Clinical characteristics of children affected by autism spectrum disorder with and without generalized hypotonia

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dc.contributor.authorLopez-Espejo, Mauricio A.
dc.contributor.authorNunez, Alicia C.
dc.contributor.authorMoscoso, Odalie C.
dc.contributor.authorEscobar, Raul G.
dc.date.accessioned2025-01-20T23:50:58Z
dc.date.available2025-01-20T23:50:58Z
dc.date.issued2021
dc.description.abstractIn this cross-sectional study, we aimed to evaluate the association between generalized hypotonia (GH) and demographic features and clinical characteristics in toddlers (2 to 5 years) with autism spectrum disorder (ASD). Among 93 children, 32 (34.4%) had GH. These patients had a later onset of independent walking (17 vs. 15 months, p < 0.01), a higher proportion of motor stereotypies (65.6 vs. 27.9%, p < 0.01), a lower mean total score in the parental-reported Generic Core Scale of Pediatric Quality of Life Inventory 4.0 (71 vs. 76 points, p 0.03), and a higher mean total score in the Calibrated Severity Score of Autism Diagnostic Observation Schedule version 2 at diagnosis (6 vs. 5 points, p 0.02) compared to the group without GH.
dc.description.abstractConclusion: Hypotonia is associated with other motor abnormalities and could be an early marker for higher autistic symptom severity and lower quality of life in young children with ASD.
dc.description.abstractWhat is Known:
dc.description.abstractMotor function is closely related to autism spectrum disorder (ASD)
dc.description.abstractMuscle hypotonia is present in 15% to 67% of children with ASD
dc.description.abstractWhat is New:
dc.description.abstractMuscle hypotonia is associated with higher autistic symptom severity and lower quality of life in children with ASD
dc.description.abstractChildren with ASD and muscle hypotonia have more commonly motor stereotypies and a later onset of independent walking
dc.fuente.origenWOS
dc.identifier.doi10.1007/s00431-021-04038-7
dc.identifier.eissn1432-1076
dc.identifier.issn0340-6199
dc.identifier.urihttps://doi.org/10.1007/s00431-021-04038-7
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94759
dc.identifier.wosidWOS:000640129200003
dc.issue.numero10
dc.language.isoen
dc.pagina.final3246
dc.pagina.inicio3243
dc.revistaEuropean journal of pediatrics
dc.rightsacceso restringido
dc.subjectAutism spectrum disorder
dc.subjectMuscle hypotonia
dc.subjectQuality of life
dc.subjectNeurodevelopmental disorders
dc.subjectPreschool children
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleClinical characteristics of children affected by autism spectrum disorder with and without generalized hypotonia
dc.typeartículo
dc.volumen180
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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