Pregnancy-specific responses to COVID-19 revealed by high-throughput proteomics of human plasma

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dc.contributor.authorGomez-Lopez, Nardhy
dc.contributor.authorRomero, Roberto
dc.contributor.authorEscobar, Maria Fernanda
dc.contributor.authorCarvajal, Javier Andres
dc.contributor.authorEchavarria, Maria Paula
dc.contributor.authorAlbornoz, Ludwig L.
dc.contributor.authorNasner, Daniela
dc.contributor.authorMiller, Derek
dc.contributor.authorGallo, Dahiana M.
dc.contributor.authorGalaz, Jose
dc.contributor.authorArenas-Hernandez, Marcia
dc.contributor.authorBhatti, Gaurav
dc.contributor.authorDone, Bogdan
dc.contributor.authorZambrano, Maria Andrea
dc.contributor.authorRamos, Isabella
dc.contributor.authorFernandez, Paula Andrea
dc.contributor.authorPosada, Leandro
dc.contributor.authorChaiworapongsa, Tinnakorn
dc.contributor.authorJung, Eunjung
dc.contributor.authorGarcia-Flores, Valeria
dc.contributor.authorSuksai, Manaphat
dc.contributor.authorGotsch, Francesca
dc.contributor.authorBosco, Mariachiara
dc.contributor.authorThan, Nandor Gabor
dc.contributor.authorTarca, Adi L.
dc.date.accessioned2025-01-20T20:15:41Z
dc.date.available2025-01-20T20:15:41Z
dc.date.issued2023
dc.description.abstractGomez-Lopez et al. profile the plasma proteome of pregnant and non-pregnant COVID-19 patients and controls. Shared and pregnancy-specific proteomic changes are identified in COVID-19 patients compared to controls, with the proteome accurately identifying COVID-19 patients, even when asymptomatic.
dc.description.abstractBackgroundPregnant women are at greater risk of adverse outcomes, including mortality, as well as obstetrical complications resulting from COVID-19. However, pregnancy-specific changes that underlie such worsened outcomes remain unclear.MethodsPlasma samples were collected from pregnant women and non-pregnant individuals (male and female) with (n = 72 pregnant, 52 non-pregnant) and without (n = 29 pregnant, 41 non-pregnant) COVID-19. COVID-19 patients were grouped as asymptomatic, mild, moderate, severe, or critically ill according to NIH classifications. Proteomic profiling of 7,288 analytes corresponding to 6,596 unique protein targets was performed using the SOMAmer platform.ResultsHerein, we profile the plasma proteome of pregnant and non-pregnant COVID-19 patients and controls and show alterations that display a dose-response relationship with disease severity; yet, such proteomic perturbations are dampened during pregnancy. In both pregnant and non-pregnant state, the proteome response induced by COVID-19 shows enrichment of mediators implicated in cytokine storm, endothelial dysfunction, and angiogenesis. Shared and pregnancy-specific proteomic changes are identified: pregnant women display a tailored response that may protect the conceptus from heightened inflammation, while non-pregnant individuals display a stronger response to repel infection. Furthermore, the plasma proteome can accurately identify COVID-19 patients, even when asymptomatic or with mild symptoms.ConclusionThis study represents the most comprehensive characterization of the plasma proteome of pregnant and non-pregnant COVID-19 patients. Our findings emphasize the distinct immune modulation between the non-pregnant and pregnant states, providing insight into the pathogenesis of COVID-19 as well as a potential explanation for the more severe outcomes observed in pregnant women.
dc.description.abstractPlain language summaryPregnant COVID-19 patients are at increased risk of experiencing complications and severe outcomes compared to the general population. However, the reasons for this heightened risk are still unclear. We measured the proteins present in the blood of pregnant and non-pregnant patients with COVID-19 and compared these to healthy individuals. We found that some COVID-19-associated proteins were present at lower levels in pregnant women, which could help to protect the fetus from harmful inflammation, the body's natural response to infection. While some proteins affected by COVID-19 are shared between pregnant and non-pregnant patients, others were distinctly affected only in pregnant women, providing a potential explanation for the more severe outcomes in this group.
dc.fuente.origenWOS
dc.identifier.doi10.1038/s43856-023-00268-y
dc.identifier.issn2730-664X
dc.identifier.urihttps://doi.org/10.1038/s43856-023-00268-y
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92277
dc.identifier.wosidWOS:000963090500001
dc.issue.numero1
dc.language.isoen
dc.revistaCommunications medicine
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePregnancy-specific responses to COVID-19 revealed by high-throughput proteomics of human plasma
dc.typeartículo
dc.volumen3
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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