New three-arm amphiphilic and biodegradable block copolymers composed of poly(6-caprolactone) and poly(N-vinyl-2-pyrrolidone). Synthesis, characterization and self-assembly in aqueous solution

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dc.contributor.authorLeiva, Angel
dc.contributor.authorQuina, Frank H.
dc.contributor.authorAraneda, Emilio
dc.contributor.authorGargallo, Ligia
dc.contributor.authorRadic, Deodato
dc.date.accessioned2024-01-10T12:06:55Z
dc.date.available2024-01-10T12:06:55Z
dc.date.issued2007
dc.description.abstractThe synthesis, characterization and the self-assembly process of a novel biodegradable block copolymer containing a poly (epsilon-caprolactone), PCL, central block and three poly(N-vinyl-2-pyrrolidone), PVP, arms are reported. Three samples with different amounts of PVP were investigated. The copolymers were characterized by FTIR spectroscopy, H-1 NMR and viscosity measurements. The composition and the molecular weights of the block copolymers were established using size exclusion chromatography SEC and H-1 NMR. Micelle formation by these copolymers was monitored by using the vibrational fine structure of pyrene monomer fluorescence and the critical aggregation concentrations, cac, of the copolymers in aqueous solution were determined using sigmoid Boltzmann-type fitting of the fluorescence data. Dynamic light scattering measurements showed a bimodal size distribution for the copolymers in solution, indicating that the micellization is an intermolecular process. Partitioning coefficients of pyrene between copolymer micelles and water were also determined and increase in magnitude with increasing 8-caprolactone content of the copolymer. (c) 2007 Elsevier Inc. All rights reserved.
dc.fechaingreso.objetodigital27-03-2024
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.jcis.2007.01.013
dc.identifier.issn0021-9797
dc.identifier.pubmedidMEDLINE:17368468
dc.identifier.urihttps://doi.org/10.1016/j.jcis.2007.01.013
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76222
dc.identifier.wosidWOS:000245967500016
dc.information.autorucQuímica;Gargallo L;S/I;98194
dc.information.autorucQuímica;Leiva A;S/I;88381
dc.information.autorucQuímica;Radic D;S/I;49367
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final143
dc.pagina.inicio136
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE
dc.revistaJOURNAL OF COLLOID AND INTERFACE SCIENCE
dc.rightsacceso restringido
dc.subjectDRUG-DELIVERY
dc.subjectMICELLE FORMATION
dc.subjectOXIDE) MICELLES
dc.subjectMICELLIZATION
dc.subjectN-(2-HYDROXYPROPYL)METHACRYLAMIDE
dc.subjectPOLY(EPSILON-CAPROLACTONE)
dc.subjectN-VINYL-2-PYRROLIDONE
dc.subjectFLUORESCENCE
dc.subjectSURFACTANTS
dc.subjectTRIBLOCK
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNew three-arm amphiphilic and biodegradable block copolymers composed of poly(6-caprolactone) and poly(N-vinyl-2-pyrrolidone). Synthesis, characterization and self-assembly in aqueous solution
dc.typeartículo
dc.volumen310
sipa.codpersvinculados98194
sipa.codpersvinculados88381
sipa.codpersvinculados49367
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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