The Metabolic Syndrome Is Associated With a Higher Resistance to Intravenous Thrombolysis for Acute Ischemic Stroke in Women Than in Men

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dc.contributor.authorArenillas, Juan F.
dc.contributor.authorSandoval, Patricio
dc.contributor.authorPerez de la Ossa, Natalia
dc.contributor.authorMillan, Monica
dc.contributor.authorGuerrero, Cristina
dc.contributor.authorEscudero, Domingo
dc.contributor.authorDorado, Laura
dc.contributor.authorLopez Cancio, Elena
dc.contributor.authorCastillo, Jose
dc.contributor.authorDavalos, Antoni
dc.date.accessioned2024-01-10T12:43:55Z
dc.date.available2024-01-10T12:43:55Z
dc.date.issued2009
dc.description.abstractBackground and Purpose-The metabolic syndrome (MetS) might confer a higher resistance to intravenous thrombolysis in acute middle cerebral artery (MCA) ischemic stroke. MetS increases the risk of stroke in women to a greater extent than in men. We aimed to investigate whether there might be sex differences in the impact of MetS on the response to intravenous thrombolysis for acute MCA ischemic stroke.
dc.description.abstractMethods-We prospectively studied consecutive ischemic stroke patients, treated with intravenous tissue-type plasminogen activator according to SITS-MOST criteria, with an MCA occlusion on prebolus transcranial Doppler examination. Resistance to thrombolysis was defined as the absence of complete MCA recanalization 24 hours after tissue-type plasminogen activator infusion by transcranial Doppler criteria. MetS was diagnosed according to the criteria established by the American Heart Association/National Heart, Lung, and Blood Institute 2005 statement.
dc.description.abstractResults-A total of 125 patients (75 men, 50 women; mean age, 67.6 +/- 11 years) were included. MetS was diagnosed in 76 (61%) patients. Resistance to clot lysis at 24 hours was observed in 53 (42%) patients. Two multivariate-adjusted, logistic-regression models identified that MetS was associated with a higher resistance to tissue-type plasminogen activator, independently of other significant baseline variables (odds ratio=9.8; 95% CI, 3.5 to 27.8; P=0.0001) and of the individual components of the MetS. The MetS was associated with a significantly higher odds of resistance to thrombolysis in women (odds ratio=17.5; 95% CI, 1.9 to 163.1) than in men (odds ratio=5.1; 95% CI, 1.6 to 15.6; P for interaction=0.0004).
dc.description.abstractConclusions-The effect of MetS on the resistance to intravenous thrombolysis for acute MCA ischemic stroke appears to be more pronounced in women than in men. (Stroke. 2009; 40: 344-349.)
dc.description.funderSpanish research network
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1161/STROKEAHA.108.531079
dc.identifier.eissn1524-4628
dc.identifier.issn0039-2499
dc.identifier.pubmedidMEDLINE:19109538
dc.identifier.urihttps://doi.org/10.1161/STROKEAHA.108.531079
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77633
dc.identifier.wosidWOS:000262784900002
dc.information.autorucMedicina;Sandoval P;S/I;102093
dc.issue.numero2
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final349
dc.pagina.inicio344
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.revistaSTROKE
dc.rightsregistro bibliográfico
dc.subjectacute stroke
dc.subjectthrombolysis
dc.subjectoutcome
dc.subjectmetabolic syndrome
dc.subjectsex differences
dc.subjectTISSUE-PLASMINOGEN ACTIVATOR
dc.subjectSEX-DIFFERENCES
dc.subjectCARDIOVASCULAR-DISEASE
dc.subjectRISK
dc.subjectATHEROSCLEROSIS
dc.subjectFIBRINOLYSIS
dc.subjectCOAGULATION
dc.subjectMANAGEMENT
dc.subjectMORTALITY
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe Metabolic Syndrome Is Associated With a Higher Resistance to Intravenous Thrombolysis for Acute Ischemic Stroke in Women Than in Men
dc.typeartículo
dc.volumen40
sipa.codpersvinculados102093
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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