Boldine Prevents Renal Alterations in Diabetic Rats

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dc.contributor.authorHernandez-Salinas, Romina
dc.contributor.authorVielma, Alejandra Z.
dc.contributor.authorArismendi, Marlene N.
dc.contributor.authorBoric, Mauricio P.
dc.contributor.authorSaez, Juan C.
dc.contributor.authorVelarde, Victoria
dc.date.accessioned2025-01-24T00:06:11Z
dc.date.available2025-01-24T00:06:11Z
dc.date.issued2013
dc.description.abstractDiabetic nephropathy alters both structure and function of the kidney. These alterations are associated with increased levels of reactive oxygen species, matrix proteins, and proinflammatory molecules. Inflammation decreases gap junctional communication and increases hemichannel activity leading to increased membrane permeability and altering tissue homeostasis. Since current treatments for diabetic nephropathy do not prevent renal damage, we postulated an alternative treatment with boldine, an alkaloid obtained from boldo with antioxidant, anti-inflammatory, and hypoglycemic effects. Streptozotocin-induced diabetic and control rats were treated or not treated with boldine (50 mg/Kg/day) for ten weeks. In addition, mesangial cells were cultured under control conditions or in high glucose concentration plus proinflammatory cytokines, with or without boldine (100 mu mol/L). Boldine treatment in diabetic animals prevented the increase in glycemia, blood pressure, renal thiobarbituric acid reactive substances and the urinary protein/creatinine ratio. Boldine also reduced alterations in matrix proteins and markers of renal damage. In mesangial cells, boldine prevented the increase in oxidative stress, the decrease in gap junctional communication, and the increase in cell permeability due to connexin hemichannel activity induced by high glucose and proinflammatory cytokines but did not block gap junction channels. Thus boldine prevented both renal and cellular alterations and could be useful for preventing tissue damage in diabetic subjects.
dc.fuente.origenWOS
dc.identifier.doi10.1155/2013/593672
dc.identifier.eissn2314-6753
dc.identifier.issn2314-6745
dc.identifier.urihttps://doi.org/10.1155/2013/593672
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/101858
dc.identifier.wosidWOS:000328781600001
dc.language.isoen
dc.revistaJournal of diabetes research
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleBoldine Prevents Renal Alterations in Diabetic Rats
dc.typeartículo
dc.volumen2013
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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