Kinetic study of the reaction of pyridoxal 5 '-phosphate with hydrazino compounds of pharmacological activity

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dc.contributor.authorEchevarria Gorostidi, GR
dc.contributor.authorBasagoitia, A
dc.contributor.authorPizarro, E
dc.contributor.authorGoldsmid, R
dc.contributor.authorBlanco, JGS
dc.contributor.authorBlanco, FG
dc.date.accessioned2024-01-10T13:49:45Z
dc.date.available2024-01-10T13:49:45Z
dc.date.issued1998
dc.description.abstractThe kinetics of the reaction between pyridoxal 5'-phosphate (PLP) with carbidopa, hydralazine, and isoniazid, in aqueous solution at variable pH and constant ionic strength of 0.1M was studied spectrophotometrically. The rate constants of formation and hydrolysis of the resulting Schiff base, and its stability were determined in a wide rang of pH. A comparison is made of the formation rate constants with those of PLP with hydrazine. The reactivity shows the sequence isoniazid > hydrazine > carbidopa > hydralazine in the whole range of pH studied. The Schiff bases studied are more stable than those formed by PLP and hexylamine and as stable as those described for the reactions of PLP with poly(L-lysine) or copolypeptides containing L-lysine.
dc.fechaingreso.objetodigital05-04-2024
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1002/hlca.19980810505
dc.identifier.issn0018-019X
dc.identifier.urihttps://doi.org/10.1002/hlca.19980810505
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79477
dc.identifier.wosidWOS:000073596800004
dc.information.autorucQuímica;Santos JG;S/I;98813
dc.issue.numero5
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final844
dc.pagina.inicio837
dc.publisherWILEY-V C H VERLAG GMBH
dc.revistaHELVETICA CHIMICA ACTA
dc.rightsacceso restringido
dc.subjectWATER-DIOXANE MIXTURES
dc.subjectSCHIFF-BASE FORMATION
dc.subjectNORMAL-HEXYLAMINE
dc.subjectL-LYSINE
dc.subjectTHERMODYNAMIC PARAMETERS
dc.subjectNONAQUEOUS MEDIA
dc.subjectAMINO-ACIDS
dc.subject5'-DEOXYPYRIDOXAL
dc.subjectHYDROLYSIS
dc.subjectSTABILITY
dc.subject.ods12 Responsible Consumption and Production
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa12 Producción y consumo responsable
dc.subject.odspa03 Salud y bienestar
dc.titleKinetic study of the reaction of pyridoxal 5 '-phosphate with hydrazino compounds of pharmacological activity
dc.typeartículo
dc.volumen81
sipa.codpersvinculados98813
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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