Rapid intraclonal switch of lineage dominance in congenital leukaemia with a MLL gene rearrangement

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dc.contributor.authorRidge, SA
dc.contributor.authorCabrera, ME
dc.contributor.authorFord, AM
dc.contributor.authorTapia, S
dc.contributor.authorRisueno, C
dc.contributor.authorLabra, S
dc.contributor.authorBarriga, F
dc.contributor.authorGreaves, MF
dc.date.accessioned2025-01-21T01:34:21Z
dc.date.available2025-01-21T01:34:21Z
dc.date.issued1995
dc.description.abstractWe describe a case of neonatal mixed lineage leukaemia which presented with a dominant B progenitor lymphoblast population plus a minor monocytic component. Treatment of the patient with corticosteroid and Ara-C resulted in loss of lymphoblasts and a rapid (within 7 days) increase and dominance of the monocytic component. The common clonal origin of the two cell types was evident from the identical rearrangement in the MLL gene and a shared rearrangement of one IGH allele. In common with other neonatal or infant ALL with MLL gene rearrangements, this leukaemia may have originated in a common B-monocytic lineage stem cell during foetal haemopoiesis. The observations further suggest that the therapeutic impact of the MLL gene rearrangement is to some extent dependent on the cellular context in which it is expressed.
dc.fuente.origenWOS
dc.identifier.issn0887-6924
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97547
dc.identifier.wosidWOS:A1995TQ15400007
dc.issue.numero12
dc.language.isoen
dc.pagina.final2026
dc.pagina.inicio2023
dc.revistaLeukemia
dc.rightsacceso restringido
dc.subjectMLL gene
dc.subjectmixed lineage leukaemia
dc.subjectlineage
dc.subjectgene rearrangement
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRapid intraclonal switch of lineage dominance in congenital leukaemia with a MLL gene rearrangement
dc.typeartículo
dc.volumen9
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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