Association between demographic, clinical characteristics and severe complications by SARS-CoV-2 infection in a community-based healthcare network in Chile

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dc.catalogadordfo
dc.contributor.authorLeniz Martelli, Javiera
dc.contributor.authorHernández Jaña, Sam Steven
dc.contributor.authorSoto Durán, Mauricio Javier
dc.contributor.authorSoto, Mauricio
dc.contributor.authorArenas, Eduardo
dc.contributor.authorMargozzini Maira, Paula Andrea
dc.contributor.authorSuárez, Francisco
dc.contributor.authorCapurro, Daniel
dc.contributor.authorRojas Villar, María Paulina
dc.contributor.authorBambs Sandoval, Claudia Elena
dc.date.accessioned2025-03-18T12:06:14Z
dc.date.available2025-03-18T12:06:14Z
dc.date.issued2024
dc.description.abstractBackground Most of the evidence on risk factors for COVID-19 complications comes from North America or Europe with very little research from Latin-America. We aimed to evaluate the association between sociodemographic, clinical factors and the risk of COVID-19 complications among adults in Chile, the fifth Latin-American country with more COVID-19 reported cases since de beginning of the Pandemic. Methods A retrospective population-based cohort study using data from electronic health records from a large Primary Care Network, linked to national hospital, immunization, Covid-19 PCR surveillance, mortality and birth records. We included people 18+ years old enrolled in the Primary Care Network between 1st January 2020 and 31st December 2021. Using Multivariate Cox proportional hazard models, we evaluate the association between sociodemographic, clinical characteristics with three COVID-19 complications: (1) a hospital admission, (2) an ICU admission, and (3) death due to a COVID-19 infection that occurred between the 1st January 2020 and the 31st December 2021. Results 44,674 people were included. The mean age was 44.30 (sd 17.31), 55.6% were female, 15.9% had a type of healthcare insurance for people from the lowest category of income, 11.6% and 9.4% had a record of hypertension or diabetes mellitus diagnosis. Among the 44,674 people, 455 (1.02%) had a hospital admission due to a COVID-19 infection and 216(0.48%) of them also had an ICU admission. Among the 44,674 people,148(0.33%) died due to COVID-19 infection. Older age and male sex were consistently associated with a higher risk of the three COVID-19 complications. Hypertension and diabetes were associated with a higher risk of a hospital admission and death, but not with an ICU admissions due to COVID-19 infection. Having two or more COVID-19 vaccine doses compared with no doses was associated with a lower risk of any hospital admission (HR 0.81; 95% CI 0.77–0.84), an ICU admission (HR 0.60; 95% CI 0.57–0.63) and death (HR 0.50; 95% CI 0.46–0.54). Pregnant or puerperal women were more likely to be admitted to hospital (HR 2.89; 95% CI 1.41–5.89) or ICU (HR 3.04; 95% CI 1.01–9.14). Conclusions Sociodemographic and clinical factors associated with COVID-19 complications such as age, sex and pre-existing conditions were comparable to those reported in similar studies from higher-income countries, and can be used to predict severity in COVID-19 patients.
dc.fechaingreso.objetodigital2025-03-18
dc.format.extent18 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1371/journal.pone.0314376
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0314376
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/102705
dc.information.autorucEscuela de Medicina; Leniz Martelli Javiera; 0000-0002-9315-4871; 16027
dc.information.autorucEscuela de Medicina; Hernandez Jaña Sam Steven; S/I; 1183083
dc.information.autorucEscuela de Medicina; Soto Duran Mauricio Javier; 0000-0002-6502-4287; 85108
dc.information.autorucEscuela de Medicina; Margozzini Maira Paula Andrea; 0000-0002-3919-0070; 63265
dc.information.autorucEscuela de Medicina; Rojas Villar Maria Paulina; S/I; 84632
dc.information.autorucEscuela de Medicina; Bambs Sandoval Claudia Elena; 0000-0002-7043-6833; 89631
dc.language.isoen
dc.nota.accesoContenido completo
dc.revistaPLOS One
dc.rightsacceso abierto
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAssociation between demographic, clinical characteristics and severe complications by SARS-CoV-2 infection in a community-based healthcare network in Chile
dc.typeartículo
sipa.codpersvinculados16027
sipa.codpersvinculados1183083
sipa.codpersvinculados85108
sipa.codpersvinculados63265
sipa.codpersvinculados84632
sipa.codpersvinculados89631
sipa.trazabilidadORCID;2025-03-03
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