Acetazolamide for the treatment of acute mountain sickness

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dc.catalogadordfo
dc.contributor.authorTapia Chávez, Luciano Dante
dc.contributor.authorIrarrázaval Domínguez, Sebastián
dc.date.accessioned2024-05-30T15:51:58Z
dc.date.available2024-05-30T15:51:58Z
dc.date.issued2019
dc.description.abstractIntroduction: Acute mountain sickness is the most prevalent illness related to acute exposure to high altitude, secondary to the hypobaric hypoxia effects in our body. Acetazolamide has been traditionally used for its prevention and treatment, however, there is still controversy regarding the degree of usefulness of this medication as monotherapy. Methods: We searched in Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis and generated a summary of findings table using the GRADE approach. Results and conclusions: We identified a systematic review that included two primary studies, both corresponding to randomized trials. We conclude that it is not possible to establish clearly whether treatment with acetazolamide reduces the symptoms of acute mountain disease or increases the risk of adverse effects, because the certainty of the existing evidence has been evaluated as very low.
dc.fuente.origenORCID
dc.identifier.doi10.5867/medwave.2019.11.7736
dc.identifier.issn0717-6384
dc.identifier.urihttps://doi.org/10.5867/medwave.2019.11.7736
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/85990
dc.information.autorucEscuela de Medicina; Tapia Chavez Luciano Dante; S/I; 223850
dc.information.autorucEscuela de Medicina; Irarrazaval Dominguez, Sebastian; 0000-0002-1215-1709; 12853
dc.issue.numero11
dc.language.isoen
dc.nota.accesoContenido parcial
dc.revistaMedwave
dc.rightsacceso restringido
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleAcetazolamide for the treatment of acute mountain sickness
dc.typeartículo
dc.volumen19
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