Human Respiratory Syncytial Virus: Infection and Pathology

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dc.catalogadorgjm
dc.contributor.authorBohmwald Prieto, Karen
dc.contributor.authorEspinoza Véliz, Janyra Alejandra
dc.contributor.authorRey Jurado, Emma
dc.contributor.authorGómez Johnson, Roberto Sebastian
dc.contributor.authorGonzález Muñoz, Pablo Alberto
dc.contributor.authorBueno Ramírez, Susan
dc.contributor.authorRiedel, Claudia A.
dc.contributor.authorKalergis Parra, Alexis Mikes
dc.date.accessioned2024-01-30T15:23:30Z
dc.date.available2024-01-30T15:23:30Z
dc.date.issued2016
dc.description.abstractThe human respiratory syncytial virus (hRSV) is by far the major cause of acute lower respiratory tract infections (ALRTIs) worldwide in infants and children younger than 2 years. The overwhelming number of hospitalizations due to hRSV-induced ALRTI each year is due, at least in part, to the lack of licensed vaccines against this virus. Thus, hRSV infection is considered a major public health problem and economic burden in most countries. The lung pathology developed in hRSV-infected individuals is characterized by an exacerbated proinflammatory and unbalanced Th2-type immune response. In addition to the adverse effects in airway tissues, hRSV infection can also cause neurologic manifestations in the host, such as seizures and encephalopathy. Although the origins of these extrapulmonary symptoms remain unclear, studies with patients suffering from neurological alterations suggest an involvement of the inflammatory response against hRSV. Furthermore, hRSV has evolved numerous mechanisms to modulate and evade the immune response in the host. Several studies have focused on elucidating the interactions between hRSV virulence factors and the host immune system, to rationally design new vaccines and therapies against this virus. Here, we discuss about the infection, pathology, and immune response triggered by hRSV in the host.
dc.fechaingreso.objetodigital2024-05-06
dc.fuente.origenORCID
dc.identifier.doi10.1055/s-0036-1584799
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-84982676254&partnerID=MN8TOARS
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81064
dc.information.autorucFacultad de Ciencias Biológicas; Bohmwald Prieto, Karen; S/I; 1007746
dc.information.autorucFacultad de Ciencias Biológicas; Espinoza Véliz, Janyra Alejandra; S/I; 225249
dc.information.autorucFacultad de Ciencias Biológicas; Gómez Johnson, Roberto Sebastian; S/I; 149736
dc.information.autorucFacultad de Ciencias Biológicas; González Muñoz, Pablo Alberto; 0000-0001-7709-6870; 15616
dc.information.autorucFacultad de Ciencias Biológicas; Bueno Ramírez, Susan; 0000-0002-7551-8088; 113541
dc.information.autorucFacultad de Ciencias Biológicas; Kalergis Parra, Alexis Mikes; 0000-0001-7622-5263; 90610
dc.language.isoen
dc.nota.accesoContenido completo
dc.rightsacceso abierto
dc.subjectAdaptive immune response
dc.subjectCentral nervous system
dc.subjectExtrapulmonary manifestations
dc.subjectHuman respiratory syncytial virus
dc.subjectInnate immune response
dc.subjectVirulence factors
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleHuman Respiratory Syncytial Virus: Infection and Pathology
dc.typeartículo
sipa.codpersvinculados1007746
sipa.codpersvinculados225249
sipa.codpersvinculados149736
sipa.codpersvinculados15616
sipa.codpersvinculados113541
sipa.codpersvinculados90610
sipa.trazabilidadORCID;2024-01-15
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