Comparison of two doses of aprotinin in patients receiving aspirin before coronary bypass surgery

Simple item page
dc.contributor.authorMoran, SV
dc.contributor.authorLema, G
dc.contributor.authorMedel, J
dc.contributor.authorIrarrazaval, MJ
dc.contributor.authorZalaquett, R
dc.contributor.authorGarayar, B
dc.contributor.authorFlaskamp, R
dc.date.accessioned2024-01-10T13:47:03Z
dc.date.available2024-01-10T13:47:03Z
dc.date.issued2000
dc.description.abstractThis study was designed to evaluate efficacy and tolerability of two different doses of aprotinin in patients receiving aspirin before undergoing coronary artery bypass grafting. Forty-two patients were randomized to receive either placebo (group I), or aprotinin in doses of 4 000 000 KIU (group II) or 6 000 000 KIU (group III). Drug efficacy was determined by measuring postoperative blood loss and transfusion of blood products. Both doses were effective in reducing blood loss and transfusion requirements. Blood loss through thoracotomy drainage was 450 +/- 224, 182 +/- 144, 142 +/- 98 mi, respectively, for control and treatment groups II and III (p = 0.0001). The numbers of patients with blood transfusions were seven (50%), two (17%) and two (17%) for group I and treatment groups II and ill, respectively (p = 0.10). Tolerability was excellent and complications few and reversible.
dc.description.abstractIn conclusion, high and medium doses of aprotinin were well tolerated and reduced bleeding and transfusion requirements in patients submitted to coronary bypass surgery under the effects of aspirin.
dc.fechaingreso.objetodigital2024-05-03
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1177/026765910001500204
dc.identifier.issn0267-6591
dc.identifier.pubmedidMEDLINE:10789564
dc.identifier.urihttps://doi.org/10.1177/026765910001500204
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79230
dc.identifier.wosidWOS:000086325100003
dc.information.autorucMedicina;Irarrázaval M;S/I;98706
dc.information.autorucMedicina;Lema G;S/I;99835
dc.information.autorucMedicina;Morán S;S/I;98562
dc.information.autorucMedicina;Zalaquett R;S/I;100042
dc.issue.numero2
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final110
dc.pagina.inicio105
dc.publisherARNOLD, HODDER HEADLINE PLC
dc.revistaPERFUSION-UK
dc.rightsregistro bibliográfico
dc.subjectOPEN-HEART SURGERY
dc.subjectCARDIOPULMONARY BYPASS
dc.subjectBLOOD-LOSS
dc.subjectMYOCARDIAL REVASCULARIZATION
dc.subjectTRANSFUSION
dc.subjectNEED
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleComparison of two doses of aprotinin in patients receiving aspirin before coronary bypass surgery
dc.typeartículo
dc.volumen15
sipa.codpersvinculados98706
sipa.codpersvinculados99835
sipa.codpersvinculados98562
sipa.codpersvinculados100042
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Comparison of two doses of aprotinin in patients receiving aspirin before coronary bypass surgery.pdf
Size:
97.82 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas