Prenatal diagnosis and early neonatal management of patients with hypoplastic left heart syndrome: experience of a perinatal center

Simple item page
dc.contributor.authorCubillos Celis, Maria Paz
dc.contributor.authorMaccioni Romero, Andrea
dc.contributor.authorGalleguillos Galindo, Constanza
dc.contributor.authorGarrido Sepulveda, Claudia
dc.contributor.authorMartinovic, Carolina
dc.contributor.authorVargas Innocenti, Paula
dc.date.accessioned2025-01-20T22:18:15Z
dc.date.available2025-01-20T22:18:15Z
dc.date.issued2021
dc.description.abstractHypoplastic Left Heart Syndrome (HLHS) is the most common form of functional single-ventricle heart disease. Despite improvements in medical and surgical care, morbidity and mortality remain high, especially around the first surgical stage. Objective: To describe the clinical characteristics of newborns with HLHS, seen at a perinatal referral center. Patients and Method: Retrospective descriptive study of all newborns with pre and/or postnatal diagnosis of HLHS between 2014 and 2019 in the Complejo Asistencial Dr. Sotero del Rio. Medical records were reviewed collecting demographic and perinatal variables, clinical evolution, mortality associated with the first surgery, and survival at one year. Results: Nineteen patients were included. Most were term newborns and 13/19 were female. All had a prenatal diagnosis. Five patients had associated extracardiac anomalies. 16/19 required vasoactive drugs and 17/19 used invasive mechanical ventilation. Seven patients received enteral feeding, without episodes of enterocolitis. The median age at transfer for surgery was 8 days. Thirteen patients underwent the Norwood procedure, with 31% of mortality, and 47% of survival at one year. Conclusions: Neonatal management of patients with HLHS is complex and the multidisciplinary approach is fundamental. Mortality around the first surgical stage of our cohort is greater than the international reports which could be influenced by the absence of fetal therapy and the higher incidence of extracardiac malformations.
dc.fuente.origenWOS
dc.identifier.doi10.32641/andespediatr.v92i4.2787
dc.identifier.eissn2452-6053
dc.identifier.urihttps://doi.org/10.32641/andespediatr.v92i4.2787
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94569
dc.identifier.wosidWOS:000808824400012
dc.issue.numero4
dc.language.isoen
dc.pagina.final583
dc.pagina.inicio576
dc.revistaAndes pediatrica
dc.rightsacceso restringido
dc.subjectCongenital Heart Defects
dc.subjectHypoplastic Left Heart Syndrome
dc.subjectNorwood Procedure
dc.subjectSurvival Rate
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePrenatal diagnosis and early neonatal management of patients with hypoplastic left heart syndrome: experience of a perinatal center
dc.typeartículo
dc.volumen92
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas