributor.authorAldunate, Rebeca
dc.date.accessioned2024-01-10T13:50:27Z
dc.date.available2024-01-10T13:50:27Z
dc.date.issued2009
dc.description.abstractP>The methionine sulfoxide reductase system has been implicated in aging and protection against oxidative stress. This conserved system reverses the oxidation of methionine residues within proteins. We analyzed one of the components of this system, the methionine sulfoxide reductase A gene, in Caenorhabditis elegans. We found that the msra-1 gene is expressed in most tissues, particularly in the intestine and the nervous system. Worms carrying a deletion of the msra-1 gene are more sensitive to oxidative stress, show chemotaxis and locomotory defects, and a 30% decrease in median survival. We established that msra-1 expression decreases during aging and is regulated by the DAF-16/FOXO3a transcription factor. The absence of this enzyme decreases median survival and affects oxidative stress resistance of long lived daf-2 worms. A similar effect of MSRA-1 absence in wild-type and daf-2 (where most antioxidant enzymes are activated) backgrounds, suggests that the lack of this member of the methionine repair system cannot be compensated by the general antioxidant response. Moreover, FOXO3a directly activates the human MsrA promoter in a cell culture system, implying that this could be a conserved mechanism of MsrA regulation. Our results suggest that repair of oxidative damage in proteins influences the rate at which tissues age. This repair mechanism, rather than the general decreased of radical oxygen species levels, could be one of the main determinants of organisms' lifespan.
dc.description.funderFondecyt
dc.description.funderFONDAP- Biomedicine
dc.description.funderMillennium Institute of Fundamental and Applied Biology (MIFAB)
dc.description.funderCenter for Aging and Regeneration (CARE)
dc.description.funderBase Financing Program for Scientific and Technological Centers of Excellence
dc.description.funderCONICYT
dc.description.funderNIH National Center for Research Resources (NCRR)
dc.description.funderNational Bioresource Project
dc.fechaingreso.objetodigital2024-05-13
dc.format.extent16 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1111/j.1474-9726.2009.00521.x
dc.identifier.issn1474-9726
dc.identifier.pubmedidMEDLINE:19747232
dc.identifier.urihttps://doi.org/10.1111/j.1474-9726.2009.00521.x
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79532
dc.identifier.wosidWOS:000271972600008
dc.information.autorucCiencias Biológicas;Aldunate R;S/I;494
dc.information.autorucCiencias Biológicas;Inestrosa N;S/I;99331
dc.information.autorucCiencias Biológicas;Leighton F;S/I;98261
dc.information.autorucCiencias Biológicas;Minniti AN;S/I;129451
dc.information.autorucCiencias Biológicas;Mujica P;S/I;149699
dc.information.autorucCiencias Biológicas;Vásquez L;S/I;159620
dc.issue.numero6
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final705
dc.pagina.inicio690
dc.publisherWILEY
dc.revistaAGING CELL
dc.rightsregistro bibliográfico
dc.subjectaging
dc.subjectC
dc.subjectelegans
dc.subjectFOXO
dc.subjectMSRA-1
dc.subjectoxidative stress
dc.subjectprotein repair
dc.subjectFOXO TRANSCRIPTION FACTORS
dc.subjectC-ELEGANS
dc.subjectLIFE-SPAN
dc.subjectOXIDATIVE STRESS
dc.subjectANTIOXIDANT DEFENSE
dc.subjectPROTEIN OXIDATION
dc.subjectR-SULFOXIDE
dc.subjectLONGEVITY
dc.subjectPEPTIDE
dc.subjectMSRA
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMethionine sulfoxide reductase A expression is regulated by the DAF-16/FOXO pathway in Caenorhabditis elegans
dc.typeartículo
dc.volumen8
sipa.codpersvinculados494
sipa.codpersvinculados99331
sipa.codpersvinculados98261
sipa.codpersvinculados129451
sipa.codpersvinculados149699
sipa.codpersvinculados159620
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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