The Neural Basis of Decision-Making and Reward Processing in Adults with Euthymic Bipolar Disorder or Attention-Deficit/Hyperactivity Disorder (ADHD)

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dc.contributor.authorIbanez, Agustin
dc.contributor.authorCetkovich, Marcelo
dc.contributor.authorPetroni, Agustin
dc.contributor.authorUrquina, Hugo
dc.contributor.authorBaez, Sandra
dc.contributor.authorLuz Gonzalez Gadea, Maria
dc.contributor.authorEsteban Kamienkowski, Juan
dc.contributor.authorTorralva, Teresa
dc.contributor.authorTorrente, Fernando
dc.contributor.authorStrejilevich, Sergio
dc.contributor.authorTeitelbaum, Julia
dc.contributor.authorHurtado, Esteban
dc.contributor.authorGuex, Raphael
dc.contributor.authorMelloni, Margherita
dc.contributor.authorLischinsky, Alicia
dc.contributor.authorSigman, Mariano
dc.contributor.authorManes, Facundo
dc.date.accessioned2024-01-10T12:09:44Z
dc.date.available2024-01-10T12:09:44Z
dc.date.issued2012
dc.description.abstractBackground: Attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) share DSM-IV criteria in adults and cause problems in decision-making. Nevertheless, no previous report has assessed a decision-making task that includes the examination of the neural correlates of reward and gambling in adults with ADHD and those with BD.
dc.description.abstractMethodology/Principal Findings: We used the Iowa gambling task (IGT), a task of rational decision-making under risk (RDMUR) and a rapid-decision gambling task (RDGT) which elicits behavioral measures as well as event-related potentials (ERPs: fERN and P3) in connection to the motivational impact of events. We did not observe between-group differences for decision-making under risk or ambiguity (RDMUR and IGT); however, there were significant differences for the ERP-assessed RDGT. Compared to controls, the ADHD group showed a pattern of impaired learning by feedback (fERN) and insensitivity to reward magnitude (P3). This ERP pattern (fERN and P3) was associated with impulsivity, hyperactivity, executive function and working memory. Compared to controls, the BD group showed fERN- and P3-enhanced responses to reward magnitude regardless of valence. This ERP pattern (fERN and P3) was associated with mood and inhibitory control. Consistent with the ERP findings, an analysis of source location revealed reduced responses of the cingulate cortex to the valence and magnitude of rewards in patients with ADHD and BD.
dc.description.abstractConclusions/Significance: Our data suggest that neurophysiological (ERPs) paradigms such as the RDGT are well suited to assess subclinical decision-making processes in patients with ADHD and BD as well as for linking the cingulate cortex with action monitoring systems.
dc.description.funderConsejo Nacional de Investigaciones Cientificas y Tecnicas
dc.description.funderFoundation Instituto de Neurologia Cognitiva and Human Frontiers Program
dc.format.extent11 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1371/journal.pone.0037306
dc.identifier.issn1932-6203
dc.identifier.pubmedidMEDLINE:22624011
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0037306
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76518
dc.identifier.wosidWOS:000305343500094
dc.information.autorucPsicología;Hurtado E;S/I;16876
dc.issue.numero5
dc.language.isoen
dc.nota.accesoSin adjunto
dc.publisherPUBLIC LIBRARY SCIENCE
dc.revistaPLOS ONE
dc.rightsregistro bibliográfico
dc.subjectDEFICIT HYPERACTIVITY DISORDER
dc.subjectMEDIAL FRONTAL-CORTEX
dc.subjectSUSTAINED ATTENTION
dc.subjectCINGULATE CORTEX
dc.subjectVALIDITY
dc.subjectBRAIN
dc.subjectNEUROECONOMICS
dc.subjectIMPULSIVITY
dc.subjectPERFORMANCE
dc.subjectIMPAIRMENT
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe Neural Basis of Decision-Making and Reward Processing in Adults with Euthymic Bipolar Disorder or Attention-Deficit/Hyperactivity Disorder (ADHD)
dc.typeartículo
dc.volumen7
sipa.codpersvinculados16876
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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