Sleep-dependent decorrelation of hippocampal spatial representations

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dc.article.number110076
dc.contributor.authorValdivia, Gonzalo
dc.contributor.authorEspinosa, Nelson
dc.contributor.authorLara-Vasquez, Ariel
dc.contributor.authorCaneo, Mauricio
dc.contributor.authorInostroza, Marion
dc.contributor.authorBorn, Jan
dc.contributor.authorFuentealba, Pablo
dc.date.accessioned2024-08-01T08:00:09Z
dc.date.available2024-08-01T08:00:09Z
dc.date.issued2024
dc.description.abstract© 2024 The Author(s)Neuronal ensembles are crucial for episodic memory and spatial mapping. Sleep, particularly non-REM (NREM), is vital for memory consolidation, as it triggers plasticity mechanisms through brain oscillations that reactivate neuronal ensembles. Here, we assessed their role in consolidating hippocampal spatial representations during sleep. We recorded hippocampus activity in rats performing a spatial object-place recognition (OPR) memory task, during encoding and retrieval periods, separated by intervening sleep. Successful OPR retrieval correlated with NREM duration, during which cortical oscillations decreased in power and density as well as neuronal spiking, suggesting global downregulation of network excitability. However, neurons encoding specific spatial locations (i.e., place cells) or objects during OPR showed stronger synchrony with brain oscillations compared to non-encoding neurons, and the stability of spatial representations decreased proportionally with NREM duration. Our findings suggest that NREM sleep may promote flexible remapping in hippocampal ensembles, potentially aiding memory consolidation and adaptation to novel spatial contexts.
dc.description.abstractHighlights: Spatial memory retrieval linearly correlates with non-REM sleep duration. Cortical oscillations and hippocampal unit spiking decrease during non-REM sleep. Place cells synchronize more with sleep oscillations than non-encoding cells. Stability of hippocampal spatial representations decreases during non-REM sleep.
dc.description.funderANID fondecyt
dc.description.funderANID
dc.fechaingreso.objetodigital2024-08-29
dc.format.extent14 páginas
dc.fuente.origenScopus
dc.identifier.doi10.1016/j.isci.2024.110076
dc.identifier.eissn2330-6696
dc.identifier.issn25890042
dc.identifier.scopusidSCOPUS_ID:85194494230
dc.identifier.urihttps://doi.org/10.1016/j.isci.2024.110076
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87236
dc.identifier.wosidWOS:001239847200001
dc.information.autorucEscuela de Medicina; Lara-Vasquez, Ariel; S/I; 127231
dc.information.autorucEscuela de Medicina; Caneo, Mauricio; S/I; 1092187
dc.information.autorucEscuela de Medicina; Fuentealba, Pablo; 0000-0002-9679-4612; 19184
dc.issue.numero3
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final516
dc.pagina.inicio489
dc.revistaiScience
dc.rightsacceso abierto
dc.subjectBehavioral neuroscience
dc.subjectBiological sciences
dc.subjectCognitive neuroscience
dc.subjectNeuroscience
dc.subjectSystems neuroscience
dc.subject.ddc370
dc.subject.deweyEducaciónes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSleep-dependent decorrelation of hippocampal spatial representations
dc.typeartículo
dc.volumen27
sipa.codpersvinculados127231
sipa.codpersvinculados1092187
sipa.codpersvinculados19184
sipa.indexScopus
sipa.trazabilidadCarga WOS-SCOPUS;01-08-2024
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