Adherence to low tidal volume in the transition to spontaneous ventilation in patients with acute respiratory failure in intensive care units in Latin America (SPIRAL): a study protocol

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dc.article.numbere20240044en
dc.catalogadorvzp
dc.contributor.authorDiniz-Silva, Fabia
dc.contributor.authorPinheiro, Bruno Valle
dc.contributor.authorReyes, Luis Felipe
dc.contributor.authorCavalcanti, Alexandre Biasi
dc.contributor.authorFigueredo, Belinda
dc.contributor.authorRios, Fernando
dc.contributor.authorMachado, Flávia Ribeiro
dc.contributor.authorPreda, Gabriel
dc.contributor.authorBugedo Tarraza, Guillermo Jaime
dc.contributor.authorMaia, Israel Silva
dc.contributor.authorda Silveira, Leda Tomiko Yamada
dc.contributor.authorHerrera, Luis
dc.contributor.authorJibaja, Manuel
dc.contributor.authorIbarra-Estrada, Miguel
dc.contributor.authorCestari, Mino
dc.contributor.authorNin, Nicolás
dc.contributor.authorRoldan, Rollin
dc.contributor.authorDos Santos, Tiago Mendonça
dc.contributor.authorVeiga, Viviane Cordeiro
dc.contributor.authorBruhn Cruz, Alejandro Rodrigo
dc.contributor.authorFerreira, Juliana Carvalho
dc.date.accessioned2025-03-11T13:04:46Z
dc.date.available2025-03-11T13:04:46Z
dc.date.issued2024
dc.description.abstract© 2024, Associacao de Medicina Intensiva Brasileira - AMIB. All rights reserved.Objective: Patients with acute respiratory failure often require mechanical ventilation to reduce the work of breathing and improve gas exchange; however, this may exacerbate lung injury. Protective ventilation strategies, characterized by low tidal volumes (≤ 8mL/kg of predicted body weight) and limited plateau pressure below 30cmH2O, have shown improved outcomes in patients with acute respiratory distress syndrome. However, in the transition to spontaneous ventilation, it can be challenging to maintain tidal volume within protective levels, and it is unclear whether low tidal volumes during spontaneous ventilation impact patient outcomes. We developed a study protocol to estimate the prevalence of low tidal volume ventilation in the first 24 hours of spontaneous ventilation in patients with hypoxemic acute respiratory failure and its association with ventilator-free days and survival. Methods: We designed a multicenter, multinational, cohort study with a 28-day follow-up that will include patients with acute respiratory failure, defined as a partial oxygen pressure/ fraction of inspired oxygen ratio < 300mmHg, in transition to spontaneous ventilation in intensive care units in Latin America. Results: We plan to include 422 patients in ten countries. The primary outcomes are the prevalence of low tidal volume in the first 24 hours of spontaneous ventilation and ventilator-free days on day 28. The secondary outcomes are intensive care unit and hospital mortality, incidence of asynchrony and return to controlled ventilation and sedation. Conclusion: In this study, we will assess the prevalence of low tidal volume during spontaneous ventilation and its association with clinical outcomes, which can inform clinical practice and future clinical trials.
dc.description.funderCAPES
dc.description.funderConselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.funderCNPq
dc.fechaingreso.objetodigital2025-03-11
dc.format.extent9 páginas
dc.fuente.origenSCOPUS
dc.identifier.doi10.62675/2965-2774.20240044-en
dc.identifier.issn2965-2774
dc.identifier.scopusidSCOPUS_ID:85200548172
dc.identifier.urihttps://doi.org/10.62675/2965-2774.20240044-en
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/102480
dc.information.autorucEscuela de Medicina; Bugedo Tarraza, Guillermo Jaime; 0000-0001-7527-6202; 60490
dc.information.autorucEscuela de Medicina; Bruhn Cruz, Alejandro Rodrigo; 0000-0001-8034-1937; 741
dc.language.isoen
dc.nota.accesocontenido completo
dc.publisherAssociacao de Medicina Intensiva Brasileira - AMIB
dc.revistaCritical Care Science
dc.rightsacceso abierto
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHospital mortality
dc.subjectIncidence
dc.subjectIntensive care units
dc.subjectOxygen
dc.subjectPrevalence
dc.subjectRespiration, artificial
dc.subjectRespiratory insufficiency
dc.subjectTidal volume
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAdherence to low tidal volume in the transition to spontaneous ventilation in patients with acute respiratory failure in intensive care units in Latin America (SPIRAL): a study protocol
dc.typeartículo
dc.volumen36
sipa.codpersvinculados60490
sipa.codpersvinculados741
sipa.trazabilidadSCOPUS;2024-08-25
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